Psoas Muscle Volume as an Opportunistic Diagnostic Tool to Assess Sarcopenia in Patients with Hip Fractures: A Retrospective Cohort Study

So, Sang-Pil; Lee, Bum-Sik; Kim, Ji Wan

doi:10.3390/jpm11121338

Cited by 9 publications

(9 citation statements)

References 30 publications

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“…In CRC, there are reports on use of PV and PA for post-chemoradiotherapy rectal cancer and postoperative complications [22][23][24][25][26], but we could not nd any studies on long-term prognosis and 5-year survival rate in elderly patients with CRC. In this regard, our study is novel in addressing these perspectives.…”

Section: Discussionmentioning

confidence: 91%

“…In PA measurement, the measured height may not correspond to the maximum area, and signi cant variations can occur depending on the level of measurement [23,24]. So et al argued that 3D assessments in patients with hip fractures are more accurate for evaluating muscle mass compared to 2D methods [25]. On the other hand, one report suggested that both PA and PV are effective [26].…”

Section: Discussionmentioning

confidence: 99%

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Use of 3D-CT-Derived Psoas Major Muscle Volume in Defining Sarcopenia in Colorectal Cancer

Takahashi,

Sakamoto,

Kogure

et al. 2023

Preprint

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Background Sarcopenia is characterized by reduced skeletal muscle volume and is a condition that is prevalent among elderly patients and associated with poor prognosis as a comorbidity in malignancies. Given the aging population in Japan, an understanding of malignancies, including colorectal cancer (CRC), complicated by sarcopenia is increasingly important. Therefore, the focus of this study is on a novel and practical diagnostic approach of assessment of psoas major muscle volume (PV) using 3-dimensional computed tomography (3D-CT) in diagnosis of sarcopenia in patients with CRC. Methods The subjects were 150 patients aged 80 or older with CRC who underwent primary tumor resection at Juntendo University Hospital between 2004 and 2017. 3D-CT measurement of PV and conventional CT measurement of the psoas major muscle cross-sectional area (PA) were used to identify sarcopenia (group S) and non-sarcopenia (group nS) cases. Clinicopathological characteristics, operative results, postoperative complications, and prognosis were compared between these groups. Results The S:nS ratios were 15:135 for the PV method and 52:98 for the PA method. There was a strong positive correlation (r = 0.66, p < 0.01) between PVI (psoas major muscle volume index) and PAI (psoas major muscle cross-sectional area index), which were calculated by dividing PV or PA by the square of height. Surgical results and postoperative complications did not differ significantly in the S and nS groups defined using each method. Overall survival was worse in group S compared to group nS identified by PV (p < 0.01), but not significantly different in groups S and nS identified by PA (p = 0.77). A Cox proportional hazards model for OS identified group S by PV as an independent predictor of a poor prognosis (p < 0.05), whereas group S by PA was not a predictor of prognosis (p = 0.60). Conclusions The PV method for identifying sarcopenia in elderly patients with CRC is more practical and sensitive for prediction of a poor prognosis compared to the conventional method.

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Use of 3D-CT-Derived Psoas Major Muscle Volume in Defining Sarcopenia in Colorectal Cancer

Takahashi,

Sakamoto,

Kogure

et al. 2023

Preprint

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“…However, psoas muscle is originated from T12 and inserted to femur. Scanning from chest to lower limbs is required for the exact evaluation of psoas muscle and muscle mass at the mid-level of psoas muscle, taken from abdominal scanning, has been used in the previous studies ( 17 , 18 ). Additionally, scanning increased the risk for the exposure of biohazard.…”

Section: Discussionmentioning

confidence: 99%

Prediction of postoperative pulmonary complications in older patients undergoing lobectomy for lung cancer based on skeletal muscle mass

