PSY2 Adverse Event Burden, Resource Use and Costs Associated With Immunosuppressant Therapy for the Treatment of Systemic Lupus Erythematosus: A Systematic Literature Review

Abstract

ing task with five trials and an interference list (15 new words -List B) read to the subject after the fifth trial of List A. The original RAVLT also includes a recognition trial in which subjects are asked to identify List A words from a larger list of words that includes distractor words. In most versions of the RAVLT, the distractor list is comprised of words from List B as well as other words, most having either a semantic and/or a phonetic link with words from Lists A and/or B. The objective of this abstract is to present the translation process of the RAVLT into US Spanish (six pairs of recall lists and six recognition lists). METHODS: For the recall words, a direct translation, in collaboration with a speech therapist and a neuropsychologist, was recommended, with frequency of use similar to the original as well as word length (Ϯ1 syllable or Ϯ2 syllables and Ϯ2 characters). For the recognition words, the translations had to respect the semantic and phonetic links to the recall words. RESULTS: Fifty out of 180 words from the recall lists raised discussions because of difficulties in finding translations with the appropriate word length. Thirty-four out of 120 words from the recognition list proved difficult to translate because of problems in finding direct translations that respected the phonetic or semantic links to the recall words. For instance, the recognition word "Balloon," OBJECTIVES: To review the methodology of studies evaluating pregnancy/birth/ child development outcomes of prenatal antidepressant exposure (PAE) and, when appropriate, assess the impact on study results using meta-regression. METHODS: A Medline search was conducted up to October 2011, restricting to English and human literature. The MeSH term "antidepressive agents," was combined with MeSH terms for spontaneous abortion, preterm birth(PB), birth weight, small for gestational age, or poor child development. We added relevant articles from reference lists of reviews and included studies. We proposed that antidepressant class, type of data source, adjustment for maternal depression, exposure definition, duration and timing, and adjustment for more than three covariates would impact study results. Cochran's Q statistic was used to test for heterogeneity of results. When heterogeneity existed, meta-regression using a random-effects model was performed to examine the impact of different methodological choices on study results. Meta-regression is a regression analysis in which each study is a unit of observation and the effect estimate is regressed on study characteristics. RESULTS: Of 33 studies included, we found differences in the definition of PAE, data sources, and covariates adjusted. Thirteen studies focused on selective serotonin reuptake inhibitors. Five studies defined exposure as one prescription of antidepressant during pregnancy versus 13 studies required PAE for at least one trimester. Pregnancy information services, birth registries, and referrals from hospitals/clinics were the most common data sources. Only 10 studies...