Psoriatic arthritis: one year in review 2022

Cigolini, Cosimo; Fattorini, Federico; Gentileschi, Stefano; Terenzi, Riccardo; Carli, Linda

doi:10.55563/clinexprheumatol/x3sfxe

Cited by 11 publications

(10 citation statements)

References 59 publications

(70 reference statements)

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“…Poorer physical health has been linked to delayed PsA diagnosis. The potential of "personalized medicine" could encourage additional advancements in treatment quality in the future [ 21 ]. Clinical features are as follows, increasing the risk of PsA depending on the severity of psoriasis.…”

Section: Reviewmentioning

confidence: 99%

The Current Advancement in Psoriasis

Bhagwat,

Madke

2023

Cureus

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The study on psoriasis disease helps improve the condition and treatment options day by day in dermatology. In the current scenario, research is ongoing to make the best interventions possible for managing the disease. Psoriasis is one of the most common dermatological conditions wherein chronic inflammation of the skin occurs, characterized by the formation of a rash with scaly, itchy patches over the body surface. The condition is mainly related to the immune system wherein epidermal hyperplasia occurs with infiltration of immune cells. Many factors can trigger psoriasis. Environmental, emotional, hereditary, and personal habits are responsible for the conditions. The current research helps to gain a complete understanding, and the basic knowledge of the state with recent advancements in treatment strategies and characteristic features can also be studied. The main aim is to know the disease's primary root cause and management. It involves the main sites of the body. The most commonly affected parts are the scalp, trunks, knees, elbow, and ankle. It is a chronic long-term disease. Sometimes it may be painful. Itching, bleeding, and disturbed sleep patterns are common symptoms. Most commonly involves the upper epidermal surface. The prevalence of the condition has been increased as it is associated with other comorbidities. The main focus of the treatment is to restrict skin cell multiplication and remove scaly surfaces. This review discusses the advancement in the treatment, its initiation, progression, current symptoms, and disease development. The study also includes basic knowledge about the types of psoriatic disease with its specific features and mechanisms.

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Section: Reviewmentioning

confidence: 99%

The Current Advancement in Psoriasis

Bhagwat,

Madke

2023

Cureus

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“…Compared to the general population, FM is particularly common in chronic inflammatory arthropathies, including psoriatic arthritis (PsA) [6], a complex inflammatory musculoskeletal disease with the highest prevalence among 30-60-year-old patients and with no sex differences [7]. PsA may occur in around ~30% of patients with skin psoriasis (PsO) [7], and it is also associated with higher risk of developing comorbidities, including uveitis, inflammatory bowel disease, and metabolic syndrome, with a significant impact on quality of life [8]. Although the precise mechanisms underlying PsA pathogenesis are poorly understood, several immune-inflammatory pathways have been identified, leading to the development of novel therapeutic strategies [9].…”

Section: Introductionmentioning

confidence: 99%

Psoriasis and Fibromyalgia: A Systematic Review

D’Onghia,

Ursini,

Cinotti

et al. 2024

JPM

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Psoriasis is a chronic inflammatory cutaneous condition characterized by several comorbidities, including musculoskeletal disorders. While the association with psoriatic arthritis has been widely addressed in literature, the aim of the present systematic review was to identify all available evidence on the relationship between psoriasis and fibromyalgia, a musculoskeletal syndrome primarily characterized by chronic widespread pain. We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, and MedLine and Web of Science (WOS) databases were searched for literature up to March 2023. After the removal of duplicate records, a total of 11 articles were deemed eligible for inclusion in a qualitative synthesis. Our results suggested that psoriatic patients had a higher prevalence of fibromyalgia (8–30%), with a very high impact on symptoms of psoriasis. Moreover, fibromyalgic patients had a slightly increased prevalence of psoriasis (2.2–6.7%) compared to the control groups. Finally, several studies demonstrated the substantial impact of fibromyalgia on psoriatic outcome measures in patients with concomitant psoriatic arthritis. In conclusion, available data support a potential interplay between psoriasis and fibromyalgia, but further research is encouraged in this area.

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“…Psoriasis is heterogeneous among patients and results in different inflammatory involvement and different clinical features ( 24 ). Variants interact not only with each other through “epistasis” but also with environmental factors, contributing to a multifactorial etiology.…”

Section: Introductionmentioning

confidence: 99%

An observational study on treatment regimens and effectiveness for psoriasis in real-world settings among 407 patients in Southeast China

Huo,

Huang,

Lee

et al. 2024

Front. Med.

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IntroductionWhile new targeted therapies have advanced psoriasis treatment, real-world data on comparative effectiveness is lacking. This study analyzed treatment regimens and response in an observational cohort, examining potential disparities between clinical trials and routine practice.MethodsData from the Psoriasis Standardized Diagnosis and Treatment Center registry were analyzed. Patients with ≥1 follow-up were included. Treatment response was assessed using PASI 50/90 criteria. Factors associated with response were analyzed.Results407 patients were included (46 first-time diagnosed, 361 previously diagnosed). A higher proportion of first-time diagnosed patients achieved treatment response than previously diagnosed (76.1% vs. 62.6%). Multivariable analysis identified factors associated with reduced response in previously treated patients.ConclusionThis real-world study found lower treatment response rates compared to clinical trials, especially in previously treated patients. Disparities highlight remaining unmet needs for psoriasis management. Combination and rotational strategies may improve outcomes in patients unresponsive to available therapies. Ongoing research on novel targets and pathways is warranted to address treatment gaps.

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Psoriatic arthritis: one year in review 2022

Cited by 11 publications

References 59 publications

The Current Advancement in Psoriasis

The Current Advancement in Psoriasis

Psoriasis and Fibromyalgia: A Systematic Review

An observational study on treatment regimens and effectiveness for psoriasis in real-world settings among 407 patients in Southeast China

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