Psoralen: A Biologically Important Coumarin with Emerging Applications

Abstract

: Coumarin has a place with a class of lactones which are fundamentally comprising of a benzene ring fused to αpyrone ring, known as benzopyrones. It likewise has a conjugated framework with electron rich and good charge-transport properties. It is delivered by plants to shield themselves from predation as a chemical response. Despite the fact that, coumarins have been utilized in different products like cosmetics, additives, perfumes, aroma enhancers in various tobaccos and some alcoholic drinks their most relevant role in natural products, organic and medicinal chemistry. Besides, as medicinal candidates a lot of coumarin compounds with strong pharmacological activity and low toxicity and high bioavailability and better curative effects, etc. has been used to treat various types of diseases.Various endeavors have been done to create coumarin-based anticoagulant, antimicrobial, antioxidant, anticancer, anti-diabetic, anti-neurodegenerative, analgesic and anti-inflammatory agents. A class of chemical compounds called as furocoumarins having phototoxic properties found in nature synthesized by plants by fusion of coumarin to a furan ring in different plant species. Psoralens belong to the furocoumarin class which occurs naturally in various plants e.g. lemons, limes, and parsnips. Angelicin is one of the isomers of psoralens and generally most of the furocoumarins are derivatives of psoralens or angelicin. e.g. xanthotoxin, bergapten, and nodekenetin. The present work demonstrated that Psoralen molecules not just have only have anti-tumoral activity against breast cancer yet in addition influence different intracellular signals which maintain high survival of breast cancer cells. Psoralens performs different functions e.g. antagonize metabolic pathways, protease enzymes, cell cycle progression and even interfere in the crosslinking between receptors and growth factor mitogenic signaling.

Oxypeucedanin: Chemotaxonomy, Isolation, and Bioactivities

“…Regarding the phototoxic activities of some linear furanocoumarins, majorly psoralen, bergapten, and xanthotoxin [ 119 ], more investigations focusing on the effect and toxicity of OP could be of interest. Until now, several studies have reported the adverse effects of some furanocoumarins that are caused by undesirable interactions with certain drugs, particularly furanocoumarins rich in grapefruit [ 9 ], but no similar study has been performed to analyze OP, and indeed this can also be considered a futuristic research aim.…”

Chinese Herbal Medicine Formula Guizhi Li-Zhong Tang as an Alternative to Antibiotic Feed Additives for Preventing Pneumonia in Piglets through Antioxidant, Anti-Inflammatory, and Antiapoptotic Protection

“…Chromatographic investigation of Guizhi in our previous research [ 20 ] revealed that its bioactive substances are coumarin, cinnamic acid, cinnamaldehyde, and 2-methoxycinnamaldehyde. Coumarin has been used in various products and candidate drugs because coumarin compounds have high bioavailability and both antioxidant and anti-inflammatory properties [ 23 ]. Cinnamic acid and its derivatives (such as ferulic acid and cinnamic amide) have attracted substantial attention due to their antioxidative, anti-inflammatory, and neuroprotective properties [ 24 ].…”

Medicinal Plants for the Treatment of Gastrointestinal Cancers From the Metabolomics Perspective

“…It was found that IA reversed phospholipid metabolism, glycerophospholipid catabolism, and arachidonic acid metabolism through HIF-1α/SREBP-1, revealing that lipid metabolism may be associated with the antineoplastic effects of IA on CRC. Psoralen is a kind of biologically important coumarin derived from the fruits of Psoralea corylifolia L., which has been shown to reverse the multidrug-resistance (MDR) of HCC ( Thakur et al, 2020 ). However, the low solubility and poor stability of psoralen limit its wide use.…”