Psoriasis and Vascular Disease: An Unsolved Mystery

Shelling, Michael L.; Federman, Daniel G.; Prodanovich, Srdjan; Kirsner, Robert S.

doi:10.1016/j.amjmed.2008.01.025

Cited by 20 publications

(23 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…4,5 Patients with various inflammatory diseases, including rheumatoid arthritis (RA) and psoriasis, are reported to have a high risk of developing CVD. [6][7][8][9] Rosacea is an inflammatory skin disease with a chronic course. To the best of our knowledge no study has investigated the risk factors for CVD in rosacea patients.…”

Section: Introductionmentioning

confidence: 99%

Rosacea and cardiovascular risk factors: a case control study

Duman

Ersoy‐Evans

Atakan

2013

Acad Dermatol Venereol

102

116

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Rosacea and cardiovascular risk factors: a case control study

Duman

Ersoy‐Evans

Atakan

2013

Acad Dermatol Venereol

102

116

View full text Add to dashboard Cite

show abstract

“…Emotional stress is often linked to onset and/or exacerbation of psoriasis (Kiecolt-Glaser et al, 2003), and approximately 40-80% of psoriatic patients have moderate to severe pruritus (Basavaraj et al, 2011). In addition, the increase in nerve fibers and their secreted neuropeptides involved psoriatic skin (Sugiura et al, 1997), and psoriasis undergoes remission following nerve transection, nerve injury, or decreased nervous system functioning (Shelling et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Nerve growth factor regulates the expression of vascular endothelial growth factor in human HaCaT keratinocytes via PI3K/mTOR pathway

Zhang¹,

Y²

2014

Genet. Mol. Res.

View full text Add to dashboard Cite

ABSTRACT. Decades of research have provided the data to confirm the hypothesis that there is bidirectional communication between the central nervous system and the immune system in psoriasis pathogenesis, but the contribution of the cutaneous neural system remains underexplored. In this study, we evaluated the molecular mechanisms by which nerve growth factor (NGF) regulates hypoxia-inducible factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF) production. The mRNA and protein levels of VEGF secretion from HaCaT cells by NGF were increased in a concentration-dependent manner. In addition, the NGFinduced increase in VEGF is accompanied by an increase in HIF-1α, but not HIF-2α or HIF-1β. However, this increase is abrogated by pretreatment with a mammalian target of rapamycin (mTOR) inhibitor rapamycin. Pharmacologic inhibitors of the Trk tyrosine kinase, PI-3 kinase, and mTOR pathways prevent NGF-stimulated increases in HIF-1α and VEGF. Mutation of the siRNA-mediated silencing of HIF-1α expression blocks NGF-induced increases in VEGF transcription. Our 9325 NGF and VEGF in HaCaT keratinocytes©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 13 (4): 9324-9335 (2014) study indicates that NGF regulates the expression of VEGF through the PI3K/mTOR signaling pathway in human HaCaT keratinocytes.

show abstract

“…Psoriatic patients are at increased cardiovascular risk not only because the disease is frequently associated with hypertension, type 2 diabetes, dyslipidemia and obesity, but also because it is an independent risk factor per se [37]. A large prospective, population-based cohort study clearly showed that psoriasis leads to an independent risk of myocardial infarction, particularly in young patients with a severe disease [40].…”

Section: Psoriasismentioning

confidence: 99%

Interactions between Inflammation and Coagulation in Autoimmune and Immune-Mediated Skin Diseases

Marzano

Tedeschi

Polloni

et al. 2012

CVP

View full text Add to dashboard Cite

Inflammation and coagulation systems are simultaneously activated in autoimmune and immune-mediated skin disorders, and the cross-talk that amplifies and maintains their activation seems to have both local and systemic implications. This interplay occurs in bullous pemphigoid (BP), the prototype autoimmune blistering disease in which eosinophil recruitment and thrombin generation locally contribute to the formation of bullae and inflammatory tissue damage. Moreover, the systemic activation of coagulation may explain the increased thrombotic risk observed in BP patients. Atopic dermatitis (AD), a chronically relapsing immune-mediated inflammatory skin disease, also involves the local and systemic activation of coagulation, which means that a prothrombotic state could theoretically develop, although the incidence of thrombosis is not increased in AD patients probably because of their young age. In psoriasis, a erythematous-squamous inflammatory immune-mediated skin disorder, the activation of coagulation seems to be mainly systemic and related to systemic inflammation, thus potentially contributing to the disease-related increase in cardiovascular risk in this disease. The activation of coagulation has also been suggested an additional pathomechanism in dermatitis herpetiformis (DH), a chronic-relapsing autoimmune skin disease associated with gluten sensitivity and celiac disease, but its precise role has not yet been defined. Taken together, these data provide the rationale for controlled clinical trials aimed at evaluating the usefulness of anticoagulant treatment in autoimmune skin disorders to counteract the local and systemic effects of coagulation activation.

show abstract

Psoriasis and Vascular Disease: An Unsolved Mystery

Cited by 20 publications

References 50 publications

Rosacea and cardiovascular risk factors: a case control study

Rosacea and cardiovascular risk factors: a case control study

Nerve growth factor regulates the expression of vascular endothelial growth factor in human HaCaT keratinocytes via PI3K/mTOR pathway

Interactions between Inflammation and Coagulation in Autoimmune and Immune-Mediated Skin Diseases

Contact Info

Product

Resources

About