Pseudoscleroderma associated with transforming growth factor β1–producing advanced gastric carcinoma: Comment on the article by Varga

Fujii, Tomoyuki; Mimori, Tsuneyo; Kimura, Noriko; Satoh, Shinji; Hirakata, Michito

doi:10.1002/art.11018

Cited by 8 publications

(3 citation statements)

References 120 publications

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“…The most compelling hypothesis attributes SSc development to cancer-induced autoimmunity. It is also postulated that certain cancer cells may produce biologically active substances such as transforming growth factor β (TGF-β), which has long been implicated in fibrotic pathology [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

Paraneoplastic systemic sclerosis associated with colorectal carcinoma

2018

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A number of rheumatic disorders may appear as paraneoplastic syndromes, the most common being dermatomyositis or polymyositis. Systemic sclerosis is associated with a slightly increased risk of cancer, although its direct association with malignancies is controversial. We describe a case of a 57-year-old male with rectal adenocarcinoma and systemic sclerosis. Close temporal relationship between the initial presentation and parallel course of both conditions, as well as atypically rapid progression of systemic sclerosis symptoms, were observed in the reported case. The strict relation between these two conditions suggested that systemic sclerosis was a paraneoplastic syndrome rather than a concomitant morbidity in the presented patient. Current literature on systemic sclerosis coexisting with colorectal tumours is very limited, especially in the paraneoplastic setting.

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Section: Discussionmentioning

confidence: 99%

Paraneoplastic systemic sclerosis associated with colorectal carcinoma

2018

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“…Pseudoscleroderma associated with transforming growth factor (TGF)‐ β 1, producing gastric cancer, was reported by Fujii et al . in 2003 6 . They described that TGF‐ β 1 messenger RNA was detected in the carcinomatous site but not in the normal gastric sites, and in post‐tumour resection patients, total skin thickness score (TSS) improved and plasma TGF‐ β 1 was decreased.…”

mentioning

confidence: 99%

Fasciitis-panniculitis syndrome and advanced gastric adenocarcinoma in association with antibodies to single-stranded DNA

Ido¹,

Kiyohara²,

Sawai³

et al. 2006

British Journal of Dermatology

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“…In addition, transforming growth factor‐β (TGF‐β) is considered to play an important role in the pathogenesis of SSc, 11 and increased levels of TGF‐β observed in the plasma and ascitic fluid of patients with advanced ovarian carcinoma 12 . Furthermore, improvement of skin sclerosis has been reported in a case of pseudoscleroderma after the treatment of TGF‐β secreting gastric adenocarcinoma 13 . Although TGF‐β levels were not assessed in our case, they might be associated with sclerosis of the skin.…”

Section: Systemic Sclerosis (Ssc) and Ovarian Cancer; Previously Repomentioning

confidence: 99%