Psoriasis Among Adolescents in Kuwait and the Role of Siblings, Breastfeeding, and Household Cat and Secondhand Smoke Exposure: A Cross-Sectional Study

Ziyab, Ali H.; Karmaus, Wilfried; AlShatti, Khadijah A.; Al-Kandari, Manal; Hussein, Shaimaa H.; Ali, Yousef

doi:10.1007/s13555-020-00437-0

Cited by 7 publications

(5 citation statements)

References 56 publications

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“…4 The frequency of positive FH of psoriasis ranges from 6.7% to 57.7% in various countries outside Japan. 6,[8][9][10][11][12][13] Although older studies showed a wider range (2.0%-90.9%) of positive FH of psoriasis, 14,15 extreme high and low frequency are uncommon. Farber et al collected data on the frequency of FH of psoriasis from all over the world and found that 11.0% of Japanese patients with psoriasis had FH of psoriasis in 1971.…”

Section: Introductionmentioning

confidence: 99%

“…Psoriatic arthritis (PsA) is another condition with a strong genetic predisposition 4 . The frequency of positive FH of psoriasis ranges from 6.7% to 57.7% in various countries outside Japan 6,8–13 . Although older studies showed a wider range (2.0%–90.9%) of positive FH of psoriasis, 14,15 extreme high and low frequency are uncommon.…”

Section: Introductionmentioning

confidence: 99%

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Clinical characteristics of patients with psoriasis with family history: A multicenter observational study

Ohata

Anezaki

Kaneko

et al. 2023

The Journal of Dermatology

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Clinical characteristics of patients with psoriasis with family history: A multicenter observational study

Ohata

Anezaki

Kaneko

et al. 2023

The Journal of Dermatology

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“…The earliest study showed that almost half of the married couples in Kuwait were consanguineous (11), and the most recent one showed a little decline but still indicated a high number of consanguinity at 46% (10). Some research studies recently reviewed the relationship between consanguinity and increased rate of certain inherited genetic disorders in Kuwait, which include mitochondrial diseases (12)(13), inborn errors of immunity (14)(15), classic homocystinuria, congenital malformations (16-17), primary ciliary dyskinesia (18), retinitis pigmentosa (19), and hyperoxaluria type 1 (20).…”

Section: Introductionmentioning

confidence: 99%

Attitudes of parents with a child with autosomal recessive disease toward consanguinity

Al-Kandari,

Bahzad,

Ramadan

et al. 2024

Preprint

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The major aim of this study is to examine the perspective and attitudes of parents with one or more affected children by an AR disease towards consanguineous marriages. A total of 285 parents were invited to participate in this study. The sample was divided into two groups: clinical sample including parents attending various clinics in hospitals and a community sample. A self-administered survey was developed by researchers. The questionnaire was about the subjects’ attitudes toward consanguinity and was divided into two parts: sociocultural and health attitudes. SPSS was used for data entry and analysis. Chi-square, t-test and Pearson correlation were the major statistical procedures. Significant differences were found between consanguineous parents with at least one affected child with an AR genetic disease and the community sample (non-consanguineous parents). Regarding the prevalence of consanguinity, support consanguinity in general, parents want their children to marry a relative and consanguinity is common in their family, significant differences were also found between clinical and community samples. Regarding health attitudes, significant differences between the two samples were found in six out of seven examined variables. A relationship between the rate of consanguinity and the respondent’s education level was found. High level of inbreeding with increasing consanguinity rates is responsible for the high prevalence of inherited AR genetic disorders in the MENA region with subsequent morbidity and mortality.

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“…Psoriasis is a chronic systemic inflammatory disease. The global age-standardized prevalence of psoriasis is 0.84% 1 ; however, the prevalence of psoriasis in the Gulf Cooperation Council countries tends to be higher, approaching 5.3% in the Kingdom of Saudi Arabia, [2][3] 3.6% in the State of Kuwait, 4 and 1.6% in the Sultanate of Oman. 5 A strong association exists between metabolic syndrome and psoriasis.…”

Section: Introductionmentioning

confidence: 99%

Upregulation of REL and WSB1 in patients with psoriasis and metabolic syndrome

Alsabbagh¹,

Bakhiet²,

Taha³

2023

International Journal of Dermatology and Venereology

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Objective: A strong association exists between metabolic syndrome and psoriasis. The current study was performed to explore the gene regulation of metabolic syndrome in patients with psoriasis.Methods: Patients were assessed for psoriasis and metabolic syndrome clinically (Psoriasis Area and Severity Index, height, weight, waist circumference, and blood pressure) and biochemically (lipid profile and fasting blood sugar concentration). Systemic gene regulation was first explored by microarray and analyzed using Transcriptome Analysis Console Software, after which two selected upregulated genes were further validated using polymerase chain reaction and enzyme-linked immunosorbent assay and analyzed using independent sample t test.Results: The analysis showed 7,269 upregulated and 3 downregulated genes at a fold change of 2 and P value of < 0.05; only 17 genes were upregulated and none were downregulated at a fold change of 8 and P value of < 0.005. Comparison with 22 previously reported potential biomarkers of metabolic syndrome in patients with psoriasis showed that the levels of 16 biomarkers aligned with the gene regulation observed in the current study. In particular, the REL transcript was upregulated 12-fold (P = 8.16 × 10 −17 ), while the WSB1 transcript was upregulated 9-fold (P = 9.87 × 10 −13 ). Validation showed that REL was also upregulated 2-fold in the polymerase chain reaction, and its protein was expressed at 7.140 ng/mL vs. undetectable levels in the cases (P = 0.048). However, WSB1 was upregulated 2-fold in the polymerase chain reaction compared with controls, and unexpectedly, its protein was undetectable in cases but detectable in controls (P = 0.018). Conclusion:The upregulation of REL and WSB1 was observed in patients with psoriasis and metabolic syndrome, the clinical application of REL and WSB1 as biomarkers needs further validation for potential future implications in clinical practice.

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Psoriasis Among Adolescents in Kuwait and the Role of Siblings, Breastfeeding, and Household Cat and Secondhand Smoke Exposure: A Cross-Sectional Study

Cited by 7 publications

References 56 publications

Clinical characteristics of patients with psoriasis with family history: A multicenter observational study

Clinical characteristics of patients with psoriasis with family history: A multicenter observational study

Attitudes of parents with a child with autosomal recessive disease toward consanguinity

Upregulation of REL and WSB1 in patients with psoriasis and metabolic syndrome

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