Psoriasis and Cardiovascular Disease: Two Sides of the Same Coin?

Doumas, Michael; Katsiki, Niki; Papademetriou, Vasilios

doi:10.1177/0003319717702303

Cited by 3 publications

(3 citation statements)

References 60 publications

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“…PSO has been shown to increase the risk of CVD such as myocardial infarction, hypertension, valvular disease, and arrhythmia ( 28 – 34 ). PSO and atherosclerosis share certain common inflammatory pathways, such as endothelial dysfunction, cytokine dysregulation, platelet upregulation, and dyslipidemia ( 17 , 35 ). The available body of evidence suggests the pathogenesis of vascular damage.…”

Section: Discussionmentioning

confidence: 99%

“…Not only can PAOD develop into serious diseases, but it also increases the risk of developing other cardiovascular diseases (CVDs), such as coronary heart disease and myocardial infarction (MI) ( 15 , 16 ). PSO is also associated with the risk of certain CVD, i.e., MI, hypertension, arrhythmia, and valvular disease ( 17 , 18 , 19 ).…”

Section: Introductionmentioning

confidence: 99%

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Association between psoriasis and peripheral artery occlusive disease: a population-based retrospective cohort study

Yeh

Yang

et al. 2023

Front. Cardiovasc. Med.

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IntroductionPsoriasis (PSO) is a chronic skin condition that affects a variety of disorders, especially the cardiovascular system. This study investigated the association between PSO and peripheral arterial disease (PAOD).MethodsA retrospective cohort study design was carried out between 2000 and 2018. The exposure subject was a newly diagnosed PSO. The diagnosis of PSO was never elaborated as a comparison subject. Balanced heterogeneity of the two groups was used by propensity score matching. The cumulative incidence of PAOD between the two groups was performed using Kaplan-Meier analysis. The Cox proportional hazard model was used to measure the risk of PAOD risk hazard ratio.ResultsAfter matching the 1: 1 propensity score, 15,696 subjects with PSO and the same number of subjects without the diagnosis of PSO were recruited. The PSO subject had a higher risk of PAOD than the non-PSO subject (adjusted HR = 1.25; 95% CI = 1.03-1.50). In the 40-64-year-old subgroup, the subject of PSO exhibited an increased risk of PAOD than the subject without PSO.ConclusionPsoriasis is associated with an increased risk of peripheral arterial disease and curative care is necessary to reduce the risk of PAOD..

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association between psoriasis and peripheral artery occlusive disease: a population-based retrospective cohort study

Yeh

Yang

et al. 2023

Front. Cardiovasc. Med.

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“…There is a need to reduce the advancement of fat in the carotid artery and the hardening of the walls of arteries in psoriatic arthritis patients [13]. According to research, exercise also significantly lowers the risk of CVD and psoriatic arthritis disease activity [14].…”

Section: Measures For Managing Cardiovascular Diseases In Case Of Pso...mentioning

confidence: 99%

Psoriasis a Cause of Cardiovascular Diseases: A Review Article

Gupta¹,

Madke²

2022

Cureus

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Psoriasis is a severe, chronic inflammatory disease characterized by erythematous plaques across the extensor surfaces of the skin. Psoriasis has been linked to a higher threat of vascular events like myocardial infarction and stroke. Other associated cardiovascular disorders in the case of psoriasis include building up atherosclerosis, non-ischemic dilated cardiomyopathy, and psoriatic arthritis. Individuals can use International Classification of Diseases (ICD-9) codes to identify cardiovascular disease/comorbidities and related risk factors. The relation between pathophysiology and mechanism of psoriasis and the building up of fat and cholesterol in or on the arterial walls makes the association between psoriasis and cardiovascular diseases more obvious. There is very little research on the adverse effect of systemic treatment of psoriasis on cardiovascular events. Treatment of psoriasis includes mainly biologics and systemic therapy, including methotrexate as a first-line drug. An indirect relation between psoriasis-arthritis and cardiovascular diseases is being noted. Various risk factors contribute to psoriasis and are associated with cardiovascular disease, including smoking, hypertension, and obesity. Personal management to decrease the threat to the cardiovascular system in case of psoriasis can be achieved by changing lifestyle, which includes exercising and avoiding smoking. The criteria for identifying metabolic syndrome are discussed in this review article. Figure Rating Scales (FRS) were used for studying the risk prediction of various cardiovascular diseases. Individuals with atherosclerosis, hypertension and diabetes mellitus type-2 are at a higher risk of developing cardiovascular events and multiple chronic conditions in the case of psoriasis; hence they are part of the population at risk.

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Leptin, cardiovascular diseases and type 2 diabetes mellitus

2018

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Leptin, an adipokine that is implicated in the control of food intake via appetite suppression, may also stimulate oxidative stress, inflammation, thrombosis, arterial stiffness, angiogenesis and atherogenesis. These leptin-induced effects may predispose to the development of cardiovascular diseases. In the present review we discuss the evidence linking leptin levels with the presence, severity and/or prognosis of both coronary artery disease and non-cardiac vascular diseases such as stroke, carotid artery disease, peripheral artery disease (PAD) and abdominal aortic aneurysms (AAA) as well as with chronic kidney disease (CKD) and type 2 diabetes mellitus (T2DM). Leptin levels have been positively associated with the presence, severity, extent and lesion complexity of coronary atherosclerosis as well as with the presence, severity and poor clinical outcomes of both ischemic and hemorrhagic strokes. But conflicting results also exist. Furthermore, leptin was reported to independently predict common carotid intima-media thickness and carotid plaque instability. A link between hyperleptinemia and PAD has been reported, whereas limited data were available on the potential association between leptin and AAA. Elevated leptin concentrations have also been related to CKD incidence and progression as well as with insulin resistance, T2DM, micro- and macrovascular diabetic complications. Statins and antidiabetic drugs (including sitagliptin, metformin, pioglitazone, liraglutide and empagliflozin) may affect leptin levels. Further research is needed to establish the potential use (if any) of leptin as a therapeutic target in these diseases.

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Psoriasis and Cardiovascular Disease: Two Sides of the Same Coin?

Cited by 3 publications

References 60 publications

Association between psoriasis and peripheral artery occlusive disease: a population-based retrospective cohort study

Association between psoriasis and peripheral artery occlusive disease: a population-based retrospective cohort study

Psoriasis a Cause of Cardiovascular Diseases: A Review Article

Leptin, cardiovascular diseases and type 2 diabetes mellitus

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