Psoriasis: pathological mechanisms, current pharmacological therapies, and emerging drug delivery systems

Rapalli, Vamshi Krishna; Waghule, Tejashree; Gorantla, Srividya; Dubey, Sunil Kumar; Saha, Ranendra Narayan; Singhvi, Gautam

doi:10.1016/j.drudis.2020.09.023

Cited by 55 publications

(36 citation statements)

References 81 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It affects about 2–3% of the world’s population, with a prevalence of young adults (15–25 years old); moreover, 10–30% of the affected people can also develop psoriasis arthritis at later stages. The rapid reoccurrence and the peculiar appearance may have sociological implications on patients’ everyday lives, thereby causing significant morbidity [ 191 ]. Although governed by the patient’s immune system, the intricate pathophysiology of psoriasis has been attributed to several factors, such as genetic predisposition and environmental triggers (e.g., trauma, emotional stress, infections).…”

Section: Hydroxycinnamic Acids and Derivatives: Activities On Skin Disordersmentioning

confidence: 99%

“…In the past decades, various pathogenic mechanisms have been identified, leading to different therapeutic approaches with improved patient compliance and limited adverse effects. Usually, treatments for psoriasis management comprise topical therapy (with vitamin D analogues, corticosteroids, retinoids in the form of gels, creams, and ointments), systemic therapy (with orally delivered immunosuppressants such as methotrexate and cyclosporine), phototherapy, and biological agents (such as monoclonal antibodies, gene therapy, anti-cytokine treatments, anti-T cells therapy, phosphodiesterase 4 inhibitors) [ 191 ].…”

Section: Hydroxycinnamic Acids and Derivatives: Activities On Skin Disordersmentioning

confidence: 99%

“…Recently, various plant-based therapeutics have been effectively employed for the psoriasis treatment, such as extracts from Aloe vera , Curcuma longa , Mahonia aquifolium , Matricaria recutita , Silybum marianum , Gaultheria procumbens , and Thespesia populnea , which acted reducing TNF-a, IL-8, IL-12, and p65 expression levels [ 191 ].…”

Section: Hydroxycinnamic Acids and Derivatives: Activities On Skin Disordersmentioning

confidence: 99%

“…Therefore, multiple and frequent applications are needed to obtain a therapeutic effect, thus causing possible skin irritation. To overcome these limitations and improve the patient response, advanced nano-formulations (such as solid lipid nanoparticles, nanostructured lipid particles, polymeric nanoparticles, and nano-emulsions) have been explored as psoriasis drug delivery systems [ 191 , 192 ]. Nanocarriers with optimized size, shape, surface charge, and functionalities (hyaluronic acid, heparin sulfate, or chondroitin sulfate with affinity towards skin receptors) have shown an enhanced permeation through the stratum corneum by loosening the tight junctions between the epithelial cells and delivering their bioactive molecules into the skin deeper layers.…”

Section: Hydroxycinnamic Acids and Derivatives: Activities On Skin Disordersmentioning

confidence: 99%

See 3 more Smart Citations

Hydroxycinnamic Acids and Derivatives Formulations for Skin Damages and Disorders: A Review

et al. 2021

View full text Add to dashboard Cite

Alterations of skin homeostasis are widely diffused in our everyday life both due to accidental injuries, such as wounds and burns, and physiological conditions, such as late-stage diabetes, dermatitis, or psoriasis. These events are locally characterized by an intense inflammatory response, a high generation of harmful free radicals, or an impairment in the immune response regulation, which can profoundly change the skin tissue’ repair process, vulnerability, and functionality. Moreover, diabetes diffusion, antibiotic resistance, and abuse of aggressive soaps and disinfectants following the COVID-19 emergency could be causes for the future spreading of skin disorders. In the last years, hydroxycinnamic acids and derivatives have been investigated and applied in several research fields for their anti-oxidant, anti-inflammatory, and anti-bacterial activities. First, in this study, we give an overview of these natural molecules’ current source and applications. Afterwards, we review their potential role as valid alternatives to the current therapies, supporting the management and rebalancing of skin disorders and diseases at different levels. Also, we will introduce the recent advances in the design of biomaterials loaded with these phenolic compounds, specifically suitable for skin disorders treatments. Lastly, we will suggest future perspectives for introducing hydroxycinnamic acids and derivatives in treating skin disorders.

