Pseudomyxoma peritonei

Hinson, F. L.; Ambrose, N. S.

doi:10.1046/j.1365-2168.1998.00882.x

Cited by 157 publications

(155 citation statements)

References 62 publications

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“…On the other hand, most nonmucinous carcinomas presented with appendicitis or acute abdomen. The origin and histological classification of pseudomyxoma peritonei is controversial (16,17,(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39). Recent studies suggest that most cases of pseudomyxoma peritonei are caused by appendiceal mucinous tumors (17,23).…”

Section: Discussionmentioning

confidence: 99%

Mucinous and Nonmucinous Appendiceal Adenocarcinomas: Different Clinicopathological Features but Similar Genetic Alterations

et al. 2002

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The genetic alterations of appendiceal carcinomas have not been reported in detail. We studied the clinicopathological factors and genetic alterations including microsatellite instability, p53 overexpression, and mutations of the K-ras proto-oncogene of 30 appendiceal adenocarcinomas, consisting of 23 mucinous and 7 nonmucinous carcinomas. Sixteen (70%) mucinous carcinomas presented with pseudomyxoma peritonei, but 6 of 7 (86%) nonmucinous carcinomas presented with appendicitis (P ‫؍‬ .002). All carcinomas were microsatellite stable, and p53 overexpression was present in only 1 of 30 (3%) carcinomas. K-ras mutation was present in 11 of 20 (55%) carcinomas, including 8 of 16 (50%) mucinous and 3 of 4 (75%) nonmucinous carcinomas. The mean survival of patients with mucinous carcinomas was 26 ؎ 19 months compared with 13 ؎ 9 months for patients with nonmucinous carcinomas (P ‫؍‬ .0002). Our findings suggest that mucinous and nonmucinous carcinomas of appendix have similar genetic alterations, but different clinical presentation and prognosis. KEY WORDS: Adenocarcinoma, Appendix, K-ras, Microsatellite instability, p53. Mod Pathol 2002;15(6):599 -605Appendiceal carcinoma is an uncommon malignancy of the gastrointestinal tract with a prevalence ranging from 0.2 to 0.3% of appendectomy specimens (1, 2). Most appendiceal carcinomas arise from an adenomatous polyp or serrated adenoma (3-5) and present clinically with pseudomyxoma peritonei. Most colorectal cancers develop from adenomatous polyps, and morphological and genetic progression in an adenoma-adenocarcinoma sequence and in hereditary colorectal cancer syndromes are well described (6 -9). The majority of colorectal cancers have truncating mutations or deletions of the adenomatous polyposis coli (APC) gene on chromosome 5q or mutations of the ␤-catenin gene. Point mutations of the K-ras protooncogene and mutations and/or deletions of the p53 gene on chromosome 17p are also common. In a second pathway to colorectal neoplasia, microsatellite instability (MSI; also termed DNA replication errors and ubiquitous somatic mutations) is caused by mutations in a nucleotide mismatch repair gene, including hMSH2, hMLH1, PMS1, PMS2, and GTBP (6 -9). MSI is characterized by additions and deletions of nucleotides in numerous repeated nucleotide sequences (microsatellites). MSI is frequent in the right-sided colon carcinomas and mucinous colorectal carcinomas (6 -9).The genetic alterations in appendiceal carcinoma have not been reported in detail. We therefore studied MSI, p53 overexpression, and K-ras mutations in appendiceal carcinomas and compared these genetic alterations with the clinicopathologic findings. MATERIALS AND METHODS Case MaterialA computer search of MD Anderson Cancer Center surgical pathology diagnoses from 1995 through 2000 was performed. Primary appendiceal carcinomas were identified using the World Health Organization classification of appendiceal carcinomas (10). There were 30 patients with primary appendiceal carcinomas and available paraffin-embedded bloc...

