Psoriasis concurrent with inflammatory bowel disease

Park, H.S.; Koh, Seong‐Joon; Park, G.Y.; Lee, D.H.; Yoon, Hyun Sun; Youn, Jai Il; Cho, Soyun

doi:10.1111/jdv.12305

Cited by 11 publications

(10 citation statements)

References 39 publications

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“…As previously mentioned, the role of IL‐10 has already been studied in psoriasis as well as IBD . In addition, many studies have already been published which support the association of psoriasis and IBD . Thus, we wanted to determine the possibility of creating a better psoriasis animal model by combining imiquimod‐induced and IL‐10 deficient mice models.…”

Section: Discussionmentioning

confidence: 99%

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Imiquimod‐applied Interleukin‐10 deficient mice better reflects severe and persistent psoriasis with systemic inflammatory state

Jin

Koh

et al. 2017

Experimental Dermatology

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Previous studies have shown that imiquimod-induced psoriasis-like skin inflammation in mice resembles phenotypic changes and cytokine profiles of human psoriasis. However, a psoriasis animal model reflecting the chronic inflammatory course and comorbidities has not yet been established. We aimed to evaluate the imiquimod-applied interleukin (IL)-10 deficient mouse model in comparison with previous models. IL-10 deficient and wild-type (WT) mice received either imiquimod or vehicle cream for 12 days and were sacrificed on day 15. For earlier time point data, either imiquimod or vehicle cream was applied for 2 days, and the mice were sacrificed on day 3. Imiquimod-applied IL-10 deficient mice showed more persistent psoriasis-like inflammation and higher severity index than did WT between day 8 and 15. Histopathologically, they demonstrated significantly thicker epidermis and larger number of CD45+, myeloperoxidase+ and IL-17+ cell counts on day 15. Quantitative reverse transcription-polymerase chain reaction with skin tissue revealed significantly higher imiquimod-induced IL-23p19 expression in imiquimod-applied IL-10 deficient mice on day 15. IL-10 deficient mice also showed significantly higher serum levels of imiquimod-induced IL-17A and tumor necrosis factor-α by enzyme-linked immunosorbent assay on day 15. Furthermore, IL-10 deficient mice showed more prominent increase of spleen weight and decrease of body weight in response to imiquimod application on day 3 and 15. In conclusion, IL-10 deficient mice model with imiquimod application may better reflect severe and persistent psoriasis with systemic inflammatory state.

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Section: Discussionmentioning

confidence: 99%

“…Pathogenesis of psoriasis and IBD share other common mechanisms, as Th 1 and Th 17 pathways, in addition to IL‐10 . Moreover, previous reports also support the association between psoriasis and IBD . Therefore, a new attempt to use IL‐10 deficient mice in psoriasis animal models seems appropriate.…”

Section: Introductionmentioning

confidence: 99%

Imiquimod‐applied Interleukin‐10 deficient mice better reflects severe and persistent psoriasis with systemic inflammatory state

Jin

Koh

et al. 2017

Experimental Dermatology

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“…reported that patients with both psoriasis and IBD tended to have more severe psoriasis and earlier onset, and significantly more PsA and other autoimmune diseases. Another Korean study using the claims database also showed increased prevalence of IBD in the psoriatic population . A meta‐analysis reviewing all ethnic groups also showed a 2.53‐fold increased risk of developing Crohn's disease and a 1.71‐fold increased risk of developing UC …”

Section: Discussionmentioning

confidence: 91%

Prevalence of inflammatory bowel disease in Japanese psoriatic patients

Masaki

Bayaraa

Imafuku

2019

The Journal of Dermatology

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Psoriatic patients reportedly have a higher prevalence of inflammatory bowel disease (IBD); however, there have been few research studies of Japanese psoriatic patients. To elucidate the prevalence of IBD in Japanese psoriatic patients, a cross‐sectional study was performed. Information was collected regarding psoriatic patients with current or prior history of Crohn's disease (CD) or ulcerative colitis (UC) who were treated at Fukuoka University Hospital from 2010 to 2018. Among 681 psoriatic patients (449 men and 232 women), eight (1.2%, six men, two women) had UC and two (0.3%, one man, one woman) had CD. Diagnosis of IBD preceded psoriasis in five patients, while diagnosis of psoriasis preceded IBD in two; the remaining patients’ records did not have sufficient information. Seven of 10 UC‐positive patients had mild psoriasis, two had moderate psoriasis and one had severe psoriasis. When UC‐positive psoriatic patients were compared with IBD‐negative psoriatic patients, there were no differences in age at onset of psoriasis, age at first visit or complications (e.g. psoriatic arthritis, hypertension, hyperlipidemia, hyperuricemia and diabetes). However, UC‐positive patients had significantly higher body mass index (BMI) (26.7 vs 23.7; P = 0.021), compared with patients without IBD. The CD/UC ratio in this cohort was 0.25, while the prevalence of IBD was 1.2%; these values were both lower than those in previous reports involving Caucasian patients. Patients with psoriasis and UC may have higher BMI and milder skin symptoms than those with psoriasis alone. These observations must be further confirmed by controlled domestic studies with larger samples.

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“…Clinically, PsA may also involve enthesitis, tenosynovitis, and dactylitis [2]. Both psoriasis and PsA may have varying degrees of severity, and in humans they have been associated with comorbidities such as cardiovascular disease, stroke, inflammatory bowel disease, depression, and potentially cancer [5,6].…”

Section: Discussionmentioning

confidence: 99%

First Report of Psoriatic-Like Dermatitis and Arthritis in a 4-Year-Old Female Spayed Pug Mix

Regan

Marsella²,

Özmen³

2015

Case Reports in Veterinary Medicine

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Psoriasis manifests as chronic dermatitis and arthritis (PsA) in people. Psoriasis with concurrent PsA is characterized by erythematous, silvery, scaly plaques, especially on the extremities, and concurrent arthritis with enthesitis, tenosynovitis, and dactylitis. To date, no such disease has spontaneously occurred in domestic animals. This case report aims to describe the clinical, radiographic, and histologic appearance of a psoriasis-like dermatitis and psoriatic-like arthritis in a dog. A 4-year-old female spayed pug mix presented for the evaluation of chronic history of hyperkeratotic footpads and deforming arthritis. After ruling out other differential diagnoses and based on the similarity of clinical, radiographic, and histologic findings to human psoriasis and PsA, a tentative diagnosis of psoriasis-like disease was made. Treatment was begun to control pain (tramadol, gabapentin, and carprofen) and psoriatic dermatitis (clobetasol propionate 0.05%, calcipotriene 0.005%, and urea 40% ointment twice daily). Dramatic positive response to treatment was achieved confirming the tentative diagnosis. This case may provide preliminary evidence for the existence of a psoriasis-like condition in dogs and may elucidate treatment options in otherwise refractory cases of chronic dermatitis and polyarthropathy in dogs.

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Psoriasis concurrent with inflammatory bowel disease

Cited by 11 publications

References 39 publications

Imiquimod‐applied Interleukin‐10 deficient mice better reflects severe and persistent psoriasis with systemic inflammatory state

Imiquimod‐applied Interleukin‐10 deficient mice better reflects severe and persistent psoriasis with systemic inflammatory state

Prevalence of inflammatory bowel disease in Japanese psoriatic patients

First Report of Psoriatic-Like Dermatitis and Arthritis in a 4-Year-Old Female Spayed Pug Mix

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