Psychedelics: Old drugs, new trips

Rucker, James; Seth, Pallab

doi:10.1177/02698811211003495

Cited by 1 publication

(1 citation statement)

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“…However, scientific research remained sporadic until the synthesis of lysergic acid diethylamide (LSD) by Dr. Hofmann in 1938 2 , 3 which marked the beginning of the pre-prohibition era of psychedelic research. During this prolific period of clinical experimentation and scientific inquiry, clinicians and researchers studied the use of LSD and other classical psychedelics in the treatment of a range psychiatric disorders 4 . However, increased recreational use, concerns about safety and abuse, and shifting political attitudes led to the prohibition of psychedelics by the late 1960s and early 1970s.…”

Section: Introductionmentioning

confidence: 99%

A rapid narrative review of the clinical evolution of psychedelic treatment in clinical trials

Kishon,

Modlin,

Cycowicz

et al. 2024

npj Mental Health Res

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Pre-prohibition psychedelic research with complex psychiatric patients generated a wealth of treatment methodologies and practices, providing invaluable clinical insights pertaining to the medical administration of psychedelics in various mental health diagnoses. Building upon these early studies, which lack the rigor and research tools available today, contemporary psychedelic research has focused on investigating the safety and efficacy of psychedelics in randomized controlled trials via psychometric measures and symptom assessments. Both then and now, the treatment context and the role of clinicians in psychedelic treatment has been recognized as an essential feature for positive patient outcomes. To broaden the knowledge base of modern psychedelic research and support the training of clinicians conducting medically supervised psychedelic research studies, this paper provides a review of pre-prohibition clinical research narratives pertaining to the phenomenology of psychedelic treatment and the role of the non-pharmacological treatment factors in the patient experience. Lastly, this paper explores a range of clinician perspectives and psychological interventions employed in pre-prohibition psychedelic research to inform future research directions and best practice guidelines.

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Section: Introductionmentioning

confidence: 99%