Psoriasis and cardiovascular diseases

Vizzardi, Enrico; Raddino, Riccardo; Teli, Melissa; Gorga, Elio; Brambilla, Giulio; Dei, Livio

doi:10.2143/ac.65.3.2050351

Cited by 13 publications

(9 citation statements)

References 20 publications

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“…Although the CHD risk declined over time, the overall risk of CHD remained increased for 10 or more years. The results of our study are in line with previous studies linking rheumatoid arthritis [3] [5] [6] [8] [9] [10] [11] [12], systemic lupus erythematosus [3],[5],[6],[8],[13],[14],[15], Sjögren's disease [3],[5],[6],[16], systemic vasculitis [3],[5], inflammatory bowel disease [3] [5] [8] [17], and psoriasis [8],[18] to an increased risk of CVD. However, our study is unique because it includes a comparison of patients with a wide spectrum of IMDs with the general population in a nationwide setting, as well as a long-term follow-up of patients for CHD.…”

Section: Discussionsupporting

confidence: 91%

“…It is therefore not surprising that inflammatory IMDs such as rheumatoid arthritis (RA) [3],[5],[6],[8],[9],[10],[11],[12] and systemic lupus erythematosus (SLE) [3],[5],[6],[8],[13],[14],[15] have been linked to an increased risk of CVD. An enhanced atherogenesis has also been suggested in several other IMDs such as Sjögren's disease [3],[5],[6],[16], systemic vasculitis [3],[5], inflammatory bowel disease [3],[5],[8] [17], and psoriasis [8], [18].…”

Section: Introductionmentioning

confidence: 89%

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Risk of Subsequent Coronary Heart Disease in Patients Hospitalized for Immune-Mediated Diseases: A Nationwide Follow-Up Study from Sweden

et al. 2012

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BackgroundCertain immune-mediated diseases (IMDs), such as rheumatoid arthritis and systemic lupus erythematosus, have been linked to cardiovascular disorders. We examined whether there is an association between 32 different IMDs and risk of subsequent hospitalization for coronary heart disease (CHD) related to coronary atherosclerosis in a nationwide follow up study in Sweden.Methods and FindingsAll individuals in Sweden hospitalized with a main diagnosis of an IMD (n = 336,479) without previous or coexisting CHD, between January 1, 1964 and December 31 2008, were followed for first hospitalization for CHD. The reference population was the total population of Sweden. Standardized incidence ratios (SIRs) for CHD were calculated. Overall risk of CHD during the first year after hospitalization for an IMD was 2.92 (95% CI 2.84–2.99). Twenty-seven of the 32 IMDs studied were associated with an increased risk of CHD during the first year after hospitalization. The overall risk of CHD decreased over time, from 1.75 after 1–5 years (95% CI 1.73–1.78), to 1.43 after 5–10 years (95% CI 1.41–1.46) and 1.28 after 10+ years (95% CI 1.26–1.30). Females generally had higher SIRs than males. The IMDs for which the SIRs of CDH were highest during the first year after hospitalization included chorea minor 6.98 (95% CI 1.32–20.65), systemic lupus erythematosus 4.94 (95% CI 4.15–5.83), rheumatic fever 4.65 (95% CI 3.53–6.01), Hashimoto's thyroiditis 4.30 (95% CI 3.87–4.75), polymyositis/dermatomyositis 3.81 (95% CI 2.62–5.35), polyarteritis nodosa 3.81 (95% CI 2.72–5.19), rheumatoid arthritis 3.72 (95% CI 3.56–3.88), systemic sclerosis 3.44 (95% CI 2.86–4.09), primary biliary cirrhosis 3.32 (95% CI 2.34–4.58), and autoimmune hemolytic anemia 3.17 (95% CI 2.16–4.47).ConclusionsMost IMDs are associated with increased risk of CHD in the first year after hospital admission. Our findings suggest that many hospitalized IMDs are tightly linked to coronary atherosclerosis.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 89%

Risk of Subsequent Coronary Heart Disease in Patients Hospitalized for Immune-Mediated Diseases: A Nationwide Follow-Up Study from Sweden

et al. 2012

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“…Psoriasis is a common, chronic and inflammatory skin disease with unknown aetiology 1 . In recent years psoriasis has been recognized as a disease associated with several comorbidities and an increased risk of cardiovascular disease 2,3 . Inflammation, oxidative stress and other metabolic changes seem to be involved in the development of complications in patients with psoriasis 4–7 .…”

mentioning

confidence: 99%

Oxidative stress and psoriasis: the effect of antitumour necrosis factor-α inhibitor treatment

Bacchetti¹,

Campanati²,

Ferretti³

et al. 2013

Br J Dermatol

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“…The pathogenesis of CHD is associated with autoimmune activation, which can enhance atherosclerosis (Onat and Yuksel, 2013;Meurice et al, 2016). Patients suffering from an autoimmune disease, such as systemic lupus erythematosus, rheumatoid arthritis or psoriasis, display an increased CHD risk (Levy et al, 2008;Vizzardi et al, 2010;Lopez-Pedrera et al, 2012). For patients without autoimmune diseases, but established CHD, levels of natural autoantibodies against various endogenous epitopes, such as modified LDL, heat shock proteins have been shown to independently predict CHD outcome (Roux-Lombard et al, 2013;Vuilleumier et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Low Level Antibodies Against Alpha-Tropomyosin Are Associated With Increased Risk of Coronary Heart Disease

et al. 2020

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Objective: Natural autoantibodies have been implicated to play a key role in the pathogenesis of coronary heart disease (CHD) because they augment autoimmune activation. The aim of this study was to identify novel specific autoantibodies of CHD, and analyze the relationship between their levels and CHD risk indicators.Approach and Results: First, clinical data and sera from CHD patients were collected. Then, one protein microarray containing 37 proteins that represent candidate autoantigens was developed. The arrays were used to profile autoantibodies in randomly selected sera from 35 samples (20 CHD patients, and 15 healthy controls). After that, microarray data were analyzed and autoantibodies for CHD were screened out. Then, ELISA detection was conducted to validate the differentiable autoantibodies using larger numbers of serum samples (131 CHD patients, and 131 healthy controls). Finally, the associations of antibodies with CHD risk indicator parameters were assessed. Inter-group comparison by microarray indicated that three CHD novel autoantibodies, including glucose-6-phosphate isomerase (G6PI), alphatropomyosin (TPM1), and heterogeneous nuclear ribonucleoprotein D-like (HnRNPDL), were significantly (P < 0.05) increased when compared with the healthy controls. Moreover, a significant increase of IgG autoantibodies for these three autoantigens was confirmed in CHD patients by ELISA (P < 0.0001). The correction analysis revealed a negative correlation of anti-TPM1 antibody levels and total cholesterol (P = 0.0034), and low-density lipoprotein cholesterol (P = 0.0086), respectively.Conclusion: G6PI, TPM1, and HnRNPDL were CHD natural autoantigens, and serum anti-TPM1 antibody could be used as a potential marker to predict the risk for CHD patients.

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Psoriasis and cardiovascular diseases

Cited by 13 publications

References 20 publications

Risk of Subsequent Coronary Heart Disease in Patients Hospitalized for Immune-Mediated Diseases: A Nationwide Follow-Up Study from Sweden

Risk of Subsequent Coronary Heart Disease in Patients Hospitalized for Immune-Mediated Diseases: A Nationwide Follow-Up Study from Sweden

Oxidative stress and psoriasis: the effect of antitumour necrosis factor-α inhibitor treatment

Low Level Antibodies Against Alpha-Tropomyosin Are Associated With Increased Risk of Coronary Heart Disease

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