Psoriasis and pregnancy outcomes: A nationwide population-based study

Treating Psoriasis During Pregnancy: Safety and Efficacy of Treatments

“…In the study by Yang et al [20], mild psoriasis was not associated with an excess risk of adverse birth outcomes. In a large Danish prospective cohort study of 100,418 pregnancies with a prevalence of psoriasis of 3 %, mild to moderate psoriasis was not found to be a risk factor for fetal death after the first trimester or for prolonged time to pregnancy [23].…”

“…Moderate to severe psoriasis would therefore be expected to influence pregnancy outcomes. Indeed, this has been demonstrated: in a nationwide population-based study of 1463 women, Yang et al [20] found that women with severe psoriasis had an increased risk of low birth weight and Cohen-Barak et al [21] and Ben-David et al [22] have found an increased risk of spontaneous abortion in women with moderate to severe psoriasis; however, these latter two studies were based on small numbers (only ten and 35 women with psoriasis were included, respectively).…”

Inflammatory and glandular skin disease in pregnancy

“…It has been hypothesized that the inflammatory milieu in psoriatics may result in low birth weight or small-for-gestational age infants, as seen in other T h 1-driven diseases, such as rheumatoid arthritis and inflammatory bowel disease. 10 Initial studies did suggest that women with severe psoriasis had increased odds for delivering infants with low birth weight, 10 spontaneous abortions, pregnancy-induced hypertension, and premature rupture of membranes. 11,12 One study contradictorily found that infants of women with psoriasis were large for gestational age, although the authors did not account for maternal obesity.…”

“…Another population-based study in Taiwan reported no increased odds of low birth weight, preterm birth, caesarean section, and hypertension in mothers with mild psoriasis compared to controls. 10 It is reasonable to conclude that mild psoriasis will have minimal impact on fetal health, but moderate to severe psoriasis may lead to negative fetal outcomes, although whether the risk is from psoriasis intrinsically or from the comorbidities remains unclear.…”

Performing research in pregnancy: Challenges and perspectives

“…21 Nevertheless, it is difficult to conclude whether these findings are due to the disease itself or other factors, including therapeutic interventions and associated comorbidities. 22…”