Psoriasis vulgaris with fibrokeratoma from pityriasis amiantacea

Shiiya, Chihiro; Nomura, Yukiko; Fujita, Yasuyuki; Nakayama, Chihiro; Shimizu, Hiroshi

doi:10.1016/j.jdcr.2017.04.002

Cited by 4 publications

(7 citation statements)

References 5 publications

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“…[245] Several factors have been implicated in PA development such as drugs, anxiety, and abrupt changes in the environmental conditions. [678] Some descriptive data support a probable participation of tumor necrosis factor-alpha (TNF-α) and interferon-α in the pathogenesis of PA.[67] In patients with Crohn's disease treated with TNF-α inhibitors, a stimulation of alternative pro-inflammatory pathways, including up-regulation of the IL-1 family, potential generation of autoreactive T cells, and keratinocyte proliferation, is observed. [69]…”

Section: Discussionmentioning

confidence: 99%

Development of pityriasis amiantacea after valproic acid therapy

et al. 2018

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Here, we present the case of a 16-year-old male who developed pityriasis amiantacea (PA) after the use of valproic acid. We propose that the keratinocyte proliferative activity of valproic acid mediated through the inhibition of glycogen synthase kinase-3β, and subsequent activation of the Wnt/β-catenin pathway could play a role in the development of PA. We additionally review the most relevant characteristics of this disease.

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Section: Discussionmentioning

confidence: 99%

Development of pityriasis amiantacea after valproic acid therapy

et al. 2018

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“…reported an unusual case of ADFK accompanied by pyogenic granuloma, a common benign vascular growth of the skin that usually presents as a solitary red papule . A case of fibrokeratoma of the scalp arising from pityriasis amiantacea lesions secondary to psoriasis vulgaris was reported in 2017 . Pityriasis amiantacea is a rare condition characterized by masses of waxy and sticky scales that adhere to the scalp and hair bundles and can be associated with psoriasis, tinea capitis, or atopic dermatitis.…”

Section: Associated Syndromes or Diseasesmentioning

confidence: 99%

“…24 A case of fibrokeratoma of the scalp arising from pityriasis amiantacea lesions secondary to psoriasis vulgaris was reported in 2017. 25 Pityriasis amiantacea is a rare condition characterized by masses of waxy and sticky scales that adhere to the scalp and hair bundles and can be associated with psoriasis, tinea capitis, or atopic dermatitis. It was the only reported case of fibrokeratoma arising from the scalp and thought to arise because of trauma from the patient's repetitive picking of the scaly lesions.…”

Section: Associated Syndromes or Diseasesmentioning

confidence: 99%

“…It was the only reported case of fibrokeratoma arising from the scalp and thought to arise because of trauma from the patient's repetitive picking of the scaly lesions. 25 Due to clinical and histologic resemblance, it remains controversial whether Koenen's tumor is considered to be a variant of ADFK. 12,26 Koenen's tumor is also known as periungual fibroma and associated with tuberous sclerosis.…”

Section: Associated Syndromes or Diseasesmentioning

confidence: 99%

“…Pityriasis amiantacea is a rare condition characterized by masses of waxy and sticky scales that adhere to the scalp and hair bundles and can be associated with psoriasis, tinea capitis, or atopic dermatitis. It was the only reported case of fibrokeratoma arising from the scalp and thought to arise because of trauma from the patient's repetitive picking of the scaly lesions . Due to clinical and histologic resemblance, it remains controversial whether Koenen's tumor is considered to be a variant of ADFK .…”

Section: Associated Syndromes or Diseasesmentioning

confidence: 99%

See 2 more Smart Citations

Acquired digital fibrokeratoma: review of its clinical and dermoscopic features and differential diagnosis

Shih

Khachemoune

2018

Int J Dermatology

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Acquired digital fibrokeratoma (ADFK) is a rare, benign, fibrous tumor that most often occurs on fingers. It may resemble a rudimentary supernumerary digit and is often misdiagnosed as another common benign condition, such as common wart. It is typically asymptomatic and occurs as a solitary nodule less than 1 cm in diameter. Oftentimes ADFK shares clinical and/or histologic resemblance with other benign and malignant cutaneous conditions so it is crucial that careful examination is undertaken. In this article, we will discuss the clinical presentation, epidemiology, etiology, dermoscopic and histologic findings, management, and differential diagnoses for ADFK, with the hope that this review will facilitate timely diagnosis and management for this distinct condition.

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A retrospective study on the clinical features of skin lesions in Chinese acquired digital fibrokeratoma patients

Liu

Zhu

Chen³

et al. 2023

J of Cosmetic Dermatology

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BackgroundAcquired digital fibrokeratoma (ADFK) is an uncommon benign fibro‐epithelioma, which is rarely reported in China.AimsTo analysis the clinical features of ADFK in Chinese people from current cases.MethodsFrom December 2019 to October 2021, there were 21 patients diagnosed with ADFK, we made a retrospective analysis on the clinical features of skin lesions in them. To summarize the clinical morphology, location, and surgical follow‐up of ADFK.ResultsWe concluded that ADFK is more common in females than males on the hands (7:3), while the male‐to‐female ratio is largely the same in feet (6:5). It occurs more frequently on the third finger (60%) and first toe (45.5%). As to clinical morphology, it is typically rod‐shaped (52.4%), followed by dome‐shaped (42.8%) and wart‐shaped (4.8%). It is typically dome‐shaped on the hands (80%) and rod‐shaped on the feet (81.8%). In terms of location on the fingers (toes), such skin lesions are most common at the proximal nail fold (52.4%), which can also occur at the nail matrix (14.3%), periungual area (23.8%), and subungual area (9.5%). Nevertheless, this ratio also varies on the hands and feet. All patients got surgical excision of the skin lesion, who were followed up for 6–12 months, without recurrence.ConclusionsMost ADFKs are associated with trauma, whose clinical features are related to location and gender. ADFKs on the hands are different from those on the feet regarding clinical morphology and location on fingers (toes), and surgery is effective in treating this condition.

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Psoriasis vulgaris with fibrokeratoma from pityriasis amiantacea

Cited by 4 publications

References 5 publications

Development of pityriasis amiantacea after valproic acid therapy

Development of pityriasis amiantacea after valproic acid therapy

Acquired digital fibrokeratoma: review of its clinical and dermoscopic features and differential diagnosis

A retrospective study on the clinical features of skin lesions in Chinese acquired digital fibrokeratoma patients

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