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Section: Discussionmentioning

confidence: 99%

Mucinous and Nonmucinous Appendiceal Adenocarcinomas: Different Clinicopathological Features but Similar Genetic Alterations

et al. 2002

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“…5 When the appendix is examined histologically, mucoceles, adenomas or carcinomas are found in nearly all cases. Simultanous disease in the ovary might be explained either on the basis of spread from the appendix to the ovary or on the basis of two independent primary disease processes.…”

Section: Discussionmentioning

confidence: 99%

“…5 Flow cytometric analysis of the histological specimen for DNA has been used as an indicator for some neoplasms. In recent published reports, DNA ploidy was suggested to be a marker of metastatic potential, however, it was not correlated with patient survival, disease-free interval or histological grade.…”

Section: Discussionmentioning

confidence: 99%

Pseudomyxoma peritonei: Role of cytoreduction and intraperitoneal chemotherapy

Choi

Lee

Lam

2004

Annals of the College of Surgeons of Hong Kong

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In the past, pseudomyxoma peritonei was considered as an incurable disease and often no active treatment was given. With the advent of cytoreductive surgery, including peritonectomy procedures and intraperitoneal chemotherapy, long-term survival of these patients is actually possible. A 61-year-old patient with adenocarcinoma of the appendix who presented with a clinical picture of pseudomyxoma peritonei is described in the present report. The patient achieved independent activity of daily living and improved quality of life after aggressive surgical approach and intraperitoneal chemotherapy.

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“…El pseudomixoma peritoneal es una entidad clínica rara que se caracteriza por la ocupación de la cavidad peritoneal por grandes colecciones de contenido mucinoso y ascitis que envuelve la superficie peritoneal 2 . Actualmente se describe mayoritariamente en asociación con tumores malignos bien diferenciados o de malignidad en el límite.…”

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Adenocarcinoma Mucinoso de Uraco y Pseudomixoma Peritoneal

Delgado

Márquez

Solís

et al. 2006

Actas Urológicas Españolas

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RESUMENADENOCARCINOMA MUCINOSO DE URACO Y PSEUDOMIXOMA PERITONEAL. MUCINOUS ADENOCARCINOMA OF THE URACHUS AND PERITONEAL PSEUDOMYXOMA. El adenocarcinoma de uraco es un tumor extremadamente raro, con una incidencia de 1/5.000.000 de habitantes, lo que representa menos del 0,001 de todos los tumores de vejiga.El pseudomixoma peritoneal es una neoplasia rara caracterizada por ascitis mucinosa que envuelve la superficie peritoneal y el omento. Usualmente está asociada con tumores mucinosos benignos o malignos del apéndice u ovario.En este trabajo, presentamos un caso de pseudomixoma peritoneal causado por un adenocarcinoma mucinoso de uraco.Palabras Clave. Adenocarcinoma Mucinoso. Uraco. Pseudomixoma Peritoneal. ABSTRACT AB MUCINOUS ADENOCARCINOMA OF THE URACHUS AND PERITONEAL PSEUDOMYXOMAThe adenocarcinoma of the urachus is very rare tumor, with an incidence of 1/5.000.000 inhabitants, represents less than 0,001 of all types of bladder cancer.Peritoneal pseudomixoma is a rare neoplasm characterized by mucinous acites that involvement the peritoneal surface and omentum. Usually is associated with benign o malignant mucinous tumor of the appendix or ovary.In this paper, we present a case of peritoneal pseudomixoma caused by a mucinous adenocarcinoma of the urachus.

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Pseudomyxoma peritonei

Cited by 157 publications

References 62 publications

Mucinous and Nonmucinous Appendiceal Adenocarcinomas: Different Clinicopathological Features but Similar Genetic Alterations

Mucinous and Nonmucinous Appendiceal Adenocarcinomas: Different Clinicopathological Features but Similar Genetic Alterations

Pseudomyxoma peritonei: Role of cytoreduction and intraperitoneal chemotherapy

Adenocarcinoma Mucinoso de Uraco y Pseudomixoma Peritoneal

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