show abstract

Section: Hydroxycinnamic Acids and Derivatives: Activities On Skin Disordersmentioning

confidence: 99%

Section: Hydroxycinnamic Acids and Derivatives: Activities On Skin Disordersmentioning

confidence: 99%

Section: Hydroxycinnamic Acids and Derivatives: Activities On Skin Disordersmentioning

confidence: 99%

Section: Hydroxycinnamic Acids and Derivatives: Activities On Skin Disordersmentioning

confidence: 99%

See 2 more Smart Citations

Hydroxycinnamic Acids and Derivatives Formulations for Skin Damages and Disorders: A Review

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Epidermal growth describes elongated rete pegs, thickening, and differentiation changes. This pattern of growth is termed as “psoriasiform” hyperplasia (Rapalli et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Potential herbal constituents for psoriasis treatment as protective and effective therapy

Dabholkar

Rapalli

Singhvi

2020

Phytotherapy Research

Self Cite

View full text Add to dashboard Cite

Psoriasis is a multifactorial and chronic skin disorder. It is a recurrent disease that requires incessant therapy. Psoriasis treatment includes topical and systemic routes using synthetic drugs that lead to severe unwanted adverse effects. Herbal therapy is widely used for thousands of years in countries like China and India. The use of herbal therapy in the developed region enhanced to a great extent and showed better efficacy towards psoriasis alone or as adjuvant to synthetic therapy. Herbal medicines have gained great attention in the treatment of psoriasis due to their lesser side effects compared to synthetic drugs. In this review, the various plant sources which have been found effective in psoriasis and can be used to develop novel therapeutics have been discussed. The mechanisms by which the phytoconstituents elicit antipsoriatic activity and various research studies that have proven the effectiveness of these natural products have also been compiled in this review.

show abstract

Yinxieling decoction ameliorates psoriasis by regulating the differentiation and functions of Langerhans cells via the TGF‐β1/PU.1/IL‐23 signal axis

Li,

Ke,

et al. 2024

Cell Biochemistry & Function

View full text Add to dashboard Cite

Langerhans cells (LCs) play a critical role in skin immune responses and the development of psoriasis. Yinxieling (YXL) is a representative Chinese herbal medicine for the treatment of psoriasis in South China. It was found to improve psoriasis without obvious side effects in the clinic. Here we attempted to clarify whether and how YXL regulates the differentiation and functions of LCs in Imiquimod (IMQ)‐induced psoriasis in vivo and induced LCs in vitro. The Psoriasis Area Severity Index (PASI) score was used to evaluate the efficacy of YXL for IMQ‐induced psoriasis‐like mice. Flow cytometry was utilized to analyze the effects of YXL, to regulate the differentiation, migration, maturation, and antigen presentation of LCs. The results show that YXL significantly alleviated skin inflammation, as reduced in PASI score and classic psoriasis characteristics in pathological sections. Although there was no effect on the proportion of total DCs in the skin‐draining lymph nodes, the expression of epidermal LCs and its transcription factor PU.1 were both markedly inhibited. LCs were also prevented from migrating from epidermal to skin‐draining lymph nodes and mature. In addition, the number of LCs carrying antigens in the epidermis increased, which suggested that YXL could effectively prevent LCs from presenting antigens. In vitro, YXL had a significant impact on inhibiting the differentiation of LCs. Further data showed that YXL decreased the relative expression of transforming growth factor‐β (TGFβ) messenger RNA (mRNA) and interleukin‐23 (IL‐23) mRNAs. Thus, YXL alleviates psoriasis by regulating differentiation, migration, maturation, and antigen presentation via the TGFβ/PU.1/IL‐23 signal axis.

show abstract

Psoriasis: pathological mechanisms, current pharmacological therapies, and emerging drug delivery systems

Cited by 55 publications

References 81 publications

Hydroxycinnamic Acids and Derivatives Formulations for Skin Damages and Disorders: A Review

Hydroxycinnamic Acids and Derivatives Formulations for Skin Damages and Disorders: A Review

Potential herbal constituents for psoriasis treatment as protective and effective therapy

Yinxieling decoction ameliorates psoriasis by regulating the differentiation and functions of Langerhans cells via the TGF‐β1/PU.1/IL‐23 signal axis

Contact Info

Product

Resources

About