Pseudopolyposis in Ulcerative Colitis

Jalan, K. N.; Walker, Robert J.; Sircus, W.; McManus, J. P. A.; Prescott, R. J.; Card, W.I.

doi:10.1016/s0140-6736(69)90260-8

Cited by 64 publications

(51 citation statements)

References 22 publications

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“…Inflammatory pseudopolyps usually occur in ulcerative colitis, and less frequently in Crohn's disease [8,9,12,29]. The condition is thought to represent regenerating mucosal islands scattered between areas of extensive ulceration.…”

Section: Discussionmentioning

confidence: 99%

A Retrospective Study of Inflammatory Colorectal Polyps in Miniature Dachshunds

Ohmi

Tsukamoto

Ohno

et al. 2012

The Journal of Veterinary Medical Science

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ABSTRACT. Medical records of dogs with colorectal polyps were retrospectively reviewed, and clinical presentation of inflammatory colorectal polyps in miniature dachshunds was evaluated. Of 33 dogs found to have colorectal polyps, miniature dachshunds were markedly over-represented with 16 dogs (48%), of which 12 (75%) were found to have inflammatory polyps. Multiple polyps localized between the rectum and the descending colon was the most common finding in miniature dachshunds with inflammatory polyps. Twenty dogs (80%) out of 25 miniature dachshunds with inflammatory colorectal polyps responded to immunosuppressive therapy using prednisolone and cyclosporine. The results of this study indicate that miniature dachshunds are predisposed to develop inflammatory colorectal multiple polyps, for which immunosuppressive therapy may be a treatment option. Polyps are an abnormal growth of tissue arising from the mucosa, including neoplasms and inflammatory polyps. In dogs, colorectal polyps are relatively common in the gastrointestinal tract. These polyps can be single or multiple and are most often located in the distal rectum, causing the common clinical signs of hematochezia or tenesmus. In previous reports, many colorectal polyps in dogs were found to be derived from neoplasms, with adenomatous polyps and adenocarcinoma being most frequently represented [11,25,32,33]. Adenomatous polyps and adenocarcinoma are observed as solitary masses in the rectum, and most polyps appear as friable, lobulated, sessile, or pedunculated lesions on the mucosa. Surgical resection has been recommended in dogs as treatment for colorectal polyps [2,5,21]. Endoscopic treatment for adenomatous polyps [7,10] and piroxicam for tubulopapillary polyps [15] have been reported as alternative therapies for colorectal neoplasms. On the contrary, inflammatory colorectal polyps are rare, and few reports have described the clinical features of inflammatory colorectal polyps [33]. In humans, inflammatory colorectal polyps or polypoid lesions occur in association with inflammatory bowel disease (IBD) and other inflammatory diseases of the colon such as ischemic or infective colitis [3,17,24]. These masses form mainly due to extensive mucosal damage and healing processes, rather than infiltration of inflammatory cells. The polyps formed from infiltration of inflammatory cells, which could be termed "true" inflammatory polyps, seem to be relatively rare in humans.This study was conducted on the basis of two objectives. First, we retrospectively investigated dogs with colorectal polyps to characterize the prevalence and clinical features of the disease in Japan. Second, we reviewed the clinical presentation and treatment response of cases with inflammatory colorectal multiple polyps in miniature dachshunds, which were markedly over-represented in our study. MATERIALS AND METHODS Retrospective study of colorectal polyps in dogs:We reviewed the medical records of 33 dogs found to have colorectal polyps at the Veterinary Medical Center of the University of...

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Section: Discussionmentioning

confidence: 99%

A Retrospective Study of Inflammatory Colorectal Polyps in Miniature Dachshunds

Ohmi

Tsukamoto

Ohno

et al. 2012

The Journal of Veterinary Medical Science

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“…An inflammatory polyp is a common complication in patients with inflammatory bowel disease [2]. Most of the patients are asymptomatic, but in extreme cases it results in giant inflammatory polyps, which may present with abdominal pain, diarrhea, bleeding, fever, abdominal mass, obstruction and weight loss [3].…”

Section: Introductionmentioning

confidence: 99%

Protein-losing enteropathy, deep venous thrombosis and pulmonary embolism in a patient with generalized inflammatory polyposis in remission stage of ulcerative colitis

Kawaguchi

Mine

Kawana

et al. 2009

Clin J Gastroenterol

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We experienced a patient with severe protein-losing enteropathy and generalized inflammatory polyposis. In addition, this case was complicated by deep venous thrombosis and pulmonary embolism. Patients with inflammatory bowel disease are at increased risk for thromboembolic events, most commonly in the setting of active colitis. However, our patient was in the remission stage. We report the occurrence of deep venous thrombosis and pulmonary embolism as a complication of inflammatory polyposis and protein-losing enteropathy in the remission stage of ulcerative colitis.

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“…[1][2][3] Surgical intervention has often been indicated for such giant inflammatory lesions because of their tumor-like appearance and indefinite diagnosis. [3][4][5] In a recent study, however, magnifying colonoscopy was shown to distinguish such inflammatory polyposis from neoplastic lesions.…”

Section: Introductionmentioning

confidence: 99%

Localized giant inflammatory polyposis of the cecum associated with distal ulcerative colitis

Koinuma

Togashi

Konishi

et al. 2003

Journal of Gastroenterology

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This case report describes a 68-year-old man who presented with bronchiolitis obliterans organizing pneumonia (BOOP) and gastric carcinoma. During evaluation, including a colonoscopy, he was found to have distal colitis and a giant polypoid lesion in the cecum that was diagnosed as localized giant inflammatory polyposis (LGIP) by magnifying colonoscopy. The patient was treated over a period of 3 years without surgery, and the LGIP was reduced in size during the follow-up period. Magnifying observation was useful to distinguish LGIP from a neoplastic lesion.

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Pseudopolyposis in Ulcerative Colitis

Cited by 64 publications

References 22 publications

A Retrospective Study of Inflammatory Colorectal Polyps in Miniature Dachshunds

A Retrospective Study of Inflammatory Colorectal Polyps in Miniature Dachshunds

Protein-losing enteropathy, deep venous thrombosis and pulmonary embolism in a patient with generalized inflammatory polyposis in remission stage of ulcerative colitis

Localized giant inflammatory polyposis of the cecum associated with distal ulcerative colitis

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