Psoriasis, polymorphonuclear leukocytes, and lithium carbonate. An important clue

Lazarus, G. S.

doi:10.1001/archderm.115.10.1183

Cited by 15 publications

(6 citation statements)

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“…8 On the other hand, psoriasis is a common skin disease with general erythema associated with scales, and histollgical findings of hyperkeratosis and Munro's microabscess. With regard to psoriasis, many trigger factors have been suggested, such as heredity, 9 mental stress, 10 drugs ( -blockes, 11 angiotensin-converting enzyme inhibitors, 12 antimalarials, 13 and lithum 14 ), and infection. 15,16 However, the precise cause remains unclear.…”

Section: Discussionmentioning

confidence: 99%

Nonalcoholic steatohepatitis associated with psoriasis vulgaris

et al. 2004

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A 24-year-old man was admitted to our hospital because of liver dysfunction. He had been diagnosed as having psoriasis vulgaris at 18 years of age. Physical examination demonstrated obesity, general erythema, and hepatomegaly. Laboratory data revealed elevated serum levels of aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, and glucose. A histological examination of the liver revealed macrovesicular fatty change and infiltration of inflammatory cells, including lymphocytes and polymorphonuclear cells, within the liver lobules. Pericentral fibrosis and pericellular fibrosis were also recognized. He was diagnosed as having nonalcoholic steatohepatitis (NASH), based on the fact that he had no habit of drinking alcohol, as well as psoriasis vulgaris and diabetes mellitus. We herein report a very rare case of NASH associated with psoriasis vulgaris.

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Section: Discussionmentioning

confidence: 99%

Nonalcoholic steatohepatitis associated with psoriasis vulgaris

et al. 2004

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“…These triggers also worsen psoriasis and can induce a severe relapse. Medications reported to initiate or exacerbate psoriasis include β‐blockers, 10 angiotensin‐converting enzyme inhibitors, 11 antimalarials 12 and lithium 13 …”

Section: External Triggersmentioning

confidence: 99%

Psoriasis: immunopathogenesis and evolving immunomodulators and systemic therapies; U.S. experiences

2004

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Given the role of the inflammatory immune responses in the pathogenesis of psoriasis, the goal of modern medicine and pharmacotherapy lies in the design and use of specific targets in cell-mediated immune reactions and the modulation of the expression of various inflammatory cytokines. The clinical evidence of efficacy of some of these new biological immunomodulatory agents from several U.S.-based research studies and clinical experiences is convincing.

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“…Psychological stress can be a precipitating factor and may be mediated via neuroimmunological mechanisms. 11 Several drugs such as beta-blockers, 12 angiotensin-converting enzyme inhibitors, 13 antimalarials, 14 and lithium 15 have been reported to trigger or exacerbate psoriasis.…”

Section: Trigger Factorsmentioning

confidence: 99%

Recent developments in the understanding of the pathogenesis of psoriasis

1999

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Recent studies have provided new insights into the molecular mechanisms involved in the pathogenesis of psoriasis. Patients may inherit a predisposition to psoriasis, although the disease is expressed only after being triggered by certain environmental or antigenic factors. There is considerable genetic heterogeneity in psoriasis and several genetic loci associated with the occurrence of the disease have been identified. Although the underlying abnormality in psoriasis has not been definitively identified, recent evidence suggests that activated T lymphocytes play an important role in the pathogenesis of the disease. The activation of T lymphocytes can be mediated through antigen-presenting cells or through autoimmunity, and is influenced by cytokines. Recently developed animal models and in vitro studies of psoriasis have provided new evidence for the role of pathogenic lymphocytes in the initiation of the disease process. Further research will help to identify the susceptibility genes involved in psoriasis and provide a more complete understanding of the immunological basis of the disease. This should lead to the development of targeted therapies with improved efficacy and tolerability compared with some currently available treatments.

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Psoriasis, polymorphonuclear leukocytes, and lithium carbonate. An important clue

Cited by 15 publications

References 0 publications

Nonalcoholic steatohepatitis associated with psoriasis vulgaris

Nonalcoholic steatohepatitis associated with psoriasis vulgaris

Psoriasis: immunopathogenesis and evolving immunomodulators and systemic therapies; U.S. experiences

Recent developments in the understanding of the pathogenesis of psoriasis

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