Psoriasis, its treatment and cancer in a cohort of Finnish patients

Hannuksela-Svahn, A

doi:10.1016/s0926-9959(98)95695-1

Cited by 42 publications

(92 citation statements)

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“…This is particularly relevant in patients with psoriasis, as an association with internal cancer has been found in large cohort studies, 306,307 which includes oral tumours and tumours of the pharynx, lung, liver, pancreas, liver and bladder, and lymphoma. [308][309][310] However, previous studies have not demonstrated a consistent increase in cancer risk in the central nervous system, thyroid gland, respiratory system, pancreas or kidney. 264,281,311 Although there are several case reports of leukaemia developing during PUVA therapy, [312][313][314][315] Stern and Lange and Stern et al reported no increase in lymphoma or leukaemia in a PUVA cohort, in either 1988 or 1997; 263,279 however, more recent analysis has found the incidence of lymphoma to be increased in this group in those exposed to high levels of MTX (RR 4Á39), that is, 36 months of treatment or longer, but not in those exposed to low levels.…”

Section: Psoralen-ultraviolet a Therapy-induced Skin Cancermentioning

confidence: 99%

“…316 A study from Finland showed a 2Á2-fold increase in non-Hodgkin lymphoma in patients hospitalized for psoriasis. 309 Noncancerous chronic cutaneous side-effects of psoralen-ultraviolet A therapy Keratoses are typically localized to nonsun-exposed skin; risk factors for their development include increased age, male sex and high cumulative UVA dose. 288 They are reported to occur in 46% of patients receiving high-dose (> 2000 J cm À2 ) PUVA and show cytological atypia.…”

Section: Psoralen-ultraviolet a Therapy-induced Skin Cancermentioning

confidence: 99%

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British Association of Dermatologists and British Photodermatology Group guidelines for the safe and effective use of psoralen–ultraviolet A therapy 2015

et al. 2016

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Section: Psoralen-ultraviolet a Therapy-induced Skin Cancermentioning

confidence: 99%

Section: Psoralen-ultraviolet a Therapy-induced Skin Cancermentioning

confidence: 99%

British Association of Dermatologists and British Photodermatology Group guidelines for the safe and effective use of psoralen–ultraviolet A therapy 2015

et al. 2016

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“…results from other studies [19,20] documented the negative effects of substances of abuse on the course of psoriasis, as well as the outcome of treatment. cigarette smoking and unhealthy eating habits may pose a risk of other conditions, including cancers that are more common among psoriasis patients than in the general population [21,22]. it is also important that the mean Bmi in psoriasis patients is above the normal range.…”

Section: Key Resultsmentioning

confidence: 99%

Sociodemographic variables, health-related behaviors, and disease characteristics in patients with psoriasis

Pankowski¹,

Janowski²,

Owczarek³

et al. 2018

fmpcr

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Background. Psoriasis is an inflammatory disease characterized by accelerated proliferation and abnormal keratosis of the epidermis cells. it is influenced by environmental and lifestyle factors, including health-related behaviors. Objectives. The aim of this cross-sectional study was to evaluate the frequency of health-related behaviors and their links with disease characteristics and sociodemographic variables in patients with psoriasis. Material and methods. The study involved 211 patients treated for psoriasis from 3 centers in Poland. diagnosis of psoriasis type was done by a dermatologist. A structured questionnaire about sociodemographic variables, course of psoriasis and health-related behaviors was conducted with each subject. Results. most of the subjects spent less than half an hour a day on physical activity (mainly walking and cycling). more than half did not follow the recommended diet. About one third of the patients declared smoking, and the mean Bmi was in the overweight category. it was also found that sociodemographic variables differentiated the group in terms of health behaviors. relationships were found between health-related behaviors such as smoking and some clinical features of psoriasis. Conclusions. The frequency of favorable health-related behaviors among psoriasis patients is unsatisfactory, and some of them may exert a significant impact on the course and treatment effects of psoriasis.

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“…Also, several cohort and case-control studies led to conclusion that PUVA therapy can cause squamous cell skin cancer in a dose-and time-dependent manner (15). For example, in a study of Hannuksela-Svahn et al (16), the number of patients needed to be treated with PUVA to result in one extra case of this type of skin cancer was 3030. Therefore, the Committee on Herbal Medicinal Products (HMPC) of the European Medicines Agency (EMA) issued the document on the risks associated with FCs contained in preparations of angelica, Angelica archangelica L. (Apiaceae), in which maximum daily intake of FCs through herbal medicinal products is given.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of safety profile of the essential oils of eight Heracleum taxa (Apiaceae) related to determined furanocoumarin content

Ušjak¹,

Drobac²,

Niketić³

et al. 2019

Arhiv za farmaciju

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For essential oils of roots, leaves, flowers and fruits of eight Heracleum taxa (H. sphondylium, H. sibiricum, H. montanum, H. ternatum, H. pyrenaicum subsp. pollinianum, H. pyrenaicum subsp. orsinii, H. verticillatum and H. orphanidis), we previously demonstrated antimicrobial, cytotoxic (selective to cancer cells) and/or antioxidant activities. In this work, for these essential oils maximum daily intake related to total furanocoumarins (FCs) content was estimated, according to Committee on Herbal Medicinal Products of European Medicines Agency (EMA/HMPC) recommendations. FCs were quantified using gas chromatography, and their sum equivalent to xanthotoxin (8-methoxypsoralen, 8-MOP) was calculated. It was shown that daily intake, not contributing significantly to overall risk (equivalent to intake of 1.5 mg FCs) for root essential oils was in the range of 1.94-5.23 mL, for fruit oils of 5.23-15.68 mL and for leaf or flower oils of 2.90-15.68 mL. Daily intake, not posing any unacceptable risk (equivalent to intake of 15 μg FCs) for root oils was in the range of 0.02-0.05 mL, for fruit oils of 0.05-0.16 mL and for leaf or flower oils of 0.03-0.16 mL. This work demonstrates the application of current EMA/HMPC recommendations, in order to establish safety profile of herbal preparations containing FCs.

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Psoriasis, its treatment and cancer in a cohort of Finnish patients

Cited by 42 publications

References 0 publications

British Association of Dermatologists and British Photodermatology Group guidelines for the safe and effective use of psoralen–ultraviolet A therapy 2015

British Association of Dermatologists and British Photodermatology Group guidelines for the safe and effective use of psoralen–ultraviolet A therapy 2015

Sociodemographic variables, health-related behaviors, and disease characteristics in patients with psoriasis

Evaluation of safety profile of the essential oils of eight Heracleum taxa (Apiaceae) related to determined furanocoumarin content

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