Pseudoxanthomatous mastocytosis

Griffiths, W.A.D.; Daneshbod, Khosrow

doi:10.1111/j.1365-2133.1975.tb06482.x

Cited by 26 publications

(18 citation statements)

References 3 publications

(1 reference statement)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Griffiths and Daneshbod [11] described in 1975 a patient with disseminated yellow nodules with a negative Darier's sign and coined the term "pseudoxanthomatous mastocytosis" in allusion to the similarity of the lesions to xanthomas and pseudoxanthoma elasticum. The authors considered this descriptive term more appropriate than "xanthelasmoid mastocytosis" although they assumed that their case only differs from that described by Tilbury Fox in the persistence of their patient's lesions.…”

Section: Discussionmentioning

confidence: 98%

“…The introduction of different descriptive terms regarding cutaneous mastocytoses [5][6][7][8][9][10][11] has contributed to create some confusion among physicians. The term "xanthelasmoid mastocytosis" ("xanthelasmoidea") was coined by Fox in 1875 [5] to describe the presence of yellowish papules or nodules which resembled xanthelasma (he stated "acute general xanthelasma" would be a term that "would roughly describe the disease" in the cases he reported).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Coexistence of two types of clinical lesions in childhood-onset mastocytosis

Pérez-Pérez¹,

Allegue²,

Caeiro³

et al. 2011

Indian J Dermatol Venereol Leprol

View full text Add to dashboard Cite

The vast majority of mastocytosis appear in childhood, urticaria pigmentosa (UP) and mastocytomas being the most common types. Terms such as "xanthelasmoid mastocytosis", "pseudoxanthomatous mastocytosis" or "nodular mastocytosis" have been introduced in the literature to describe the presence of yellowish papular or nodular lesions. We describe two children with cutaneous mastocytosis showing yellowish lesions in combination with other skin lesions. A 10-year-old girl presented with asymptomatic lesions in her vulva at birth, and developed brownish macules on her trunk years after. An eight-year-old boy presented with multiple yellowish papular lesions on his trunk, neck and limbs coexisting with a few clinically anetodermic lesions. No systemic involvement was found and the skin biopsy confirmed a cutaneous mastocytosis in both cases. The two patients are currently asymptomatic and are being periodically followed up. Mastocytoses may show a variety of clinical lesions, sometimes leading to misdiagnosis. Although there are previous reports, involvement of the mucosae and secondary anetoderma are not common findings in cutaneous mastocytoses. We consider that cutaneous manifestations of mastocytoses compose a clinical spectrum, thus explaining the coexistence of different clinical lesions and the development of uncommon presentations.

show abstract

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Coexistence of two types of clinical lesions in childhood-onset mastocytosis

Pérez-Pérez¹,

Allegue²,

Caeiro³

et al. 2011

Indian J Dermatol Venereol Leprol

View full text Add to dashboard Cite

show abstract

“…Diagnosis is confirmed on the basis of clinical features and characteristic histopathological findings. Clinical differential diagnosis includes pseudoxanthoma elasticum 3 and, in tropical countries, lepromatous leprosy and post‐kala‐azar dermal leishmaniasis.…”

Section: Discussionmentioning

confidence: 99%

Pseudoxanthomatous mastocytosis

Srivastava¹,

Chand²,

Singh³

2007

Int J Dermatology

View full text Add to dashboard Cite

A 50‐year‐old woman presented with itchy, multiple, flat, yellowish, waxy papules and plaques diffusely involving her face, trunk, and upper extremities for 5 years (Fig. 1). Itching was moderate to severe in intensity and was episodic, without any identifiable aggravating or relieving factors. On rubbing the lesions with a blunt object erythema was elicited. Her ophthalmological examination was normal. Her complete hemogram was normal along with other routine investigations. Patient's slit skin smear for acid‐fast bacilli and rk39 dip‐stick ELISA for post‐kala‐azar dermal leishmaniasis were negative. Ultrasound examination of her abdomen was normal and skeletal survey showed no evidence of bony changes. Histological examination showed diffuse dense infiltrate of numerous mast cells filling up the papillary dermis and most of upper‐ and mid‐reticular dermis. Overlying epidermis showed moderate epidermal hyperplasia and hyperpigmentation. There was sparse scattering of neutrophils within the infiltrate. Extracellular mast cells granules were also seen (Fig. 2). Diagnosis of diffuse cutaneous mastocytosis of pseudoxanthomatous variety was made. 1 Pretreatment photographs of the patient; (a) face; (b) trunk 2 Histopathology showing dense diffuse infiltrate of numerous mast cells filling up the papillary dermis and most of the upper and mid‐reticular dermis (H&E; a, ×100; b, ×400) The patient was prescribed treatment in the form of H1 and H2 blockers (fexofenadine and ranitidine) and trimethylpsoralen and ultraviolet A (PUVA) photochemotherapy. After 2 months of treatment, there has been marked improvement in the appearance and itching.

show abstract

“…When lesions are generalized, they may have a maculo-papular appearance (urticaria pigmentosa), a diffuse or erythrodermic presentation (diffuse cutaneous mastocytosis), or a telangiectatic aspect (telangiectasia macular eruptiva perstans). Atypical and infrequent presentations of mastocytosis have been described, including bullous lesions (more frequent in early ages) (3), pseudoxanthomatous or xanthelasmoidea (4,5), without clinically evident lesions (6), with a crocodile-like pachydermic aspect of skin (7), giant inguinal and suprapubic masses (8), congenital symptomatic dermographism (9), and with an anetoderma-like aspect (10).…”

Section: Introductionmentioning

confidence: 99%

Anetodermic mastocytosis: Response to PUVA therapy

Pozo¹,

Pimentel

Paradela³

et al. 2007

Journal of Dermatological Treatment

View full text Add to dashboard Cite

Mastocytosis is a group of disorders characterized by the accumulation of mast cells in different tissues and organs. The skin is the most frequently involved organ (90% of cases) where mastocytosis may show a heterogenic clinical expression. Anetodermic lesions are an unusual clinical presentation of mastocytosis. We report a case of anetodermic mastocytosis in a 26-year-old man, with sparse lesions and a benign course. PUVA therapy obtained excellent results in this case. Darier's sign should be investigated in patients with anetodermic lesions of unclear origin in order to exclude cutaneous mastocytosis.

show abstract

Pseudoxanthomatous mastocytosis

Abstract: A case of xanthelasmoidea (pseudoxanthomatous mastocytosis) occurring in a 50-year-old Iranian man is described. The patient had a large upper gastrointestinal haemorrhage.

Cited by 26 publications

References 3 publications

Coexistence of two types of clinical lesions in childhood-onset mastocytosis

Coexistence of two types of clinical lesions in childhood-onset mastocytosis

Pseudoxanthomatous mastocytosis

Anetodermic mastocytosis: Response to PUVA therapy

Contact Info

Product

Resources

About