Psilocybin – Summary of knowledge and new perspectives

Tylš, Filip; Páleníček, Tomáš; Horáček, Jiří

doi:10.1016/j.euroneuro.2013.12.006

Cited by 201 publications

(210 citation statements)

References 108 publications

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“…It has a long history of use as a recreational drug on the basis of its ability to produce hallucinogenic states resembling those seen with LSD, but what is more surprising is that it can apparently produce positive and long-lasting changes in behaviour 97 . An often-noted effect is an increase in 'openness' , a personality trait that includes a broad-minded and tolerant attitude towards others 98 .…”

Section: Truth and Morality In Bottles?mentioning

confidence: 98%

The warrior in the machine: neuroscience goes to war

Tracey

Flower

2014

Nat Rev Neurosci

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Ever since Stone Age men discovered that knapping flint produced sharp stone edges that could be used in combat as well as for cooking and hunting, technological advances of all kinds have been adapted and adopted by the military.The opportunities provided by modern neuroscience are proving no exception, but their application in a military context is accompanied by complex practical and ethical considerations.

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Section: Truth and Morality In Bottles?mentioning

confidence: 98%

The warrior in the machine: neuroscience goes to war

Tracey

Flower

2014

Nat Rev Neurosci

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“…In this vein, ketamine as well as other new fast-acting antidepressants could exert their fast antidepressant effect through their ability to manipulate body's response to external and internal stimuli (14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24). Similarly, conventional antidepressants and psilocybin might function through monoamine related pain pathways (25)(26)(27). However, shifting maladaptative states of the body make it an elusive goal to achieve remission, which could be supported by research findings such as distinct changes in depressive symptoms upon ketamine administration between depressed and healthy subjects (28).…”

Section: Discussionmentioning

confidence: 99%

Short but Continuous Natural Pain during Meditation Sittings for Depression Treatment: A Case Report

Huang¹

2018

Preprint

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Major depressive disorder (MDD) is a common mental disorder, which results in seriously impaired condition in the patients and great global disability burden. In light of its quite diverse etiologies, comorbidity with many other diseases, and complex underlying pathology, it has been a great challenge to understand the physiological basis of MDD, which may be a complex of related diseases, rather than a single one. In addition to the partial understanding of MDD, the individual heterogeneities among patients may render the development of a universal treatment an elusive goal. But studying how each of currently available treatments affects the disease can generate useful information to stratify patients into different subtypes for individualized treatments. In this case report, we present the first report of repeated success of using meditation as the only treatment of MDD, compared to initial success but no remission with other conventional antidepressants on the same patient. We hypothesized that the short but continuous natural pain during one-hour meditation sittings has the therapeutic effect to treat depression in the case of this patient and potentially others with MDD. This special opportunity of eliminating tremendous heterogeneity among different individuals has enabled us to probe deeply into the potential mechanism of depression treatments and the complex physiology of depression itself, both of which have likely profound implications in the treatment of other MDD patients as well. More importantly, this case report helps us dissect one specific component of meditation for its longknown and well-established benefit against depression. Preprints (www.preprints.org) | NOT PEER-REVIEWED |

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“…By means of a central serotonin receptor, as well as dopaminergic, among others, they induce perception changes, modifications in meanings as well as in the emotionality associated to memories that occasionally end up in transcendental experiences (Tylš, Páleníček & Horáček, 2014). On a peripheral level, they cause a sympathomimetic syndrome: nausea and vomiting, tachycardia, elevation of blood pressure and/or of body temperature, in direct relation with the dosage used (Hasler, Grimberg, Benz, Huber & Vollenweider, 2004).…”

Section: Hallucinogenic Mushrooms: Psilocybe Spmentioning

confidence: 99%

An approach to the new psychoactive drugs phenomenon

Dolengevich-Segal

Rodríguez-Salgado

Gómez-Arnau

et al. 2017

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Background. The new psychoactive drugs (NPD) are those that represent a danger to public health and are not prohibited by conventions on international narcotics. The concept also includes new contexts and new routes of consumption as well as novel ways of distribution, notably Internet. The risks associated with NPD consumption are largely unknown to users and to health care providers. Objective. To integrate the existing evidence regarding the main NPD in terms of description, epidemiology, psychopharmacology, medical complications and psychoactive effects. Method. To review relevant and updated clinical information on NPD obtained from specialized books and indexed scientific journals (PubMed/Medline, Google Scholar, Scopus), as well as official documents edited by international organizations dedicated to the epidemiologic analysis of drug abuse and Internet websites and forums managed by psychoactive substance users. Results. Aspects of clinical and pharmacological interest are described comprehensively, together with epidemiological data and risks associated to the consumption of the most relevant NPD: synthetic cannabinoids, synthetic cathinones, NBOMe series, indoleamines, piperazines, hallucinogenic mushrooms (Psilocybe SP.), synthetic opioids, plant products (khat, kratom, Salvia divinorum, ayahuasca) and dissociative anesthetics. Discussion and conclusion. The emergence of the NPD is a phenomenon on the rise with important consequences for public health. Learning about new trends in drug consumption and its potential risks should be essential for the medical professional. New research is needed in order to understand the phenomenon of the NPD and its pharmacological, clinical and legal implications.

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Psilocybin – Summary of knowledge and new perspectives

Cited by 201 publications

References 108 publications

The warrior in the machine: neuroscience goes to war

The warrior in the machine: neuroscience goes to war

Short but Continuous Natural Pain during Meditation Sittings for Depression Treatment: A Case Report

An approach to the new psychoactive drugs phenomenon

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