Psidium guajava L. (Common Guava) Peel, Pulp and Leaves as Natural Sources of
Antioxidants, Antimicrobials and Photoprotective Agents for
Development of Sun Protection Cosmeceuticals

Dewage, D.D.D.H.; Samarakoon, S.M.G.K.; Karunaratne, S.H.S.; Rajapakse, C. S. K.

doi:10.14233/ajchem.2023.24058

Cited by 3 publications

(3 citation statements)

References 33 publications

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“…Jassal et al [42] reported that the IC 50 of DPPH radical scavenging of guava leaf essential oil was 445 ± 0.001 µg/mL which was lower than our results. Dewage et al [43] studied the antioxidant activity of the guava leaf through DPPH assay and the resultant IC 50 was 90.07 ± 0.73 µg/mL and when compared to our results with methanolic extract (78.93 ± 0.46 µg/mL) it was very low. Similarly, Jani et al [27] recorded the DPPH radical scavenging capacity of Psidium guajava with an IC 50 of 45.52 µg/mL.…”

Section: Free Radical Scavenging Potential Of Guava Cultivarssupporting

confidence: 46%

Nutritional Composition, Mineral Profiling, In Vitro Antioxidant, Antibacterial and Enzyme Inhibitory Properties of Selected Indian Guava Cultivars Leaf Extract

Sam Arul Raj,

Amalraj,

Alarifi

et al. 2023

Pharmaceuticals

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Psidium guajava L. is a small evergreen tree known for its magnificent medicinal and nutritional value. This study aimed to evaluate the nutritional profile and in vitro pharmacological potentialities of the different leaf extracts of four cultivars of Psidium guajava namely Surka chitti, Allahabad safeda, Karela, and Lucknow-49. The standard procedures of the Association of Official Analytical Chemists (AOAC) were followed to carry out the nutritional analysis and all of the cultivars recorded the presence of elements at a nominal range. The highest presence of phenols (125.77 mg GAE/g) and flavonoids (92.38 mg QE/g) in the methanolic leaf extract of the Karela cultivar was recorded. A wide range of minerals such as sodium, phosphorus, magnesium, zinc, and boron were recorded with a higher percentage in the Karela cultivar of Psidium guajava. In the enzyme inhibitory assays, Allahabad safeda showed potential inhibition with an IC50 of 113.31 ± 1.07, 98.2 ± 0.66 and 95.73 ± 0.39 μg/mL in α-amylase, α-glucosidase, and tyrosinase inhibition assays, respectively. The strong antioxidant effect was established by Lucknow-49 (IC50 of 74.43 ± 1.86 μg/mL) and Allahabad safeda (IC50 of 78.93 ± 0.46 μg/mL) for ABTS and DPPH assays, respectively. The ethyl acetate and methanolic leaf extracts of the Allahabad safeda cultivar showed better inhibition against Pseudomonas aeruginosa with an MIC of 14.84 and 28.69 µg/mL, respectively. A decent mean zone of inhibition was recorded in methanolic leaf extract that ranged from 21–25 mm in diameter against the tested bacterial strains (Proteus vulgaris, Bacillus subtilis, and P. aeruginosa). This is the first scientific report on the comparative and comprehensive analysis of indigenous guava cultivars to evidently shortlist the elite cultivars with enriched dietary nutrition and biological activities.

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Section: Free Radical Scavenging Potential Of Guava Cultivarssupporting

confidence: 46%

Nutritional Composition, Mineral Profiling, In Vitro Antioxidant, Antibacterial and Enzyme Inhibitory Properties of Selected Indian Guava Cultivars Leaf Extract

Sam Arul Raj,

Amalraj,

Alarifi

et al. 2023

Pharmaceuticals

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“…The highest AAI in all fractions was given by the G3 treatment, compared to the control (G0). Dewage et al (2022) reported that the methanol extract of Psidium guajava fruit in India gave the highest antioxidant activity results compared to other plants with an IC50 value of 1.33 mg/mL. Antioxidant activity of crystal guava with G0 and G3 treatments was higher than that of tomatoes from Toraja (Mu'nisa, 2012).…”

Section: Dpph Radical Scavenging Activity Of Crystal Guava (Psidium G...mentioning

confidence: 99%

Crystal guava (Psidium guajava L. “Crystal”) treated with gibberelic acid (GA3) : Evaluation of in vitro antioxidant capacities

