Psychiatric and Medical Comorbidity in the Primary Care Geriatric Patient—An Update

Kennedy, Gary J.; Castro, Jack; Chang, Mason; Chauhan-James, Jaimini; Fishman, Manuel

doi:10.1007/s11920-016-0700-7

Cited by 15 publications

(14 citation statements)

References 86 publications

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“…The CES-D appeared to have no additional effect, when we also adjusted for comorbidities. This might reflect the high proportion of participants with low scores and a potential inter-relation between comorbidities with depression 48 and also knee pain.…”

Section: Discussionmentioning

confidence: 99%

Association of knee pain with a reduction in thigh muscle strength – a cross-sectional analysis including 4553 osteoarthritis initiative participants

Ruhdorfer

Wirth

Eckstein

2017

Osteoarthritis and Cartilage

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Objective To cross-sectionally determine the quantitative relationship of age-adjusted, sex-specific isometric knee extensor and flexor strength to patient-reported knee pain. Methods Difference of thigh muscle strength by age, and that of age-adjusted strength per unit increase on the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) knee pain scale, was estimated from linear regression analysis of 4553 Osteoarthritis Initiative participants (58% women). Strata encompassing the minimal clinically important difference (MCID) in knee pain were compared to evaluate a potentially non-linear relationship between WOMAC pain levels and muscle strength. Results In Osteoarthritis Initiative participants without pain, the age-related difference in isometric knee extensor strength was −9.0%/−8.2% (women/men) per decade, and that of flexor strength was −11%/−6.9%. Differences in age-adjusted strength values for each unit of WOMAC pain (1/20) amounted to −1.9%/−1.6% for extensor and −2.5%/−1.7% for flexor strength. Differences in torque/weight for each unit of WOMAC pain ranged from −3.3 to − 2.1%. There was no indication of a non-linear relationship between pain and strength across the range of observed WOMAC values, and similar results were observed in women and men. Conclusion Each increase by 1/20 units in WOMAC pain was associated with a ~2% lower age-adjusted isometric extensor and flexor strength in either sex. As a reduction in muscle strength is known to prospectively increase symptoms in knee osteoarthritis and as pain appears to reduce thigh muscle strength, adequate therapy of pain and muscle strength is required in knee osteoarthritis patients to avoid a vicious circle of self-sustaining clinical deterioration.

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Section: Discussionmentioning

confidence: 99%

Association of knee pain with a reduction in thigh muscle strength – a cross-sectional analysis including 4553 osteoarthritis initiative participants

Ruhdorfer

Wirth

Eckstein

2017

Osteoarthritis and Cartilage

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“…to keep in mind that the situation with respect to elderly individuals is far more complex. In this context, multifactorial problems including polypharmacy [ 78 ] , multimorbidity [ 79 ] (e. g. combination of venous/arterial disease and metabolic disorders), as well as impaired physical and mental abilities [ 80 ] have to be addressed.…”

Section: Challenges and Perspectives In The Treatment Of Chronic Wounmentioning

confidence: 99%

“…Planung einer Behandlungsstrategie keinesfalls vergessen werden, dass die Situation bei älteren Menschen weitaus komplexer ist. In diesem Zusammenhang müssen multifaktorielle Probleme wie Polypharmazie [ 78 ] , Multimorbidität [ 79 ] (wie eine Kombination aus einer venösen/arteriellen und einer Stoffwechselerkrankung) sowie die Beeinträchtigung körperlicher und geistiger Fähigkeiten [ 80 ] in Angriff berücksichtigt werden.…”

Section: Mögliche Biomarker Bei Wundheilungsstörungenunclassified

Pathogenesis of wound healing disorders in the elderly

Makrantonaki

Wlaschek

Scharffetter‐Kochanek

2017

J Deutsche Derma Gesell

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Summary The elderly constitute the age group most susceptible to wound healing disorders and chronic wounds, the most prevalent being venous leg ulcers, pressure ulcers, and diabetic foot ulcers. However, other age‐associated diseases should also be taken into consideration in the diagnostic workup of chronic wounds, and not be underestimated. A better understanding of the pathomechanisms involved in the wound healing process is of key importance in combatting the difficulties associated with the treatment of chronic wounds. In recent decades, considerable progress has been made in the development of pioneering therapeutic strategies for chronic wounds. In this context, the use of growth factors and cytokines, tissue engineering, and cell therapy – including stem cells – have proven very promising. Nevertheless, prior to their introduction into routine clinical practice, large controlled clinical trials are required to assess the safety of these techniques.

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“…Darüber hinaus darf bei der Planung einer Behandlungsstrategie keinesfalls vergessen werden, dass die Situation bei älteren Menschen weitaus komplexer ist. In diesem Zusammenhang müssen multifaktorielle Probleme wie Polypharmazie , Multimorbidität (wie eine Kombination aus einer venösen/arteriellen und einer Stoffwechselerkrankung) sowie die Beeinträchtigung körperlicher und geistiger Fähigkeiten in Angriff berücksichtigt werden.…”

Section: Herausforderungen Und Perspektiven Der Behandlung Chronischeunclassified

Pathogenese von Wundheilungsstörungen bei älteren Patienten

Makrantonaki

Wlaschek

Scharffetter‐Kochanek

2017

J Deutsche Derma Gesell

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Zusammenfassung Ältere Menschen sind für Wundheilungsstörungen und chronische Wunden am anfälligsten, insbesondere für venöse Beinulzera, Dekubitalulzera und diabetische Fußulzera. Jedoch sollten bei der diagnostischen Abklärung chronischer Wunden weitere altersassoziierte Krankheiten in Betracht gezogen werden. Ein besseres Verständnis der an Wundheilungsstörungen beteiligten Pathomechanismen ist wichtig für die Bewältigung der Schwierigkeiten bei der Behandlung chronischer Wunden. In den letzten Jahrzehnten wurden beachtliche Fortschritte bei zukunftsweisenden Therapien chronischer Wunden erzielt. In diesem Zusammenhang haben sich Wachstumsfaktoren und Zytokine, Gewebeanzucht (Tissue Engineering) und Zelltherapie – auch mit Stammzellen – als sehr vielversprechend erwiesen. Vor Einführung in die klinische Praxis muss jedoch die Sicherheit dieser Techniken durch umfangreiche klinische Studien nachgewiesen werden.

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Psychiatric and Medical Comorbidity in the Primary Care Geriatric Patient—An Update

Cited by 15 publications

References 86 publications

Association of knee pain with a reduction in thigh muscle strength – a cross-sectional analysis including 4553 osteoarthritis initiative participants

Association of knee pain with a reduction in thigh muscle strength – a cross-sectional analysis including 4553 osteoarthritis initiative participants

Pathogenesis of wound healing disorders in the elderly

Pathogenese von Wundheilungsstörungen bei älteren Patienten

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