PSMA-targeted NIR probes for image-guided detection of prostate cancer

Cilibrizzi, Agostino; Wang, Julie; Memdouh, Siham; Iacovone, Antonella; McElroy, Kate L.; Jaffar, Noor; Young, John P.; Hider, Robert C.; Blower, Philip J.; Al‐Jamal, Khuloud T.; Abbate, Vincenzo

doi:10.1016/j.colsurfb.2022.112734

Cited by 7 publications

(6 citation statements)

References 44 publications

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“…Eder et al also developed a PSMA-targeted NIRF dye, Glu-urea-Lys-2-Nal-Chx-Lys (IRDye800CW)-DOTA (PSMA-927), based on the theranostic agent PSMA-617 99 (Table 5 ). Moreover, PSMA-Cy7.5-2 outperformed PSMA-IRDye800CW in vitro and in vivo 100 .…”

Section: Psma-fgsmentioning

confidence: 89%

Prostate-specific membrane antigen-targeted surgery in prostate cancer: Accurate identification, real-time diagnosis, and precise resection

Jiao,

Zhang,

Wen

et al. 2024

Theranostics

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Radical prostatectomy (RP) combined with pelvic lymph node dissection (PLND) is the first step in multimodal treatment of prostate cancer (PCa) without distant metastases. For a long time, the surgical resection range has been highly dependent on the surgeon's visualization and experience with preoperative imaging. With the rapid development of prostate-specific membrane antigen positron emission tomography and single-photon emission computed tomography (PSMA-PET and PSMA-SPECT), PSMA-targeted surgery has been introduced for a more accurate pathological diagnosis and complete resection of positive surgical margins (PSMs) and micro-lymph node metastases (LNMs). We reviewed PSMA-targeted surgeries, including PSMA-PET-guided prostatic biopsy (PSMA-TB), PSMA-targeted radio-guided surgery (PSMA-RGS), PSMA-targeted fluorescence-guided surgery (PSMA-FGS), and multi-modality/multi-targeted PSMA-targeted surgery. We also discuss the strengths and challenges of PSMA-targeted surgery, and propose that PSMA-targeted surgery could be a great addition to existing surgery protocols, thereby improving the accuracy and convenience of surgery for primary and recurrent PCa in the near future.

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Section: Psma-fgsmentioning

confidence: 89%

Prostate-specific membrane antigen-targeted surgery in prostate cancer: Accurate identification, real-time diagnosis, and precise resection

Jiao,

Zhang,

Wen

et al. 2024

Theranostics

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“…BODIPY or Cy7.5-based probes targeting PSMA have also been reported (Figure 4(a), left). 93,94 Histone deacetylases (HDACs) are epigenetic enzymes that are responsible for the deacetylation of lysine residues in histones and are overexpressed in cancers such as hepatocellular carcinoma (HCC). 95,96 In 2020, Tang et al focused on fluorescence probes targeting HDAC6.…”

Section: Always-on Probes For Cancer Imagingmentioning

confidence: 99%

“…This probe, 800CW-SCE, labeled PSMA-positive LNCaP cultured cells, but did not label PSMA-negative PC3 cells (Figure (b)), and could visualize LNCaP tumors in mice (Figure (c)). BODIPY or Cy7.5-based probes targeting PSMA have also been reported (Figure (a), left). , …”

Section: Introductionmentioning

confidence: 99%

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Activity-Based Fluorescence Diagnostics for Cancer

Fujita,

Urano

2024

Chem. Rev.

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Fluorescence imaging is one of the most promising approaches to achieve intraoperative assessment of the tumor/normal tissue margins during cancer surgery. This is critical to improve the patients' prognosis, and therefore various molecular fluorescence imaging probes have been developed for the identification of cancer lesions during surgery. Among them, "activatable" fluorescence probes that react with cancer-specific biomarker enzymes to generate fluorescence signals have great potential for high-contrast cancer imaging due to their low background fluorescence and high signal amplification by enzymatic turnover. Over the past two decades, activatable fluorescence probes employing various fluorescence control mechanisms have been developed worldwide for this purpose. Furthermore, new biomarker enzymatic activities for specific types of cancers have been identified, enabling visualization of various types of cancers with high sensitivity and specificity. This Review focuses on recent advances in the design, function and characteristics of activatable fluorescence probes that target cancer-specific enzymatic activities for cancer imaging and also discusses future prospects in the field of activity-based diagnostics for cancer. CONTENTS

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“…The development of functional near-infrared (NIR)-emitting fluorescent probes for image-guided surgery as well as multimodal imaging and personalized medicine is of great interest for biomedical applications and life sciences research. Some of the essential design requirements for these imaging probes for in vivo applications have recently been reviewed. − In the NIR region of the electromagnetic spectrum, scattering coefficients, absorption, and autofluorescence of biological tissues reach local minima, resulting in overall low attenuation and allowing for larger penetration depths of the emitted light. − Most prominent commercially accessible dyes for imaging in this region are those based on pentamethine and heptamethine cyanine frameworks, as well as the closely related tricarbocyanine dyes. ,,− The latter offer an additional handle for functionalization if the meso -position features a halide. , Such dyes are highly reactive, with substitution reactions in the meso -position believed to proceed via an S RN 1-type mechanism . In this context, derivatization of this Cy7 site can drastically alter the photophysical properties, due to substantial changes of the charge distribution along the polymethine backbone .…”

mentioning

confidence: 99%

Unraveling the Chemistry of meso-Cl Tricarbocyanine Dyes in Conjugation Reactions for the Creation of Peptide Bonds

Exner

Cortezon‐Tamarit

et al. 2022

ACS Bio Med Chem Au

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Tricarbocyanine dyes have become popular tools in life sciences and medicine. Their near-infrared (NIR) fluorescence makes them ideal agents for imaging of thick specimens or in vivo imaging, e.g., in fluorescence-guided surgery. Among other types of cyanine dyes, meso-Cl tricarbocyanine dyes have received a surge of interest, as it emerged that their high reactivity makes them inherently tumor-targeting. As such, significant research efforts have focused on conjugating these to functional moieties. However, the syntheses generally suffer from low yields. Hereby, we report on the reaction of meso-Cl dyes with a small selection of coupling reagents to give the corresponding keto-polymethines, potentially explaining low yields and the prevalence of monofunctionalized cyanine conjugates in the current state of the art of functional near-infrared dyes. We present the synthesis and isolation of the first keto-polymethine-based conjugate and present preliminary investigation in the prostate cancer cell lines PC3 and DU145 by confocal microscopy and discuss changes to optical properties in biological media.

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PSMA-targeted NIR probes for image-guided detection of prostate cancer

Cited by 7 publications

References 44 publications

Prostate-specific membrane antigen-targeted surgery in prostate cancer: Accurate identification, real-time diagnosis, and precise resection

Prostate-specific membrane antigen-targeted surgery in prostate cancer: Accurate identification, real-time diagnosis, and precise resection

Activity-Based Fluorescence Diagnostics for Cancer

Unraveling the Chemistry of meso-Cl Tricarbocyanine Dyes in Conjugation Reactions for the Creation of Peptide Bonds

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