Pseudomyogenic (Epithelioid sarcoma-like) hemangioendothelioma with bone invasion

Karakaşlı, Ahmet; Karaaslan, Ahmet; Erduran, Mehmet; Çapkın, Sercan; Tuna, Emine Burçin; Havıtçıoğlu, Hasan

doi:10.1016/j.jor.2014.06.019

Cited by 12 publications

(12 citation statements)

References 7 publications

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“…As for keratins, AE1/AE3 was focally but not diffusely positive in this case. AE1/AE3 was usually positive in cases of pseudomyogenic hemangioendothelioma reported so far [ 1 – 5 , 10 – 14 ]. Some documents mentioned that the immunostaining pattern is diffuse.…”

Section: Discussionmentioning

confidence: 99%

Pseudomyogenic hemangioendothelioma/epithelioid sarcoma-like hemangioendothelioma of the lower limb: report of a rare case

et al. 2015

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Pseudomyogenic hemangioendothelioma is an extremely rare soft tissue tumor, also named as epithelioid sarcoma-like hemangioendothelioma, which occurs more frequently in young adult males. It was originally recognized as a variant of epitheloid sarcoma, however it is now concluded as a distinctive, rarely metastasizing endothelial neoplasm. We present a case of pseudomyogenic hemangioendothelioma in the lower limb in a 49-year-old female who has a long course of disease and suffered from twice local recurrences and lymph node affection of the tumor. The mass was subcutaneous and the margins were ill-defined. Morphologically, the tumor cells show diversity, composed of large spindle cells and round cells, both with abundant eocinophilic cytoplasm, mimicking rhybdomyoplasts and epitheloid cells respectively. The tumor cells show diffuse strong expression of Factor VIII, Fli-1, INI-1, vimentin, MDM2, and CDK4, local expression of CD31, AE1/AE3, EMA and P63, and no expression of CD34, S-100, actin-sm, desmin, MyoD1, and HMB45. Based on these information, this case is diagnosed as pseudomyogenic hemangioendothelioma after ruling out the main differential diagnosises including epithelioid sarcoma, malignant peripheral nerve sheath tumor and rhabdomyosarcoma. From this case we suggest that pseudomyogenic hemangioendothelioma may be confused with a variety of soft tissue neoplasm histologically. The clinical feature of the case of a long course of disease with twice local recurrences and final lymph node involvement 10 years after excision of the primary tumor indicates a relative indolent behavior of this tumor.

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Section: Discussionmentioning

confidence: 99%

Pseudomyogenic hemangioendothelioma/epithelioid sarcoma-like hemangioendothelioma of the lower limb: report of a rare case

et al. 2015

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“…The main treatment for PHE remains surgical excision of the lesions, even when there are multiple lesions, and sometimes amputation is needed to control the disease (2,3,6,7,11,15). Related to the characteristic SERPINE1-FOSB fusion of PHE, IJzendoorn et al recently reported the durable, complete remission of a patient with advanced unresectable PHE treated with telatinib (16).…”

Section: Discussionmentioning

confidence: 99%

Pseudomyogenic hemangioendothelioma: a little-known tumor

Santos¹,

Carvalho²,

Gomes³

et al. 2018

Acta Dermatovenerologica Alpina Pannonica Et Adriatica

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“…Currently, there is little literature regarding ES-H of bone. Primary bone lesions may be aggressive, with cortical destruction and soft tissue invasion (Karakasli et al 2014 ; Xu et al 2012 ). ES-H in our study showed cortical destruction, marked cystic/necrotic component, and abnormally enhanced tumor tissue, which was suggestive of malignant vascular tumor of bone.…”

Section: Discussionmentioning

confidence: 99%

Differential CT and MR imaging diagnosis between low- and high-grade malignant vascular tumors of bone

Chen

et al. 2016

SpringerPlus

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ObjectiveTo investigate the CT and MR imaging findings and differential diagnosis of malignant vascular tumors of bone. Materials and methodsCT and MR imaging findings of 18 patients with histopathology-proven malignant vascular tumors of bone were examined. Assessed image features included age, sex, location, CT findings, and MR imaging appearances and dynamic contrast-enhanced MR imaging. ResultsThe study group comprised 18 cases, of which 7 were categorized as low-grade malignant vascular tumors (LMT), and 11 were categorized as high-grade malignant vascular tumors (HMT). Malignant vascular tumors of bone showed osteolytic lesions with heterogeneous signs and enhancement, and frequently associated with soft tissue masses and peritumorous edema. The mean age of patient was respectively 34.7 years in LMT with 3 patients younger than 20 and 49.9 years in HMT with 3 patients older than 60 years. The mean lesion diameter was 3.6 cm (range 2–7.2) in LMT with two lesions <3 cm and 7.1 cm (range 3–13) in HMT with 3 lesions greater than 10 cm. LMT showed multifocal (57.1 %) and well-defined (71.5 %) lesions with residual bone (57.1 %), peripheral sclerosis (85.7 %), and slightly hetergeneous enhancement (71.4 %), compared to those of HMT with 9.1, 45.5, 27.3, and 72.7 %, and 9.1 % respectively. Also, HMT appeared as expansive (54.5 %), ill-defined (54.5 %), macroscopic necrosis/cystic (81.8 %) or hemorrhagic (27.3 %) lesion with pathological fracture (27.3 %), and often presented with obviously hetergeneous enhancement (81.8 %), compared to those of LMT with 42.9, 28.6, 42.9, 0, 14.3 and 14.3 % respectively.ConclusionsThere are some differences in the imaging features between LMT and HMT, while unifocal/multifocal, expansive, ill-defined, necrosis/cystic, hemorrhagic features with age, lesion diameter, peripheral sclerosis, residual bone tissue, pathological fracture and slightly/obviously hetergeneous enhancement highly suggest their differential diagnosis.

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Pseudomyogenic (Epithelioid sarcoma-like) hemangioendothelioma with bone invasion

Abstract: To the best of our knowledge is the first case report of epithelioid sarcoma-like hemangioendothelioma with bone invasion.

Cited by 12 publications

References 7 publications

Pseudomyogenic hemangioendothelioma/epithelioid sarcoma-like hemangioendothelioma of the lower limb: report of a rare case

Pseudomyogenic hemangioendothelioma/epithelioid sarcoma-like hemangioendothelioma of the lower limb: report of a rare case

Pseudomyogenic hemangioendothelioma: a little-known tumor

Differential CT and MR imaging diagnosis between low- and high-grade malignant vascular tumors of bone

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