Psoriasis Severity is Affected by T the Lipid Profile in Egyptian Patients

Amer, Mohamed; Galal, Ahmed

doi:10.4172/2161-0932.1000346

Cited by 4 publications

(4 citation statements)

References 7 publications

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“…Studies done in recent years have shown a significant increase in TC, TAG, LDL, very low-density lipoprotein, and decrease in HDL in psoriasis patients as compared to non-psoriatic controls. 23 – 26 The HDL-cholesterol was significantly decreased in our study, which is in agreement with previous studies, whereas Javidi et al, in his study, reported no difference in HDL level between psoriasis patients and controls. 27 We did not find significant changes in the rest of the lipid profile like TC, TAG, and LDL, which is quite opposite to the findings of previous research.…”

Section: Discussionsupporting

confidence: 93%

Evaluation of ADA activity as a potential marker of disease severity in psoriasis patients

Khan

Agrawal

Baral

et al. 2018

PTT

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BackgroundPsoriasis is a dermatological disorder with a multifactorial origin and is associated with many biochemical and immunological changes.PurposeThis study aimed to examine the association of serum ADA activity, uric acid (UA), and high-sensitivity CRP (hs-CRP) with psoriasis and the role of ADA in disease severity.Materials and methodsIn this comparative cross-sectional study, 50 clinically and histopathologically diagnosed psoriasis patients and 50 age- and sex-matched healthy controls were enrolled. Blood samples were taken and analysis of the biochemical parameters was performed according to Giuisti and Galanti method, uricase and ELISA technique for ADA activity, UA, and hs-CRP, respectively. The severity of the disease was scored according to Psoriasis Area and Severity Index (PASI). Statistical analysis of differences within and between the study groups was carried out using the Student’s t-test, one-way post hoc ANOVA, and Pearson’s correlation. Linear regression was used to establish the independent association of ADA with disease severity.ResultsThe serum ADA activity, UA, and hs-CRP levels of the psoriatic patients were found to be significantly higher (P<0.001). hs-CRP was positively correlated with ADA and UA in patients (P<0.001). There was no significant difference in total cholesterol, low-density lipoprotein, and triacylglycerol in psoriasis patients, whereas we noted a decreased high-density lipoprotein level in psoriasis patients as compared to controls. Linear regression showed that ADA was independently associated with the disease severity and was statistically significant (P<0.001).ConclusionADA activity was positively and significantly associated with the severity of psoriasis, therefore, it could be suggested as a marker for disease severity in psoriasis patients.

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Section: Discussionsupporting

confidence: 93%

Evaluation of ADA activity as a potential marker of disease severity in psoriasis patients

Khan

Agrawal

Baral

et al. 2018

PTT

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“…This is in agreement with many earlier reports [6,8,9]. Further the elevations in plasma lipid parameters observed in present study in psoriasis patients as well as in clinically sub grouped psoriasis patients is in agreement with studies of Mohammed Amer et al, [33].…”

Section: Resultssupporting

confidence: 94%

Plasma Lipid Profile Parameters and Their Internal Ratios in Clinically Sub - Grouped Psoriasis Patients

Srinivas¹,

Rt²

2018

IJCDR

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Though there are reports available to show the abnormal plasma lipid levels in psoriasis patients but the reports regarding to show the relationship of plasma lipid parameters with the severity of the disease as well as the internal reciprocals of these lipid parameters with the severity of the disease in clinically sub grouped psoriasis patients are few. Hence a study was planned to assess the plasma lipid profile parameters and their internal ratios in clinically sub grouped psoriasis patients with an emphasis on the clinical utility of these lipid parameters and their ratio in assessing the

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“…These findings do not match with previous studies conducted on psoriasis patients. They reported the higher total cholesterol, LDL and triglyceride levels and lower HDL levels in psoriasis patients compared with that of control group [11][12][13][14][15] . Elevated serum total cholesterol and triglyceride levels were also demonstrated in patients with pemphigus compared with controls.…”

Section: Discussionmentioning

confidence: 97%

Ringworm: Evaluation of C-reactive Protein and Lipid Profile as well as Their Correlation with the Patients Age and Body Mass Index

Hossen¹,

Kar²,

Haque³

2020

Bangladesh J Med Sci

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Objectives: Ringworm is a common cutaneous fungal disease with worldwide distribution.It may lead to the abnormal c-reactive protein levels and metabolism of lipid. Thus this study has been designed for determining serum CRP and also evaluating the Lipid profile in patients associated with ringworm. Materials and methods: This study recruited 25 patients with ringworm (cases) and 25 healthy individuals (controls). A questionnaire of personal characteristics was completed for each patient and control. Inflammatory marker (CRP) and Serum lipid profile (total, lowdensity lipoprotein (LDL), high-density lipoprotein (HDL) cholesterol and triglyceride) was recorded for each case and control. The test of significance was applied for statistical analysis. Results and discussion: The mean serum CRP were 1.608±0.14 and 0.648±0.03 mg/dl and total cholesterol level were 175.09±3.26 and 182.09±3.01 mg/dl in ringworm patients and control subject respectively. It was also observed that the serum TG; HDL; LDL levels were 131.76±3.07 and 139.84±3.47 mg/dl; 80.79±1.79 and 73.35±4.14 mg/dl; 67.95±4.64 and 86.55±3.70 mg/dl in patients and control group respectively. The value of CRP was significantly increased in patients compared to control group (p <0.05). There was no significant difference of lipid profile study between patients and control Conclusion: Findings of this study indicate increased concentrations of CRP in patients affected to ringworm and its role in this infection. Patients should thus be routinely screened for such abnormalities Probably observation of lipid profile in healthy individuals in compare with patients group indicates that it has no relationship in case of ringworm. Bangladesh Journal of Medical Science Vol.19(4) 2020 p.673-677

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Psoriasis Severity is Affected by T the Lipid Profile in Egyptian Patients

Abstract: According to world psoriasis day consortium about 125 million people all over the world suffer from this disease, however, in some countries there is a higher prevalence rate of psoriasis, as in Kazakhstan,

Cited by 4 publications

References 7 publications

Evaluation of ADA activity as a potential marker of disease severity in psoriasis patients

Evaluation of ADA activity as a potential marker of disease severity in psoriasis patients

Plasma Lipid Profile Parameters and Their Internal Ratios in Clinically Sub - Grouped Psoriasis Patients

Ringworm: Evaluation of C-reactive Protein and Lipid Profile as well as Their Correlation with the Patients Age and Body Mass Index

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