Pseudorabies Virus Variant in Bartha-K61–Vaccinated Pigs, China, 2012

An, Tongqing; Peng, Jinmei; Tian, Zhen; Zhao, Hongyuan; Li, Na; Liu, Yimin; Chen, Jiazeng; Leng, Chaoliang; Sun, Yan; Chang, Dan; Tong, Guangzhi

doi:10.3201/eid1911.130177

Cited by 282 publications

(275 citation statements)

References 12 publications

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“…The results demonstrated that the Bartha-K61 vaccine could effectively protect against lethal challenge with the traditional PRV SH2010 strain, but not against the emerging PRV variant strain SH2012. These findings are consistent with those of other studies [3,11].…”

Section: Discussionsupporting

confidence: 83%

“…This suggested that the PR vaccine was not effective against wild-type PR infection. According to recent studies, the causative agent of the outbreak was a PRV variant that showed enhanced pathogenicity [3,7,8,10]. In the present study, the PRV strain SH2012 was isolated in 2012 from an infected pig farm in Shanghai, China that used the typical vaccine.…”

Section: Discussionmentioning

confidence: 99%

“…The causative agent of the outbreaks was confirmed to be a PRV variant [3,9]. The PRV variant was shown to be both antigenically different from the classical PRVs and more pathogenic in older pigs [3,7,8,10]. Previous studies on immunological protection in sheep have shown that the Bartha-K61 vaccine does not provide complete protection against the emerging PRV variant, but could offer full protection against infection with PRV strain SC (an earlier virulent strain in China) [3,11].…”

Section: Introductionmentioning

confidence: 99%

“…However, in October 2011, a severe PRV outbreak occurred in Bartha-K61-vaccinated pig herds on many Chinese farms, resulting in considerable economic losses [5][6][7][8]. The causative agent of the outbreaks was confirmed to be a PRV variant [3,9]. The PRV variant was shown to be both antigenically different from the classical PRVs and more pathogenic in older pigs [3,7,8,10].…”

Section: Introductionmentioning

confidence: 99%

“…In response, the Bartha-K61 vaccine strain was introduced to China in the late 1970s [2]. From the 1990s to 2010, the Bartha-K61 vaccine was widely used in Chinese pig herds and PR was effectively controlled [3,4]. However, in October 2011, a severe PRV outbreak occurred in Bartha-K61-vaccinated pig herds on many Chinese farms, resulting in considerable economic losses [5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Experimental Infection of Sheep With Pseudorabies Viruses Isolated In Shanghai, China, Between 2010 and 2012

Ju¹,

Yang²,

Wang³

et al. 2017

Eur J Exp Bio

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For many years, pseudorabies has been efficiently controlled in China by vaccination. However, a sudden outbreak occurred on many pig farms during 2012-2013. In this study, phylogenetic analysis was carried out with the aim of understanding the genetic relatedness between strains in both populations and comparing strains in China with those circulating in other countries. To obtain more pathogenetic relevant data regarding two pseudorabies virus (PRV) isolates (SH2010 and SH2012) in sheep, we evaluated samples of PRV isolated in Shanghai, China between 2010 and 2012. Based on clinical signs, body temperature variation, and the maximum amounts of viral DNA in unvaccinated/infected sheep, the emerging PRV variant strain, SH2012 was observed to be more highly virulent than the traditional PRV SH2010 strain. The data of the present study will aid in a better understanding of the differences in pathogenicity between the traditional PRV SH2010 strain and the emerging PRV variant strain SH2012.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Experimental Infection of Sheep With Pseudorabies Viruses Isolated In Shanghai, China, Between 2010 and 2012

Ju¹,

Yang²,

Wang³

et al. 2017

Eur J Exp Bio

View full text Add to dashboard Cite

show abstract

Advances in mRNA vaccines for viral diseases

Huang

Zhu

Guo

et al. 2023

Journal of Medical Virology

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Since the onset of the pandemic caused by severe acute respiratory syndrome coronavirus 2, messenger RNA (mRNA) vaccines have demonstrated outstanding performance. mRNA vaccines offer significant advantages over conventional vaccines in production speed and cost-effectiveness, making them an attractive option against other viral diseases. This article reviewed recent advances in viral mRNA vaccines and their delivery systems to provide references and guidance for developing mRNA vaccines for new viral diseases.

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Label‐Free Quantitative Proteomic Analysis of Differentially Expressed Membrane Proteins of Pulmonary Alveolar Macrophages Infected with Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus and Its Attenuated Strain

Gao

et al. 2017

Proteomics

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Significant differences exist between the highly pathogenic (HP) porcine reproductive and respiratory syndrome virus (PRRSV) and its attenuated pathogenic (AP) strain in the ability to infect host cells. The mechanisms by which different virulent strains invade host cells remain relatively unknown. In this study, pulmonary alveolar macrophages (PAMs) are infected with HP‐PRRSV (HuN4) and AP‐PRRSV (HuN4‐F112) for 24 h, then harvested and subjected to label‐free quantitative MS. A total of 2849 proteins are identified, including 95 that are differentially expressed. Among them, 26 proteins are located on the membrane. The most differentially expressed proteins are involved in response to stimulus, metabolic process, and immune system process, which mainly have the function of binding and catalytic activity. Cluster of differentiation CD163, vimentin (VIM), and nmII as well as detected proteins are assessed together by string analysis, which elucidated a potentially different infection mechanism. According to the function annotations, PRRSV with different virulence may mainly differ in immunology, inflammation, immune evasion as well as cell apoptosis. This is the first attempt to explore the differential characteristics between HP‐PRRSV and its attenuated PRRSV infected PAMs focusing on membrane proteins which will be of great help to further understand the different infective mechanisms of HP‐PRRSV and AP‐PRRSV.

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Pseudorabies Virus Variant in Bartha-K61–Vaccinated Pigs, China, 2012

Cited by 282 publications

References 12 publications

Experimental Infection of Sheep With Pseudorabies Viruses Isolated In Shanghai, China, Between 2010 and 2012

Experimental Infection of Sheep With Pseudorabies Viruses Isolated In Shanghai, China, Between 2010 and 2012

Advances in mRNA vaccines for viral diseases

Label‐Free Quantitative Proteomic Analysis of Differentially Expressed Membrane Proteins of Pulmonary Alveolar Macrophages Infected with Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus and Its Attenuated Strain

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