Sumi Lestari,

Pemimpin Hutagaol,

Srikandi

2023

J. Pendidik. Kim

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Free radicals can cause many diseases, such as cancer. Antioxidant is a compound that could scavenge free radicals. One of the natural source antioxidants is guava. The application of gibberellic acid (GA3) is known to affect the physicochemical properties and antioxidant content of the fruit. The goals of this research were to investigate the antioxidant activity of skin, flesh and fruit of crystal guava were given additional GA3 treatment with concentration 0; 60; 120; 180; 240; and 300 ppm by determining the value of the Antioxidant Activity Index (AAI) using DPPH; evaluate the total phenolic content (TPC), ferric reducing antioxidant power (FRAP) and physicochemical properties; analyse the correlation between the TPC with AAI DPPH by Pearson’s method. Extraction was performed by the maceration method using acetone 50% mixed with a magnetic stirrer for 1 h. Determination of AAI DPPH, FRAP and the TPC was performed by UV-Visible spectrophotometry. TPC in the flesh and fruit fractions tended to increase and FRAP values in all fractions decreased with GA3 application. The highest TPC and FRAP was given by the G3 treatment on the skin fraction and G0 treatment on the skin fraction. The highest AAI in all fractions was given by the G3 treatment. The TPC was significantly positively correlated with the AAI DPPH of the flesh and fruit fraction extracts (0.250 ≤ r ≤ 0.880), and the skin fraction extracts showed a strong negative correlation between TPC and AAI DPPH (-0.813 < r < -0.973).

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“…A disk diffusion method is used to measure the antimicrobial property of two concentrations of ethanol-extracted guava extract against S. aureus. This method is known to be the most widely used method for determining antimicrobial resistance around the world [9]. The procedure involves seeding a lawn of bacteria on the surface of an agar medium with paper disks saturated with the antimicrobial compound.…”

Section: Instrumentsmentioning

confidence: 99%

Analysis of gauze pad made from coconut tree fiber infused with guava derived phenolic compounds

Suarez,

Peñamante,

Carrillo

et al. 2024

IOP Conf. Ser.: Earth Environ. Sci.

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Gauze pad wound dressing plays a crucial role in protecting the wound and preventing it from factors that can prolong the healing process. However, due to the porous nature of gauze pads, it cannot completely block microbes from getting into the wound. This study analyzes coconut tree fiber as a gauze pad infused with guava derived phenolic compounds, known for its antimicrobial and antioxidant properties. The research assesses the extract’s effectiveness, focusing on phenolic compounds, antioxidant properties, and antimicrobial effects. By employing the disk diffusion method against Staphylococcus aureus, the study reveals that both 50% and 30% extracts exhibit inhibitory activity, with mean zones of inhibition at 8.5 mm and 8.33 mm, respectively, showing the antimicrobial property for both 50% and 30% extracts. The samples also demonstrated notable DPPH radical scavenging capacities for concentrations ranging from 0.006 to 1.27 (%w/v) for the 50% extract sample and from 0.006 to 1.25 for the 30% extract sample, ranging from 1.98% to 68.5% and 7.94% to 69.5%, respectively, indicating antioxidant property for both samples. The researchers have determined that there is no significant difference (p-value = 0.9187, α = 0.05) between the scavenging activity of both 50% and 30% extract. Furthermore, a minimal disparity in total phenolics was observed, with the former containing 1.25 and the latter 1.24 weight percent gallic acid. To determine if there is any negative skin reaction, a patch test was conducted in collaboration with a dermatologist using Stanford Health Care Medicine Standard. The test revealed no adverse skin reactions after three days of no removal usage of the coconut tree fiber gauze pad infused with phenolic compounds, as compared to a commercially available gauze pad. This study underscores the promise of guava extract and its antibacterial properties, particularly against skin pathogens, and its safe application when integrated with coconut fiber. This combination holds potential as a natural antimicrobial agent with diverse applications.

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Psidium guajava L. (Common Guava) Peel, Pulp and Leaves as Natural Sources of Antioxidants, Antimicrobials and Photoprotective Agents for Development of Sun Protection Cosmeceuticals

Cited by 3 publications

References 33 publications

Nutritional Composition, Mineral Profiling, In Vitro Antioxidant, Antibacterial and Enzyme Inhibitory Properties of Selected Indian Guava Cultivars Leaf Extract

Nutritional Composition, Mineral Profiling, In Vitro Antioxidant, Antibacterial and Enzyme Inhibitory Properties of Selected Indian Guava Cultivars Leaf Extract

Crystal guava (Psidium guajava L. “Crystal”) treated with gibberelic acid (GA3) : Evaluation of in vitro antioxidant capacities

Analysis of gauze pad made from coconut tree fiber infused with guava derived phenolic compounds

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