Psoriasis is a common non-infectious disease, considered to be a chronic autoimmune condition, T-cell mediated, characterized by faster replacement of epidermis cells on the basal membrane level, consequently causing inflammation and scaling, affecting 2-3% of population. In palmoplantar psoriasis (PPP) fissures and bleeding aggravate patient's discomfort. Besides conventional dermatologic treatment, many patients choose homeopathic treatment for this condition due to their efficacy and lack of side-effects. In reports on homeopathic treatment of psoriasis the most used medicaments were so called polycrests, or big remedies (like Sulphur, Lycopodium, Natrum muriaticum, etc). In our article we report a case of PPP treated till recovery with a rare homeopathic remedy for this condition, Secale Cornutum, which was prescribed according to individualization of patient signs and symptoms.