Psoriasis treatment: faster and long‐standing results after bathing in geothermal seawater. A randomized trial of three <scp>UVB</scp> phototherapy regimens

Eysteinsdóttir, Jenna Huld; Ólafsson, Jón; Agnarsson, Bjarni A.; Lúðvíksson, Björn Rúnar; Sigurgeirsson, Bárður

doi:10.1111/phpp.12090

Cited by 22 publications

(16 citation statements)

References 20 publications

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“…This study is a retrospective large case series that took place from January 2011 to April 2011 at the following dermatology outpatient units in Iceland: The dermatology outpatient center at Landspitali-The National University Hospital of Iceland, Reykjavik; Hudlaeknastodin dermatology clinic, Kopavogur; and the Blue Lagoon geothermal clinic, Grindavik (21). A total of 374 psoriasis patients were approached when visiting these clinics and offered to participate, and 275 (127 males and 148 females) agreed to participate in the study (73.5 percent response rate).…”

Section: Methodsmentioning

confidence: 99%

Throat Infections are Associated with Exacerbation in a Substantial Proportion of Patients with Chronic Plaque Psoriasis

et al. 2014

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Streptococcal throat infections are known to trigger or exacerbate psoriasis, and several studies support the benefit of tonsillectomy. To evaluate the potential of tonsillectomy as a treatment, we used a retrospective study-specific questionnaire to assess the proportion of psoriasis patients with sore throat-associated psoriasis exacerbations. Our survey sampled 275 psoriasis patients. 42% of patients with plaque psoriasis reported sore throat-associated psoriasis exacerbations, and 72% of patients with confirmed streptococcal infections reported aggravation. Notably, women and early onset psoriasis patients were more likely to report psoriasis exacerbation after a sore throat (p<0.001, p=0.046 respectively). Other psoriasis aggravation factors were more common in patients with sore throat-associated exacerbations (p<0.01). 49% of tonsillectomized patients reported subsequent improvement and had more frequent sore throat-associated aggravation of psoriasis than patients who did not improve after tonsillectomy (p=0.015). These findings suggest a closer association between sore throats, streptococcal throat infections and plaque psoriasis than previously reported.

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Section: Methodsmentioning

confidence: 99%

Throat Infections are Associated with Exacerbation in a Substantial Proportion of Patients with Chronic Plaque Psoriasis

et al. 2014

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“…at the Blue Lagoon, Iceland and also the Dead Sea and other Mediterranean areas, where patients with chronic skin diseases such as psoriasis are exposed to solar UVR. [25][26][27] However, treatment with UVR from UV lamps is preferable; different UVR sources are used for different treatments and guidelines regarding the clinical use of phototherapy have been developed. 28 Broadband UV-B is mainly used for radiation between 280 and 350 nm (Philips TL12) or from about 290 to 370 nm (Waldman UV6) ( Fig.…”

Section: Treatment With Solar Uv and Uv Lampsmentioning

confidence: 99%

UVR: sun, lamps, pigmentation and vitamin D

Lerche

Philipsen

Wulf

2017

Photochem Photobiol Sci

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Exposure to ultraviolet radiation (UVR) has important and significant consequences on human health. Recently, there has been renewed interest in the beneficial effects of UVR. This perspective gives an introduction to the solar spectrum, UV lamps, UV dosimetry, skin pigment and vitamin D. The health benefits of UVR exposure through vitamin D production or non-vitamin D pathways will be discussed in this themed issue in the following articles.

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“…Eysteinsdóttir et al assessed histopathological changes before and after UVB‐NB treatment using Trozak's score and found no difference in the total score of 16 patients with psoriasis vulgaris after 6 weeks of treatment …”

Section: Discussionmentioning

confidence: 99%

“…6,7 The effects of phototherapy are based on local immunosuppression activity, reduction of epidermal hyperproliferation, and lymphocyte apoptosis T. 8 Several studies show remission of histopathological changes after use of phototherapy [9][10][11][12][13] and others go further, discussing the importance of grading these changes through quantitative histopathological systems. 3,14,15 Although several researchers have assessed the histopathological effects of this therapy modality, none used a morphological classification system specific to psoriasis. 3,14,15 Hence, the objective of this study was to evaluate the clinical and histopathological responses to treatment with PUVA and UVB-NB in patients with moderate to severe plaque psoriasis, with use of PASI and TROZAK.…”

Section: Introductionmentioning

confidence: 99%

“…3,14,15 Although several researchers have assessed the histopathological effects of this therapy modality, none used a morphological classification system specific to psoriasis. 3,14,15 Hence, the objective of this study was to evaluate the clinical and histopathological responses to treatment with PUVA and UVB-NB in patients with moderate to severe plaque psoriasis, with use of PASI and TROZAK. Psoriasis severity was evaluated clinically by the same researcher, using PASI at the beginning and at the end of phototherapy.…”

Section: Introductionmentioning

confidence: 99%

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Quantification of histopathological changes in patients with psoriasis before and after phototherapy

Noronha‐Neta

Picciani

Niemeyer‐Corbellini

et al. 2019

Photoderm Photoimm Photomed

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Background One of the most used resources for the treatment of psoriasis is ultraviolet radiation (UV) with psoralens (PUVA) and narrow‐band UV (UVB‐NB 311‐312 nm). Although many researchers have assessed the histopathological effects of this therapy modality, none used a morphological classification system specific to psoriasis. Purpose To assess the clinical and histopathological response in the phototherapy treatment of plaque psoriasis with PUVA and UVB‐NB with use of PASI and TROZAK. Methods Histopathological changes of plaque psoriasis were quantified with help of the grading system for psoriasis—Trozak in 20 patients of both sexes, before and after 32 PUVA phototherapy sessions (10 patients—GPUVA) and UVB‐NB (10 patients—GUVB‐NB). The severity and extension of psoriasis was evaluated through PASI. The slides stained with hematoxylin and eosin were scanned in an Aperio CS2 scanner (Leica Biosystems) and evaluated through the software ImageScopeTM (Aperio Technologies). Statistical analysis was performed with the use of the program SPSS 22.0, with application of the Wilcoxon and Mann‐Whitney tests. Results All patients presented improvement in psoriatic plaques with decrease in PASI after treatment (P < 0.01) and significant reduction in histopathological changes in psoriasis from 15.4 ± 1.7 to 3.7 ± 3.2 (P < 0.01) in group GPUVA and from 13.2 ± 1.7 to 4.9 ± 5.2 (P < 0,01) in group GUVB‐NB. Conclusions Phototherapy, regardless of type, is an effective treatment for moderate and severe psoriasis, with possibility of being quantified clinically by PASI and histopathologically by Trozak.

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Psoriasis treatment: faster and long‐standing results after bathing in geothermal seawater. A randomized trial of three UVB phototherapy regimens

Abstract: SUMMARY BackgroundThe combination of seawater baths and narrowband ultraviolet B (NB-UVB) is a known treatment for psoriasis. This study evaluates two treatment regimens that combine bathing in geothermal seawater and NB-UVB therapy in comparison with NB-UVB monotherapy.

Cited by 22 publications

References 20 publications

Throat Infections are Associated with Exacerbation in a Substantial Proportion of Patients with Chronic Plaque Psoriasis

Throat Infections are Associated with Exacerbation in a Substantial Proportion of Patients with Chronic Plaque Psoriasis

UVR: sun, lamps, pigmentation and vitamin D

Quantification of histopathological changes in patients with psoriasis before and after phototherapy

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