Psoriatic arthritis and nail changes: Exploring the relationship

Sandre, Matthew K; Rohekar, Sherry

doi:10.1016/j.semarthrit.2014.05.002

Cited by 38 publications

(36 citation statements)

References 52 publications

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“…The reported prevalence of nail changes in PsA varied from 32 to 97 % [7] Similarly, the frequency of DIP arthritis was highly variable in different research, from 5.4 to 89 % [2,11,18]. A local analysis reported 89 % of 127 PsA patients had peripheral arthritis; unfortunately, joint area involved was not described [2].…”

Section: Discussionmentioning

confidence: 99%

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Psoriatic nail involvement and its relationship with distal interphalangeal joint disease

et al. 2016

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Psoriatic nail disease and distal interphalangeal (DIP) arthritis both are common manifestations of psoriatic arthritis (PsA). Several clinical characteristics are allegedly associated with DIP joint damage, particularly nail psoriasis. However, there is little evidence to substantiate this phenomenon. The purpose of this study is to investigate the relationship between DIP involvement, nail psoriasis and other parameters. A cross-sectional study involved 45 patients from local rheumatology clinic. Four hundred fifty psoriatic fingernails scored, and the radiographs of all these fingers were reviewed to define PsA DIP arthritic changes. 64.4 % patients had nail psoriasis and 35.6 % had DIP arthritis. Univariate analysis identified that swollen joint-count, digits with chronic dactylitis, HLA-B27 status and nail psoriasis were associated with DIP arthritis. Regression model supported that nail disease was the most significant associated factor of DIP arthritis (OR 9.7, p = 0.05). Nail psoriasis was identified in 40.2 % of digits. Pitting (29.6 %), onycholysis (15.1 %), crumbling (8.2 %), nail bed hyperkeratosis (2.0 %) were noted with the mean modified Nail Psoriasis Severity Index of 0.95 +/-1.68. Among all digits, 57 had DIP arthritis while 393 did not. Within DIP joints with PsA radiological change, 59.6 % had nail disease. Chi-square test with the Bonferroni correction further supported an association between nail psoriasis and DIP involvement with p value of 0.001. Two specific nail subtypes-crumbling and onycholysis-were found to be significantly associated with DIP disease. A significant proportion of PsA patients had nail involvement and DIP arthritis. PsA patients with nail changes may be more susceptible to DIP disease.

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Section: Discussionmentioning

confidence: 99%

“…Several clinical characteristics have been reported to be indicators of DIP joint destruction, with particular emphasis on the frequently encountered psoriatic nail disease [1,2,7,8]. According to the worldwide report, the prevalence of psoriasis nail varied from 30.2 to 97 % [1,2].…”

Section: Introductionmentioning

confidence: 99%

Psoriatic nail involvement and its relationship with distal interphalangeal joint disease

et al. 2016

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“…Если затронута ногтевая матрица, присутствует риск развития питтинга, лейконихии, красных бляшек (эритемы) в ногтевой лунке, онихорексиса и ониходистрофии (рис. 2) [17,18]. Если же поражено ногтевое ложе, то существует риск развития «масляных пятен», точечного кровотечения, онихолиза и подногтевого гиперкератоза.…”

Section: анатомическая взаимосвязь ногтевого аппарата с артритомunclassified

“…Если же поражено ногтевое ложе, то существует риск развития «масляных пятен», точечного кровотечения, онихолиза и подногтевого гиперкератоза. Несмотря на то что многие исследования отличаются в определении самого часто встречаемого типа изменения ногтевой пластины, в каче-стве наиболее распространенных патологий у пациентов с ПА определяют питтинг и онихолиз [18].…”

Section: анатомическая взаимосвязь ногтевого аппарата с артритомunclassified

Enthesitis and Psoriatic Onychopathy as a Factor for Prediction of Psoriatic Arthritis in Psoriasis

Сидорчик

Линев

Радзыня

et al. 2018

Vestnik dermatologii i venerologii

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Psoriatic arthritis is a psoriasis-related spondyloarthropathy that occurs in 20–30 % of patients with psoriasis. Psoriatic arthritis affects the patient’s quality of life indicators and are more often associated with disabilities of working age than psoriasis skin form. Nail psoriasis has been proposed as a predictor for the development of psoriatic arthritis. The inflammation involving the entheses, called enthesitis, is an early inflammatory change seen in psoriatic arthritis, and nail changes appear to result from the close relationship between the nail and the enthesis of the distal interphalangeal extensor tendon, one of the main entheseal compartments affected in psoriatic arthritis. Various imaging studies have demonstrated that there is a considerable proportion of undiagnosed psoriatic arthritis among patients with psoriasis. Since early detection and treatment of psoriatic arthritis could, ultimately, allow the prevention of clinical and radiologic progression of the disease, there is the need to establish clinical indicators to detect this risk.

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“…Recent studies underlined the existence of a link between nail psoriasis and synovio-entheseal complex in psoriatic arthritis [43][44][45]. Therefore the presence of nail changes in patients with distal interphalangeal joint involvement could be a clinical predictor of psoriatic arthritis and patients should be further investigated in order to enhance a precocious diagnosis [46,47].…”

Section: Psoriatic Arthropathymentioning

confidence: 99%

Ultrasonography in psoriatic disease

et al. 2015

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Psoriasis represents a common, chronic inflammatory disease involving the skin, nails and joints. Nail psoriasis in usually investigated and diagnosed by clinical examination. New insights support ultrasonography as being a non-invasive reliable imaging technique for studying nail and skin involvement in patients with psoriasis. Power Doppler frequency, higher than 10MHz enables a very sensitive detection and semiquantitative assessment of the blood flow at the dermal level and in the nail bed. In this review we will present the main US findings in skin and nail psoriasis, and discuss the importance of ultrasonography in diagnosing and monitoring psoriasis vulgaris.

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Psoriatic arthritis and nail changes: Exploring the relationship

Cited by 38 publications

References 52 publications

Psoriatic nail involvement and its relationship with distal interphalangeal joint disease

Psoriatic nail involvement and its relationship with distal interphalangeal joint disease

Enthesitis and Psoriatic Onychopathy as a Factor for Prediction of Psoriatic Arthritis in Psoriasis

Ultrasonography in psoriatic disease

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