Psychiatric aspects of brain tumors: A review

Madhusoodanan, Subramoniam; Ting, Mark Bryan; Farah, Tara; Ugur, Umran

doi:10.5498/wjp.v5.i3.273

Cited by 134 publications

(119 citation statements)

References 92 publications

Supporting

Mentioning

105

Contrasting

Unclassified

Order By: Relevance

“…Most importantly, both benign neoplasms and meningiomas are known to grow at a slower rate than malignant neoplasms, such as glioblastoma, of the brain, 16,17 making them less likely to present initially with focal neurologic deficits or signs of elevated intracranial pressure than a faster-growing tumor such as glioblastoma. 18 As has been noted in several case reports, 11,13,19 particularly for tumors located in the relatively noneloquent frontal lobes, a slow-growing intracranial tumor may not produce any symptoms other than a change in personality until it reaches considerable size. Unfortunately, the OSHPD dataset does not include data that are sufficiently granular to address the issue of precise tumor location.…”

Section: Discussionmentioning

confidence: 85%

“…Alternatively, the second context suggests a reversed relationship in which psychiatric disease may simply represent the earliest manifestation of an underlying brain tumor, 9–11 particularly given that psychiatric symptoms have been shown to correlate with specific tumor locations within the brain. 9,12 This theory has been applied mainly to slow-growing or diffuse tumors, which have the potential to produce isolated psychiatric symptoms long before becoming overtly symptomatic.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Psychiatric Disease Preceding Intracranial Tumor Diagnosis

Tringale

Wilson

Hirshman

et al. 2016

Prim. Care Companion CNS Disord.

View full text Add to dashboard Cite

Objective Here, we examine rates of intracranial tumor diagnoses in patients with and without comorbid psychiatric diagnoses to better understand how psychiatric disease may alter risk profiles for brain tumor diagnosis. Methods We used a longitudinal version of the California Office of Statewide Health Planning and Development (OSHPD) database, which includes all inpatient admissions in California from 1995 to 2010. We examined patients with confirmed hospital admissions from 1997 to 2004. Patients with an intracranial tumor or psychiatric diagnosis on their first hospital admission were excluded. The primary outcome of interest was the diagnosis of intracranial tumor on any subsequent hospitalization within 5 years. Risk of tumor diagnosis was determined via Cox proportional hazard models adjusted for age, gender, race/ethnicity, and comorbidity burden. Subset analyses were performed for various tumor types. Results The risk for diagnosis of an intracranial tumor within 5 years, as determined by the hazard ratio, was 1.61 (95% CI, 1.28–2.04) for bipolar, 1.59 (95% CI, 1.41–1.72) for anxious, and 1.34 (95% CI, 1.25–1.43) for depressed cohorts relative to controls. More specifically, the risk for diagnosis of a primary benign neoplasm was elevated in depressed patients, while the risk for diagnosis of a meningioma was elevated in depressed, anxious, and bipolar disorder patients. Conclusions Patients admitted with certain psychiatric diagnoses appear more likely to be readmitted within 5 years with specific types of intracranial tumor diagnoses. The association between certain psychiatric diagnoses and subsequent brain tumor diagnosis most likely reflects the long-held belief that slow-growing tumors may first present as psychiatric symptoms before being diagnosed. Primary care physicians should consider the possibility of an underlying intracranial tumor in patients with new psychiatric diagnoses.

show abstract

Section: Discussionmentioning

confidence: 85%

mentioning

confidence: 99%

Psychiatric Disease Preceding Intracranial Tumor Diagnosis

Tringale

Wilson

Hirshman

et al. 2016

Prim. Care Companion CNS Disord.

View full text Add to dashboard Cite

show abstract

“…Complex auditory or visual hallucinations are relatively specific for temporal lobe tumors . Overall, structural brain lesions are rare causes of acquired mania, but mania has been associated with right‐sided lesions, especially right‐sided temporal lobe masses . Interestingly, for vascular lesions, both left‐ and right‐sided strokes have been associated with mania.…”

Section: Discussionmentioning

confidence: 99%

“…Other causes include CNS infections, trauma, tumors, and other structural brain 3 Overall, structural brain lesions are rare causes of acquired mania, but mania has been associated with right-sided lesions, especially right-sided temporal lobe masses. 4 Interestingly, for vascular lesions, both left-and right-sided strokes have been associated with mania. One emerging theory is that mania can arise from either excitatory left-sided lesions with hyperactivity of reward-processing areas, or from deactivating right-sided lesions with hypoactivity of emotion-modulating limbic regions.…”

Section: Discussionmentioning

confidence: 99%

Acquired mania associated with a left temporal meningioma

et al. 2018

View full text Add to dashboard Cite

“…Metastatic tumors often present with more neuropsychiatric symptoms 4 . Most brain tumors present with specific neurologic signs due to mass effect, and 78% of patients with brain tumors had psychiatric symptoms, but only 18% presented only with these symptoms as the first clinical manifestation of a brain tumor 5 .…”

Section: Dear Editormentioning

confidence: 99%

Melanoma brain metastases presenting as delirium: a case report

Morais

Cabral

Santos

et al. 2017

Arch. Clin. Psychiatry (São Paulo)

View full text Add to dashboard Cite

Background: Metastatic tumours sometimes present with neuropsychiatric symptoms, however psychiatric symptoms as rarely the first clinical manifestation. Cutaneous melanoma is the third most common cause of brain metastasis, with known risk factors increasing the chance of such central nervous system metastization. Objectives: We present a clinical report of delirium as the first clinical manifestation of melanoma brain metastases, illustrating the relevance of an adequate and early differential diagnosis. Methods: In addition to describing the clinical case, searches were undertaken in PubMed and other databases using keywords such as "brain metastasis", "melanoma", "agitation", "psychiatric" and "delirium". Results: We here report the case of a 52-year-old female patient evaluated by Liaison Psychiatry after sudden onset of delirium while admitted at the Gastroenterology Department to study a hypothesis of pancreatitis. A head CT scan identified brain metastases, and after further examination, including brain biopsy, melanoma brain metastization was confirmed. Discussion: Some of the diagnostic challenges of psychiatric symptoms associated with secondary brain tumours are discussed, underlining the importance of an adequate differential diagnosis when working in Psychiatry Liaison.

show abstract

Psychiatric aspects of brain tumors: A review

Cited by 134 publications

References 92 publications

Psychiatric Disease Preceding Intracranial Tumor Diagnosis

Psychiatric Disease Preceding Intracranial Tumor Diagnosis

Acquired mania associated with a left temporal meningioma

Melanoma brain metastases presenting as delirium: a case report

Contact Info

Product

Resources

About