Psoriasis under haemodialysis

Increased risk of incident psoriasis in end‐stage renal disease patients on chronic hemodialysis: A nationwide population‐based cohort study

“…The risk of psoriatic arthritis did not increase in HD patients, probably because the local effect of repetitive needling of the arteriovenous fistula did not directly affect the joint. This finding is consistent with that of previous case reports, that none of the patients who developed psoriasis after HD or peritoneal dialysis had concomitant arthritis. Fewer patients with psoriasis in the HD cohort received systemic medicines than the control group, possibly owing to the risk of severe adverse effects.…”

“…Acquired perforating dermatosis, calciphylaxis, porphyria cutanea tarda and pseudoporphyria are less common but are specific to chronic renal failure . The development of new‐onset psoriasis in patients with ESRD treated with chronic dialysis has been described in several published case reports, which are summarized in Table . The psoriatic lesions tended to develop on the needling site of the HD fistula or the exit site of the peritoneal dialysis catheter owing to the Koebner phenomenon, and may prevent the amount of effective dialysis or increase the risk of secondary infection that leads to line sepsis or peritonitis .…”

“…Whether the chronic inflammation and immune dysregulation in patients with ESRD on chronic HD affect the development of chronic inflammatory disease such as psoriasis is unknown. In the published work review regarding the development of new‐onset psoriasis after chronic dialysis, several case reports have indicated that patients may develop psoriasis 1–6 years after starting HD or peritoneal dialysis . Some patients developed psoriatic lesions on the needling site of the HD fistula, site of central venous access or at the exit site of the peritoneal dialysis catheter, showing a manifestation of Koebner phenomenon (the recurrence of skin lesions at sites of trauma) .…”

New‐onset psoriasis in a maintenance hemodialysis patient

“…New-onset psoriasis is extremely rare in hemodialysis (HD) patients, and there are only a few case reports in the literature coming mainly from the seventies. [1][2][3][4][5][6] Both HD and peritoneal dialysis (PD) have been used to treat extensive psoriasis even in patients without renal failure, 7 in tandem with cyclosporin A (CyA), which has been established as an effective antipsoriatic agent. 8 We report a patient who despite undergoing effective HD, developed severe psoriasis, which was treated successfully with CyA.…”

Local injection of latency‐associated peptide, a linker propeptide specific for active form of transforming growth factor‐beta1, inhibits dermal sclerosis in bleomycin‐induced murine scleroderma

“…Systemic sclerosis (SSc) is an autoimmune-based, multisystem connective tissue disorder of unknown aetiology, characterized by fibrosis and microvascular injury in the affected organs (1). The disease affects all organ systems, particularly skin, blood vessels, lungs, kidneys, gastrointestinal tract and heart, thus resulting in high morbidity and mortality.…”