Pseudomonas aeruginosa toxins

Rolsma, Stephanie; Frank, Dara W.; Barbieri, Joseph T.

doi:10.1016/b978-0-12-800188-2.00005-7

Cited by 6 publications

(7 citation statements)

References 197 publications

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Section: Small-molecule Antivirulence Agentsmentioning

confidence: 99%

“…Infection with P. aeruginosa is typically hospital-acquired in patients with underlying medical conditions or compromised immune systems . Listed as a serious health threat due to multidrug resistance (Table ), infections with P. aeruginosa cause pneumonia, urinary tract infections, septicemia, and surgical site infections. , Particularly notable is its propensity to cause pneumonia in patients with cystic fibrosis and those on ventilators . Of the approximately 50 000 cases of P. aeruginosa infections per year in the United States, 13% or 6700 are multidrug resistant, and some strains of this bacterium have been found to be resistant to all or nearly all antibiotics .…”

Section: Small-molecule Antivirulence Agentsmentioning

confidence: 99%

“…P. aeruginosa elaborates multiple virulence factors, including the toxin exotoxin A (ETA) (638 amino acids) that catalyzes the ADP-ribosylation of eukaryotic elongation factor 2 (eEF2). ETA is synthesized as a single polypeptide with an N-terminal receptor binding domain, a translocation domain, and a C-terminal ADP-ribosylstransferase domain . The toxin is cleaved by furin on the cell surface into its A and B subunits, which are linked by a disulfide bond.…”

Section: Small-molecule Antivirulence Agentsmentioning

confidence: 99%

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Chemical Strategies To Target Bacterial Virulence

2017

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Antibiotic resistance is a significant emerging health threat. Exacerbating this problem is the overprescription of antibiotics as well as a lack of development of new antibacterial agents. A paradigm shift toward the development of nonantibiotic agents that target the virulence factors of bacterial pathogens is one way to begin to address the issue of resistance. Of particular interest are compounds targeting bacterial AB toxins that have the potential to protect against toxin-induced pathology without harming healthy commensal microbial flora. Development of successful antitoxin agents would likely decrease the use of antibiotics, thereby reducing selective pressure that leads to antibiotic resistance mutations. In addition, antitoxin agents are not only promising for therapeutic applications, but also can be used as tools for the continued study of bacterial pathogenesis. In this review, we discuss the growing number of examples of chemical entities designed to target exotoxin virulence factors from important human bacterial pathogens.

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Section: Small-molecule Antivirulence Agentsmentioning

confidence: 99%

Section: Small-molecule Antivirulence Agentsmentioning

confidence: 99%

Section: Small-molecule Antivirulence Agentsmentioning

confidence: 99%

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Chemical Strategies To Target Bacterial Virulence

2017

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“…Pseudomonas aeruginosa has a high resistance to antibiotics and can utilize various mutation mechanisms as a reaction to alterations in the surrounding environment. All these factors make P. aeruginosa an excellent candidate for these studies due to its relevance in biomedical research and its ability to quickly adapt to changes in external conditions. − We aim to show in this work that UV-treated GaN surfaces can serve as programmable functional interfaces that contain living bacteria . With this in mind we show that changes in semiconductor surface properties can be programmed to change the P. aeruginosa behavior without killing it.…”

Section: Introductionmentioning

confidence: 99%

Interfacial Properties of Doped Semiconductor Materials Can Alter the Behavior of Pseudomonas aeruginosa Films

Gulyuk

LaJeunesse

Reddy

et al. 2019

ACS Appl. Electron. Mater.

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A simple treatment of UV light exposure can change the interfacial properties of variably doped GaN substrates. The changes in surface charge and chemistry after exposure to UV light were studied as way to alter the behavior of Pseudomonas aeruginosa films. The properties of GaN surfaces were characterized by atomic force microscopy, Kelvin probe force microscopy, and X-ray photoelectron spectroscopy. The Pseudomonas aeruginosa film responses were quantified by analyzing changes in the amount of catalase, reactive oxygen species, and intracellular Ca 2+ concentrations. The comprehensive analysis supports the notion that the response of P. aeruginosa biofilms can be controlled by the properties of the interface and the amount of time the film is in contact with it.

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“…P. aeruginosa becomes problematic for antimicrobial treatment because of its inherent resistance to many antibiotics, capability to rapidly acquire strong resistance to adverse external conditions, and ability to develop drug resistance using diverse mutations mechanisms. − It has been reported that P. aeruginosa is capable of forming tough and resilient biofilms on various substrates. ,, Furthermore, by transitioning from planktonic to biofilm form, P.…”

Section: Introductionmentioning

confidence: 99%

Characterization ofPseudomonas aeruginosaFilms on Different Inorganic Surfaces before and after UV Light Exposure

et al. 2018

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The changes of the surface properties of Au, GaN, and SiO after UV light irradiation were used to actively influence the process of formation of Pseudomonas aeruginosa films. The interfacial properties of the substrates were characterized by X-ray photoelectron spectroscopy and atomic force microscopy. The changes in the P. aeruginosa film properties were accessed by analyzing adhesion force maps and quantifying the intracellular Ca concentration. The collected analysis indicates that the alteration of the inorganic materials' surface chemistry can lead to differences in biofilm formation and variable response from P. aeruginosa cells.

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Pseudomonas aeruginosa toxins

Cited by 6 publications

References 197 publications

Chemical Strategies To Target Bacterial Virulence

Chemical Strategies To Target Bacterial Virulence

Interfacial Properties of Doped Semiconductor Materials Can Alter the Behavior of Pseudomonas aeruginosa Films

Characterization ofPseudomonas aeruginosaFilms on Different Inorganic Surfaces before and after UV Light Exposure

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