PSY2 Coexistence of Immuno-Mediated Inflammatory Diseases: an Analysis of the Quebec Administrative Health Databases

Abstract

in pre-pubertal children with idiopathic GH Deficiency (GHD) and Turner Syndrome (TS). The long-term prediction of height was validated in new cohorts of pre-pubertal children with GHD (nϭ 664) or TS (nϭ607) from KIGS. RESULTS: When height was simulated from GH start in GHD, the predicted mean (SD) gain after 4 years was 30.4 (3.4) cm; the observed height gain was 30.0 (5.0) cm. In TS the corresponding predicted and observed mean gains were 27.2 (2.2) and 26.5 (3.8) cm. CONCLUSIONS: Sequential application of annual KIGS growth prediction models permits accurate simulation of height development during the first four years of GH treatment in GHD and TS and is applicable for patient groups from GH start. Long-term growth simulation helps managing patient's expectations and facilitates an individualised, cost effective growth hormone (GH) therapy in children.