Hong¹,

Lee²,

Kim³

2023

J Thorac Dis

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Background: This retrospective study was designed to evaluate preoperative pulmonary function test (PFT) results and skeletal muscle mass, represented by the erector spinae muscle (EM), as predictors of postoperative pulmonary complications (PPCs) in older patients undergoing lobectomy for lung cancer. Methods:The medical records, including preoperative PFT, chest computed tomography (CT) and PPCs, of patients older than 65 years undergoing lobectomy for lung cancer were retrospectively examined at Konkuk University Medical Center from January 2016 to December 2021. The sum of cross-sectional areas (CSAs) of the right and left EMs at the level of the spinous process with the 12 th thoracic vertebra was used as the skeletal muscle mass (CSA Both ).Results: Data from a total of 197 patients were included in the analyses. In total, 55 patients had PPCs.The preoperative functional vital capacity (FVC) and forced expiratory volume in 1 second (FEV1) showed significantly poorer values and the CSA Both had significantly lower values in patients with than in those without PPCs. The preoperative FVC and FEV1 showed significant positive correlations with CSA Both .Multiple logistic regression analysis identified age, diabetes mellitus (DM), preoperative FVC and CSA Both as risk factors for PPCs. The areas under the curves for FVC and CSA Both were 0.727 (95% CI, 0.650-0.803; P<0.001) and 0.685 (95% CI, 0.608-0.762; P<0.001), respectively. The optimal threshold values of FVC and CSA Both to predict PPCs based on a receiver operating characteristic curve analysis were 2.685 L (sensitivity =64.1% and specificity =61.8%) and 28.47 mm 2 (sensitivity =62.0% and specificity =61.5%), respectively.Conclusions: PPCs in older patients undergoing lobectomy for lung cancer were associated with lower preoperative FVC and FEV1 values and a lower skeletal muscle mass. Skeletal muscle mass, represented by the EM, was significantly correlated with the preoperative FVC and FEV1. Therefore, skeletal muscle mass may be useful for the prediction of PPCs in patients undergoing lobectomy for lung cancer.

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“…Recently, given the improvement of technology, three-dimensional psoas muscle volume has been proposed as an alternative to the above conventional index. The psoas muscle volume is strongly correlated with the cross-sectional total muscle area at the horizontal height of L3, and its decrease with age, as with dual-energy X-ray absorptiometry and bioelectrical impedance analysis muscle mass measurements, has also been observed [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

Prognostic Impact of Psoas Muscle Mass Index following Trans-Catheter Aortic Valve Replacement

Imamura

Fujioka

Ushijima

et al. 2023

JCM

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Background: Psoas muscle mass is a recently featured index of sarcopenia, which has a negative prognostic impact in patients with a variety of diseases. We investigated the prognostic impact of baseline psoas muscle mass in patients receiving a trans-catheter aortic valve replacement (TAVR). Methods: Patients who received TAVR at our center between 2015 and 2022 were included. Patients received computer tomography imaging upon admission as an institutional protocol, and psoas muscle mass was measured, which was indexed by body surface area. Patients were followed for four years or until January 2023. The prognostic impact of psoas muscle mass index on 4-year mortality following index discharge was evaluated. Results: A total of 322 patients (85 years, 95 male) were included. Median psoas muscle mass index at baseline was 10.9 (9.0, 13.5) × 10 cm3/m2. A lower psoas muscle mass index tended to be associated with several index of malnutrition and sarcopenia. A psoas muscle mass index was independently associated with 4-year mortality with an adjusted hazard ratio of 0.88 (95% confidence interval 0.79–0.99, p = 0.044). Patients with lower psoas muscle mass index (below the statistically calculated cutoff of 10.7 × 10 cm3/m2, N = 152) had significantly higher cumulative 4-year mortality compared with others (32% versus 13%, p = 0.008). Conclusions: A lower psoas muscle mass index, which is a recently featured objective marker of sarcopenia, was associated with mid-term mortality following TAVR in the elderly cohort with severe aortic stenosis. The measurement of psoas muscle mass index prior to TAVR could have clinical implications for shared decision-making among patients, their relatives, and clinicians.

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Psoas Muscle Volume as an Opportunistic Diagnostic Tool to Assess Sarcopenia in Patients with Hip Fractures: A Retrospective Cohort Study

Cited by 9 publications

References 30 publications

Use of 3D-CT-Derived Psoas Major Muscle Volume in Defining Sarcopenia in Colorectal Cancer

Use of 3D-CT-Derived Psoas Major Muscle Volume in Defining Sarcopenia in Colorectal Cancer

Prediction of postoperative pulmonary complications in older patients undergoing lobectomy for lung cancer based on skeletal muscle mass

Prognostic Impact of Psoas Muscle Mass Index following Trans-Catheter Aortic Valve Replacement

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