Pseudonormal and restrictive filling patterns predict left ventricular dilation and cardiac death after a first myocardial infarction: a serial color M-mode doppler echocardiographic study

Moller, J.E; Søndergaard, E.; Poulsen, Sh.; Egstrup, Kenneth

doi:10.1016/s1062-1458(01)00250-1

Cited by 39 publications

(67 citation statements)

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“…However, data are mixed and there are some controversies regarding the predictive role of DT. Nijland and Møller found restrictive filling pattern predictive of cardiac death after acute myocardial infarction, when defining RF as a combination of DT and E/A ratio and colour M-mode flow velocity, respectively [26,32]. In a retrospective study of patients with idiopathic dilated cardiomyopathy, Rihal showed that systolic indices were stronger predictors of survival, though DT b 130 ms had an additive prognostic role when analysing subgroups with EF ≤ 25% [21].…”

Section: Discussionmentioning

confidence: 99%

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Prognostic importance of a short deceleration time in symptomatic congestive heart failure☆

Akkan

Kjærgaard

Møller

et al. 2008

European J of Heart Fail

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Aims: A restrictive transmitral filling (RF) pattern predicts increased mortality in heart failure (HF) with reduced left ventricular (LV) systolic function. We performed a combined evaluation of LV function and RF for prognosis in patients with HF with and without systolic dysfunction. Methods and results: Doppler echocardiography was performed in 972 patients with symptomatic HF. RF was considered present when deceleration time (DT) was ≤140 ms and non-RF when N 140 ms. A DT N 240 ms was defined as delayed relaxation. During a median of 51 months the unadjusted all-cause mortality rates were significantly increased among patients with RF vs. the non-RF group (1-and 4-year mortality was 25% and 54% vs. 17% and 43%). In a multivariable model, RF was a significant predictor of all-cause mortality (hazard ratio (HR) = 2.0, 95% confidence interval (CI):1.5-2.6) whereas delayed relaxation was without prognostic importance (HR = 0.9, CI:0.5-1.6). Repeating the multivariable model in subgroups of wall motion index (WMI) showed that RF was a strong predictor of mortality independent of WMI. For patients with LVEF of at least 50%, HR for RF was 2.0 (CI:1.1-3.4; p = 0.02) and interaction between LVEF and RF was not significant. Conclusion: In a heterogeneous population hospitalised for symptomatic HF a restrictive transmitral filling pattern, defined as shortened deceleration time, during hospitalisation is an ominous prognostic sign independent of LV systolic function.

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Section: Discussionmentioning

confidence: 99%

“…Cardiac cycles with fusion of early and late velocities or with nonlinear deceleration slope were excluded. RF was considered when deceleration time was ≤140 ms and non-RF when N 140 ms [25,26]. A filling pattern of delayed relaxation was considered if DT was N240 ms.…”

Section: Echocardiography and Data Analysismentioning

confidence: 99%

Prognostic importance of a short deceleration time in symptomatic congestive heart failure☆

Akkan

Kjærgaard

Møller

et al. 2008

European J of Heart Fail

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“…Infarct size was a determinant of slowing v p . In a serial echocardiographic study in patients after a first myocardial infarction, Moller et al [68] concluded that pseudo-normal or restrictive filling patterns, detected using colour M-mode Doppler, are related to progressive left ventricular dilation and predict cardiac death.…”

Section: Discussionmentioning

confidence: 99%

Diastolic Filling and Pressure Imaging: Taking Advantage of the Information in a Colour M-mode Doppler Image

Mey

Sutter

Vierendeels

et al. 2001

European Journal of Echocardiography

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The ability to derive non-invasively information on left ventricular diastolic function on one hand and pressure gradients on the other hand, makes Doppler ultrasound a very attractive tool in clinical practice. However, the limitations of the standard Doppler approaches in differentiating between normal and pseudonormal filling patterns, together with the limitations of the simplified Bernoulli equation for assessing pressure gradients, are well described. In this manuscript the role of colour M-mode Doppler echocardiography as a tool that can overcome these limitations is discussed. Relevant key concepts of the haemodynamics of left ventricular filling and its relationship with colour M-mode Doppler echocardiography are introduced.

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“…Echocardiographic indices of elevated left ventricular (LV) filling pressures are associated with adverse remodeling, increased incidence of heart failure and worse survival following acute myocardial infarction (AMI) [1][2][3][4]. Doppler tissue imaging of mitral annulus velocity reflects the rate of change in LV long-axis dimension and volume, thus impaired relaxation results in a reduced early mitral annulus velocity (e').…”

Section: Introductionmentioning

confidence: 99%

Association between time to reperfusion and echocardiography assessed left ventricular filling pressure in patients with first ST-segment elevation myocardial infarction undergoing primary coronary intervention

et al. 2014

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Background: Diastolic dysfunction and elevated left ventricular (LV) filling pressure following acute myocardial infarction are associated with adverse outcomes. Although time to reperfusion is a powerful prognostic marker following acute myocardial infarction, little is known about its impact on diastolic function and LV filling pressure. We hypothesized that delayed time to reperfusion will be associated with worse diastolic function. Methods: This study included 180 consecutive patients with first ST elevation myocardial infarction (STEMI) treated by primary percutaneous coronary intervention (PCI). They presented of chest pain within 24 h and underwent echocardiography within 3 days of primary PCI. Results: Median time to reperfusion, defined as the time from symptom onset to reperfusion at the end of primary PCI, was 185 min (interquartile range 120-660). Patients with reperfusion time > 185 min (n = 92) had a significantly higher E/septal e ' (13.3 ± 5.0 vs. 9.7 ± 2.3, p < 0.001) and E/lateral e' (9.8 ± 3.5 vs. 7.8 ± 2.2, p < 0.001) (Cardiol J 2014; 21, 4: 357-363)

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Pseudonormal and restrictive filling patterns predict left ventricular dilation and cardiac death after a first myocardial infarction: a serial color M-mode doppler echocardiographic study

Cited by 39 publications

References 0 publications

Prognostic importance of a short deceleration time in symptomatic congestive heart failure☆

Prognostic importance of a short deceleration time in symptomatic congestive heart failure☆

Diastolic Filling and Pressure Imaging: Taking Advantage of the Information in a Colour M-mode Doppler Image

Association between time to reperfusion and echocardiography assessed left ventricular filling pressure in patients with first ST-segment elevation myocardial infarction undergoing primary coronary intervention

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