Psychiatric aspects in Parkinsonism treated with L-dopa

Damásio, António R.; Lobo-Antunes, João; Macedo, Carlos Eduardo

doi:10.1136/jnnp.34.5.502

Cited by 71 publications

(42 citation statements)

References 20 publications

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“…VH were thus initially considered to be a druginduced phenomenon,and were classified as "dopaminomimetic psychosis" or "levodopa psychosis" [3,4,[6][7][8][9][10][11], despite earlier reports showing that VH may occur as a consequence of anticholinergic treatments [12].…”

Section: Introductionmentioning

confidence: 99%

Visual Hallucinations in PD and Lewy Body Dementias: Old and New Hypotheses

Onofrj

Taylor

Monaco

et al. 2013

Behavioural Neurology

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Abstract. Visual Hallucinations (VH) are a common non-motor symptom of Parkinson's Disease (PD) and the Lewy body dementias (LBD) of Parkinson's disease with dementia (PDD) and Dementia with Lewy Bodies (DLB). The origin of VH in PD and LBD is debated: earlier studies considered a number of different possible mechanisms underlying VH including visual disorders, Rapid Eye Movement (REM) Sleep Intrusions, dysfunctions of top down or bottom up visual pathways, and neurotransmitter imbalance. More recently newer hypotheses introduce, among the possible mechanisms of VH, the role of attention networks (ventral and dorsal) and of the Default Mode Network (DMN) a network that is inhibited during attentional tasks and becomes active during rest and self referential imagery. Persistent DMN activity during active tasks with dysfunctional imbalance of dorsal and ventral attentional networks represents a new hypothesis on the mechanism of VH. We review the different methods used to classify VH and discuss reports supporting or challenging the different hypothetical mechanisms of VH.

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Section: Introductionmentioning

confidence: 99%

Visual Hallucinations in PD and Lewy Body Dementias: Old and New Hypotheses

Onofrj

Taylor

Monaco

et al. 2013

Behavioural Neurology

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“…9,10 Early experiences with high doses of L-dopa without peripheral dopa decarboxylase inhibition in PD and bipolar depressive disorder highlighted the frequent occurrence of neuropsychiatric disturbance, including hypomania, psychosis, insomnia, aggression, impulsive behavioral disturbances, and intermittent "mood spells" in which patients would develop sudden feelings of intense exhilaration. 11,12 More recently, it has become apparent that dopaminergic medications may also potentiate the appearance of drug-responsive compulsive behaviors [2][3][4] (pathological gambling, hypersexuality, and food bingeing 3 ) and the development of punding, a form of complex behavioral stereotypy. 13 These drug-responsive behaviors frequently complicate DDS and may be implicated in a common neurobiological process.…”

mentioning

confidence: 99%

“…The aim of this study was to evaluate L-dopa-induced dopamine neurotransmission in the VS of patients with DDS compared with PD control patients using molecular imaging with positron emission tomography (PET) and the dopamine D2/3 receptor ligand 11 C-raclopride (RAC). We also aimed to examine whether the differences in L-dopa-induced endogenous dopamine release in DDS patients mediate the hedonic (ie, pleasurable, euphoric) effects of L-dopa (drug "liking", or a subcomponent of reward termed incentive salience (drug "wanting").…”

mentioning

confidence: 99%

Compulsive drug use linked to sensitized ventral striatal dopamine transmission

Evans

Pavese

Lawrence

et al. 2006

Annals of Neurology

431

270

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“…These disturbances range from agitation, restlessness, and depression to suicidal attempts (113)(114)(115)(116)(117)(118)(119)(120)(121)(122)(123). On the other hand, Barbeau (114) and Yahret aL (113) observed alleviation of depression during T-dopa therapy.…”

Section: L-dopamentioning

confidence: 99%

Drug-Induced Mood Disorders

Ananth¹,

Ghadirian²

1980

Int Pharmacopsychiatry

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Various drugs including antihypertensives, anxiolytics, antibiotics, antidepressants, corticosteroids, choline, indomethacin, levodopa, metronidazole, neuroleptics, oral contraceptives, sulphonamides and physostigmine have been reported to produce depression as a side effect. Clinically, these drug-induced depressions may go unnoticed and thus create therapeutic problems. Although causal relationship is difficult to establish, depression occurring during the course of drug treatment needs an evaluation of all the medications that the patient has been receiving. We believe that postpsychotic depressions include three types of depression: pendular depression — primarily disease related; chronic depression - primarily environment related, and amine-depletion depression - drug related. Thus, drug-induced depressions constitute a subgroup of postpsychotic depression. Clinically, it is essential to carefully monitor patients receiving drugs known to produce depression. Thus, prompt recognition of the drug-induced depressions may assist in initiating proper therapeutic measures.

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Psychiatric aspects in Parkinsonism treated with L-dopa

Cited by 71 publications

References 20 publications

Visual Hallucinations in PD and Lewy Body Dementias: Old and New Hypotheses

Visual Hallucinations in PD and Lewy Body Dementias: Old and New Hypotheses

Compulsive drug use linked to sensitized ventral striatal dopamine transmission

Drug-Induced Mood Disorders

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