Psoas Muscle Abscess Causing Fever of Unknown Origin: The Value of Tc-99m (V) DMS Imaging

Lee, Bi-Fang; Chen, Chung‐Jen; Yang, Cheng‐Hong; Yu, Hsin-Chieh

doi:10.1097/00003072-199711000-00017

Cited by 6 publications

(1 citation statement)

References 5 publications

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“…Most importantly, the result can be obtained within hours of DMSA scanning. Recently, three infectious cases in cluding one intra-abdominal abscess, one peritonitis, and one psoas muscle abscess have been reported to be detected by a DMSA scan [21][22][23]. Moreover, a study by Lee et al [20] revealed very high diagnostic sensitivity, specifi city, and an accuracy of 95%, 94%, and 95%, respectively, in the detection and localization of intestinal infl ammation using a DMSA scan.…”

Section: Discussionmentioning

confidence: 99%

The value of Tc-99m (V) dimercaptosuccinic acid in detecting intra-abdominal infection: compared with gallium scan

2007

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Section: Discussionmentioning

confidence: 99%

The value of Tc-99m (V) dimercaptosuccinic acid in detecting intra-abdominal infection: compared with gallium scan

2007

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Evaluation of Tc‐99m (V) DMSA Binding to Human Plasma Proteins

Lee

Yeh

Chiu

et al. 2008

The Kaohsiung J of Med Scie

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As a critical step toward elucidating the mechanism of localization of Tc-99m (V) dimercaptosuccinic acid (DMSA), we investigated its binding and transport in blood in comparison with Ga-67 citrate. The studies were performed in vitro by incubating Tc-99m (V) DMSA with blood (one sample at 4 degrees Celcius and another at 37 degrees Celcius) to assess its binding to plasma proteins using ultrafiltration, dialysis, electrophoresis, gel filtration chromatography and affinity chromatography. A parallel experiment for determining the blood binding of Ga-67 citrate was performed using the same procedures. Using ultrafiltration, dialysis, electrophoresis and gel filtration chromatography, labeled plasma samples showed that protein binding for Tc-99m (V) DMSA was 45-54% at 37 degrees Celcius and 73-80% at 4 degrees Celcius. The figures for Ga-67 citrate were 43-53% at 37 degrees Celcius and 75-81% at 4 degrees Celcius. Electrophoresis showed that Tc-99m (V) DMSA was mostly bound to plasma albumin (36.05 +/- 2.48% at 37 degrees Celcius and 60.04 +/- 1.87% at 4 degrees Celcius), and that the proportion of Ga-67 radioactivity associated with beta-globulin was 34.23 +/- 1.37% at 37 degrees Celcius and 55.71 +/- 3.69% at 4 degrees Celcius. In affinity chromatography experiments, Tc-99m (V) DMSA did not bind to transferrin, unlike Ga-67 citrate. This study demonstrates that, at the radiopharmaceutical tracer level, most Tc-99m (V) DMSA in blood is protein-bound, primarily to albumin, but not to transferrin. In contrast, Ga-67 citrate was bound primarily to transferrin. The knowledge that albumin is the main transport protein of Tc-99m (V) DMSA may contribute to a better understanding of its biodistribution and pharmacokinetics.

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Mediastinal Neurilemmoma Demonstrated by Positive Tc-99m(V) DMSA SPECT and Negative Ga-67 Uptake

Lee

Chiu²,

Huang

et al. 2000

Clinical Nuclear Medicine

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Psoas Muscle Abscess Causing Fever of Unknown Origin: The Value of Tc-99m (V) DMS Imaging

Cited by 6 publications

References 5 publications

The value of Tc-99m (V) dimercaptosuccinic acid in detecting intra-abdominal infection: compared with gallium scan

The value of Tc-99m (V) dimercaptosuccinic acid in detecting intra-abdominal infection: compared with gallium scan

Evaluation of Tc‐99m (V) DMSA Binding to Human Plasma Proteins

Mediastinal Neurilemmoma Demonstrated by Positive Tc-99m(V) DMSA SPECT and Negative Ga-67 Uptake

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