Pseudorabies virus infection in mink: A host-specific pathogenesis

Marcaccini, A.; López-Peña, Mónica; Quiroga, María Isabel; Bermúdez, Roberto; Nieto, J. M.; Alemañ, Nuria

doi:10.1016/j.vetimm.2008.03.013

Cited by 59 publications

(48 citation statements)

References 33 publications

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“…Histopathologic and immunohistochemical findings were similar to those previously reported [3,7,12,17] . Naturally, this disease is transmitted from swine to cattle.…”

Section: Discussionsupporting

confidence: 89%

“…Disease is fatal in many wild and domestic animals such as cattle, sheep, goats, cats, dogs, horses and mainly in swines. It is an acute viral disease characterized by central nervous system symptoms [1][2][3][4][5][6][7] .…”

Section: Discussionmentioning

confidence: 99%

“…It is also a zoonotic disease in humans. It is an acute viral disease characterized by central nervous system symptoms [1][2][3][4][5][6][7] . The disease in cattle is commonly referred as "mad itch" because of the severe pruritus [2] .…”

Section: Introductionmentioning

confidence: 99%

“…It produces intensely in brain and causes encephalomyelitis. Thus, it leads to death in a short time [7,11] . Clinically in cattle, symptoms such as severe local pruritus, intensely licking the pruritic location and rubbing desire of this location to places, biting, plucking its own flesh (automutilation) are reported.…”

Section: Introductionmentioning

confidence: 99%

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Van’da Bir İnekte Yalancı Kuduz (Aujeszky) Hastalığının İmmunohistokimyasal Teşhisi

Yıldırım¹,

Özkan²,

Yener³

et al. 2016

Kafkas Univ Vet Fak Derg

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Aujeszky's disease, also known as pseudorabies, is caused by an alphaherpesvirus that infects the central nervous system and other system. Disease was first recognized as a fatal viral disease of cattle and dogs in 1902. The natural infections have been reported worldwide in swine, cattle, dogs and variety of wildlife species in more recent years. The study material was a 5 years old cow which was brought with symptoms such as skin itching, weakness, convulsions, fever and neurogical signs. As a result of the clinical examination the animal was suspected for Aujeszky's disease. Slaughter and necropsy were recommended. Subsequent to necropsy, tissues were fixed in formalin. Samples were evaluated histopathologically and immunohistochemically. According to the histopathological findings; diffuse, nonsuppurative inflammation of brain, spinal cord and spinal nerves were determined. Brain lesions were detected commonly in cerebral and cerebellar cortexes. Grey and white matter were both affected. It was observed marked perivascular lymphoplasmocytic cell infiltration, glial cell proliferation, Hyperemia and hemoragia in veins in brain and light chromatolysis have been identified in some neurons. Intranuclear inclusions were observed in neurons. On the skin itching region of animal, serofibrinous inflammation in the dermis and subcutis was detected. According to the immunohistochemical findings; immunoperoxidase was detected strong positive in cytoplasms of both neurons and glial cells in areas with meningitis in brain. Consequently; after clinical, macroscopical and microscopical examination, this case was diagnosed as Aujeszky's disease. The aim of this study is presenting this disease immunochemically as it has never been reported in cattle in Turkey. We believe that it would be appropriate to present this case report since it is the first Pseudorabies case in cattle in Turkey. Keywords: Aujeszky's disease, Histopathology, Immunohistochemistry, Pseudorabies Van'da Bir İnekte Yalancı Kuduz (Aujeszky) Hastalığının İmmunohistokimyasal Teşhisi ÖzetPseudorabies olarak da bilinen Aujeszky hastalığı, etkeni alphaherpesvirus olan ve merkezi sinir sistemi ile diğer sistemleri enfekte eden bir hastalıktır. Hastalık ilk olarak 1902 yılında sığır ve köpeklerde ölümcül bir viral hastalık olarak tanımlanmıştır. Hastalık yakın zamanda tüm dünyada domuz, sığır, köpek ve çeşitli yabani hayvanlarda bildirilmiştir. Bu çalışmanın amacı, Türkiye'de sığırlarda bildirimi olmayan bu hastalığı immunokimyasal olarak ortaya koymaktır. Çalışmanın materyalini, halsizlik, deride şiddetli kaşıntı, yüksek ateş, şiddetli konvulziyon ve sinirsel semptomlara sahip 5 yaşında bir inek oluşturdu. Klinik muayene sonucu hayvanda Aujeszky hastalığından şüphelenildi. Hayvana kesim ve nekropsi önerildi. Nekropsi sonrası alınan dokular formalinde fikse edildi. Dokular histopatolojik ve immunohistokimyasal olarak değerlendirildi. Histopatolojik olarak; beyinde spinal kortta ve spinal sinirlerde diffuz non-suppuratif meningoensefalitis belirlendi. Beyi...

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“…Histopathologic and immunohistochemical findings were similar to those previously reported [3,7,12,17] . Naturally, this disease is transmitted from swine to cattle.…”

Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Van’da Bir İnekte Yalancı Kuduz (Aujeszky) Hastalığının İmmunohistokimyasal Teşhisi

Yıldırım¹,

Özkan²,

Yener³

et al. 2016

Kafkas Univ Vet Fak Derg

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“…O vírus encontrava-se na forma latente e a reativação poderia ter sido facilitada por diversos fatores do manejo, como estresse, aplicação de medicamentos imunossupressores, mudanças bruscas de temperatura, outras infecções, transporte, dentre outros (Aleman et al 2001, Posadas & Martinez 2005, Marcaccini et al 2008.…”

Section: Resultsunclassified

Estratégia para erradicação de focos da Doença de Aujeszky em suínos no Estado de São Paulo

Oliveira¹,

Oliveira

Alexandrino

et al. 2012

Pesq. Vet. Bras.

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Este trabalho teve como objetivo a avaliação de duas estratégias para erradicação de focos da doença de Aujeszky (DA) em suínos criados comercialmente no estado de São Paulo. Foram identificados dois focos da enfermidade, no município de Cerqueira César, um apresentando somente animais sororreagentes (Foco 1) e outro, casos clínicos da doença (Foco 2). Foram avaliadas duas estratégias de erradicação, uma por eliminação dos sororreagentes e outra por despovoamento gradual, com acompanhamento durante 12 meses. A erradicação por eliminação dos sororreagentes foi aplicada no Foco 1 e compreendeu na identificação por exame sorológico, isolamento e abate dos positivos; vacinação dos negativos e reposição no plantel com animais provenientes de propriedade livre. No início dos trabalhos, 68% do plantel era positivo e ao final 51%. No Foco 2 utilizou-se o despovoamento gradual, onde todos os animais foram enviados ao abate sanitário, realizado vazio sanitário nas instalações, seguido pelo repovoamento com animais livres. Esta última estratégia, nas condições desse trabalho, mostrou-se a mais eficaz, pois erradicou a DA.

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