Pseudotumor cerebri in idiopathic aplastic anemia

Nazir, Sayeda A.; Siatkowski, R. Michael

doi:10.1067/mpa.2003.s1091853102420149

Cited by 11 publications

(7 citation statements)

References 2 publications

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“…Child 10 presented with headache, diplopia, and a petechial rash. Aplastic anaemia was confirmed by bone marrow aspirate, a known cause of secondary intracranial hypertension, and steady state pressure study showed an ICP of 40mmHg.…”

Section: Resultsmentioning

confidence: 92%

Idiopathic intracranial hypertension in childhood: pitfalls in diagnosis

Krishnakumar

Pickard

Czosnyka

et al. 2014

Develop Med Child Neuro

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ABBREVIATIONS CSFISCerebrospinal METHOD We reviewed the records of all children referred with symptoms and/or signs consistent with raised intracranial pressure (ICP) and normal magnetic resonance imaging of the brain to our tertiary neurology unit over 4 years. IIH was confirmed after expert ophthalmology including ultrasound/tomography and advanced cerebrospinal fluid (CSF) pressure studies. RESULTSOf 15 children (six males, nine females; median age 12y, range 3-15y), six (five females, one male) were confirmed to have IIH. All weighed above the 91st centile and were over 10 years old. Four of the six had raised ICP secondary to other causes. Four had been misdiagnosed locally with papilloedema, three had drusen, and one had 'crowded discs'. Two had raised CSF pressures on standard lumbar puncture, but 20-minute steady state and infusion studies were normal, with symptoms settling after therapy was withdrawn.INTERPRETATION Misdiagnosis of IIH was frequent, but could be reduced by (1) expert ophthalmological fundoscopy, orbital ultrasound, and optical coherence tomography; (2) expert neuroradiology; and (3) assessment of steady state CSF pressure rather than standard opening pressure in centimetres of water.

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Section: Resultsmentioning

confidence: 92%

Idiopathic intracranial hypertension in childhood: pitfalls in diagnosis

Krishnakumar

Pickard

Czosnyka

et al. 2014

Develop Med Child Neuro

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“…In studies, researchers describe an association between several types of anemia and papilledema or increased ICP 9,11,12,[31][32][33][34] along with other forms of anemia, including iron deficiency anemia, 35,36 pernicious anemia, 37 hemolytic anemia, 38 and sickle cell anemia. 33 The majority of symptoms resolve with treatment of the underlying condition.…”

Section: Discussionmentioning

confidence: 99%

“…Severe anemia can cause retinopathy characterized by diffuse intraretinal hemorrhages 8 ; previous case reports have described papilledema in AA. [9][10][11][12] Two main mechanisms of anemia-induced ICP have been proposed. First, overcirculation of blood through the choroid plexus (due to elevated cardiac output occurring secondary to anemia) can cause cerebrospinal fluid (CSF) overproduction.…”

Section: Ophthalmology Was Consulted For Blurry Vision and Optic Discmentioning

confidence: 99%

A Child With Pancytopenia and Optic Disc Swelling

Hall¹,

Stroh²,

Armstrong³

et al. 2019

Pediatrics

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“…Optic disc edema has been reported to occur in 6% of cases of aplastic anemia, with the etiology most likely being related to elevated intracranial pressure [ 6 ]. Two separate case reports describe the occurrence of idiopathic intracranial hypertension in 3 adolescent patients with aplastic anemia, which responded to management with acetazolamide and correction of the anemia [ 8 , 9 ]. A recent retrospective case series further highlighted this relationship by describing 7 cases of improvement of papilledema associated with anemia by correction of anemia alone.…”

Section: Discussionmentioning

confidence: 99%