Psychiatric and cognitive correlates of quality of life among persons with primary brain tumors

Abstract

Background:Quality of life (QoL) in primary brain tumour (PBT) is often the main outcome measure in an otherwise incurable disease. The impact of psychiatric, cognitive correlates on quality of life in primary brain tumours is less well studied.Aims and objectives:The primary objective was to find out the association of psychiatric morbidity, cognitive functions with quality of life in patients with primary brain tumours. The secondary objective was to study whether any association exists with tumour grading, laterality, location and psychiatric morbidity.Materials and Methods:100 consecutive patients of PBT were screened in the Neuro-behavioural Clinic. Age, gender matched 52 healthy subjects were taken for comparison. Quality of life (qol) measure (EORTC), Hospital Anxiety Depression Scale (HADS), GHQ (12 item) and Mini Mental State Examination (MMSE) were administered.Results:52 PBT cases were included, out of which 17.30% had Organic Anxiety Disorder (F06.4), 23.07% had Organic Mood disorder (F06.3%).Statistically significant association was found in EORTC qol scores and anxiety scores (p 0.001), depressive scores (p 0.029), psychiatric morbidity (p0.000) .Significant association with tumour laterality, depression scores (p0.041) was found. PBT patients had poor quality of life as compared to matched healthy volunteers (p <0.001). Significant negative correlation between EORTC B-20, cognitive scores using Spearman's Rho (p0.005; r - 0.385), implying more symptoms with poor cognitive function scores. Psychiatric morbidity, cognitive dysfunction, poor qol were noted, though no association with tumour grading, location.Conclusion:Regular assessments, early intervention will help in improving quality of life in PBT.

Translation and validation of the Urdu version of the European organization for research and treatment of cancer core quality of life questionnaire (EORTC QLQ-C30) and brain module (QLQ-BN20) in primary brain tumor patients

“…Previous studies have also reported similar positive correlations between QoL and resilience [ 34 , 35 ] and similar negative correlations between QoL and depression and anxiety in cancer patients [ 36 , 37 ]. In addition, the Hindi translation of the EORTC QLQ-BN20 has also demonstrated significant correlations with depression and anxiety as measured by HADS [ 38 ].…”

Distinguishing and treating depression, anxiety, adjustment, and post-traumatic stress disorders in brain tumor patients

“…In some cases, treatment can be a greater risk factor for impairment than tumor location, and adverse cognitive effects following chemotherapy and radiotherapy for brain tumors have been particularly well-described (137,(139)(140)(141). Mental deficits can lead to emotional dysfunction, and cognitive impairment is associated with both anxiety and depression in patients with brain tumors (142)(143)(144)(145). In addition, many patients with brain tumors experience sleep dysfunction, which can also contribute to the development of depression (10).…”

Majör depresif bozukluk belirtileri ile başvuran olfaktör oluk menenjiyomu: Bir olgu sunumu

“…It has been reported that depression is more common in frontal lobe tumors. More specifically, left frontal lobe tumors were more associated with depression [3,7].…”

“…The localization of tumor, its edema and mass effect cause the dysfunction of neuronal foci and therefore psychiatric symptoms occur [3]. While a tumor in the dorsolateral prefrontal region may lead to deficiencies in executive function, a tumor in the orbitofrontal region may lead to disinhibition, medial-frontal region tumor may lead apathy and amotivation and temporal limbic tumors may lead to psychosis [4].…”

“…It has been reported that depression is more common in frontal lobe tumors. More specifically, left frontal lobe tumors were more associated with depression [3,7]. Meningioma is the most common primary central nervous system tumor responsible for almost 37% of all cases [10].…”