“…Trypanosomes possess all the conventional eukaryotic small RNA types such as U snRNAs ( Liang et al., 2003 ; Rajan et al., 2019a , 2019b ), snoRNAs ( Chikne et al, 2016 , 2019 ; Michaeli et al., 2012 ; Rajan et al., 2020 ), telomerase RNA ( Gupta et al., 2013a ; Sandhu et al., 2013 ), 7SL RNA ( Michaeli, 2014 ), and Vault RNA ( Kolev et al., 2019 ). Surprisingly, trypanosomes possess almost double the number of snoRNAs compared to yeast, which have a similar genome-size ( Rajan et al., 2019a , 2019b ). Pseudouridines guided by H/ACA snoRNAs, are developmentally regulated, with higher levels in the BSF, enabling the parasite to cope with the temperature shift while cycling between the hosts ( Chikne et al., 2016 ).…”