Pseudomonas cepacia infection in cystic fibrosis: An emerging problem

Isles, Alan; MacLusky, Ian; Corey, Mary; Gold, Ronald; Prober, Charles G.; Fleming, Peter D.; Levison, Henry

doi:10.1016/s0022-3476(84)80993-2

Cited by 776 publications

(583 citation statements)

References 14 publications

Supporting

Mentioning

565

Contrasting

Unclassified

Order By: Relevance

“…Burkholderia (formerly Pseudomonas) cepacia is a 1980-5 and was 3 5 and 3.3 per 100000 admissions on multidrug-resistant Gram-negative bacillus that can medical and surgical services, respectively; 31 % of all cause respiratory infections among hospitalized B. cepacia infections involved the lower respiratory patients, including those with cystic fibrosis [1][2][3][4][5][6][7]. The tract [8].…”

Section: Introduction Us Hospitals Increased Significantly During Thementioning

confidence: 99%

Burkholderia cepacia respiratory tract acquisition: epidemiology and molecular characterization of a large nosocomial outbreak

Pegues

Ford

et al. 1996

Epidemiol. Infect.

View full text Add to dashboard Cite

SUMMARYIn 1994 we investigated a large outbreak of Burkholderia (formerly Pseudomonas) cepacia respiratory tract acquisition. A case patient was defined as any patient with at least one sputum culture from which B. cepacia was isolated from 1 January to 31 December 1994. Seventy cases were identified. Most (40 [61 %]) occurred between 1 February and 31 March 1994; of these, 35 (86%) were mechanically ventilated patients, 30 of whom were in an intensive-care unit (ICU) when B. cepacia was first isolated. Compared with control patients who were mechanically ventilated in an ICU, these 30 case-patients were significantly more likely to have been ventilated for 2 or more days (30/30 v. 15/30; P < 0-001) or to have been intubated more than once (12/30 v. 2/30; OR = 9-3, 95 % CI 1P6-68-8; P = 0-002) before the first isolation of B. cepacia. By multivariate analysis, the 35 mechanically ventilated casepatients were significantly more likely to have received a nebulized medication (OR = 11 9, 95 % CI = 1-6-553 1; P < 0-001) and a cephalosporin antimicrobial (OR = 11 9, 95 % CI = 1-6-553 1) in the 10 days before the first isolation of B. cepacia, compared with B. cepacianegative control-patients matched by date and duration of most recent mechanical ventilation. Although B. cepacia was not cultured from medications or the hospital environment, all outbreak strains tested had an identical DNA restriction endonuclease digestion pattern by pulsed-field gel electrophoresis. Review of respiratory therapy procedures revealed opportunities for contamination of nebulizer reservoirs. This investigation suggests that careful adherence to standard procedures for administration of nebulized medications is essential to prevent nosocomial respiratory infections.

show abstract

Section: Introduction Us Hospitals Increased Significantly During Thementioning

confidence: 99%

Burkholderia cepacia respiratory tract acquisition: epidemiology and molecular characterization of a large nosocomial outbreak

Pegues

Ford

et al. 1996

Epidemiol. Infect.

View full text Add to dashboard Cite

show abstract

“…B. cepacia often colonizes the lungs of patients with cystic fibrosis (10) and has emerged as an important opportunistic pathogen in hospitalized and immunocompromised patients (1,7,12,19). Small hospital outbreaks are frequent and are usually due to a single contaminated source such as disinfectant (16), intravenous solutions (19), nebulizer solutions (9), mouthwash (5), and medical devices, including respiratorytherapy equipment (13,20).…”

mentioning

confidence: 99%

Outbreak of Burkholderia cepacia Bacteremia in a Pediatric Hospital Due to Contamination of Lipid Emulsion Stoppers

et al. 2004

View full text Add to dashboard Cite

show abstract

“…Bcc consists of 18 different genetically related Gram-negative, non-spore-forming species (2). Infection with Bcc leads to a spectrum of clinical manifestations, ranging from asymptomatic carriage in respiratory secretions to necrotizing pneumonia (1,3,4). Burkholderia cenocepacia isolates are frequently virulent, transmissible, and innately resistant to multiple drug classes (1,5).…”

Section: N the Cystic Fibrosis (Cf) Patient Population Infection Withmentioning

confidence: 99%

“…B. cenocepacia is perhaps best known as the most frequent cause of "cepacia syndrome," a necrotizing pneumonia with septicemia resulting in rapid clinical decline and, frequently, death (4). CF patients infected with B. cenocepacia who undergo lung transplant are also at greater risk of death during the early postoperative period (6,18,19).…”

Section: Commentarymentioning

confidence: 99%

Clinafloxacin for Treatment of Burkholderia cenocepacia Infection in a Cystic Fibrosis Patient

Balwan

Nicolau

Wungwattana

et al. 2016

Antimicrob Agents Chemother

View full text Add to dashboard Cite

show abstract

Pseudomonas cepacia infection in cystic fibrosis: An emerging problem

Cited by 776 publications

References 14 publications

Burkholderia cepacia respiratory tract acquisition: epidemiology and molecular characterization of a large nosocomial outbreak

Burkholderia cepacia respiratory tract acquisition: epidemiology and molecular characterization of a large nosocomial outbreak

Outbreak of Burkholderia cepacia Bacteremia in a Pediatric Hospital Due to Contamination of Lipid Emulsion Stoppers

Clinafloxacin for Treatment of Burkholderia cenocepacia Infection in a Cystic Fibrosis Patient

Contact Info

Product

Resources

About