Pseudomonas aeruginosa infective endocarditis in patients who do not use intravenous drugs: Analysis of risk factors and treatment outcomes

Lin, Ting-I; Huang, Ya-Ling; Liu, Po-Yen; Chou, Chin-An; Chen, Yu-Shen; Chen, Yingyao; Hsieh, Kai‐Sheng; Chen, Yao-Shen

doi:10.1016/j.jmii.2014.08.019

Cited by 37 publications

(51 citation statements)

References 31 publications

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“…Brucella endocarditis generally involves aortic valve, 26 but in patients of the current study one had mitral valve and other had tricuspid valve involvement. Pseudomonas aeruginosa is a rare cause of infective endocarditis, 27 mostly occurs in intravenous drug abusers 28 . The single case of Pseudomonas aeruginosa endocarditis was noted in a female patient with a foreign body embedded in the right ventricular endocardium after incomplete removal of a temporary pacemaker.…”

Section: Discussionmentioning

confidence: 99%

Clinical – microbiological characterization and risk factors of mortality in infective endocarditis from a tertiary care academic hospital in Southern India

Subbaraju

Rai

Morakhia

et al. 2018

Indian Heart Journal

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Section: Discussionmentioning

confidence: 99%

Clinical – microbiological characterization and risk factors of mortality in infective endocarditis from a tertiary care academic hospital in Southern India

Subbaraju

Rai

Morakhia

et al. 2018

Indian Heart Journal

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“…8 However, in many cases, especially with the emergence of multidrug-resistant strains, 53,54 these methods are not efficient, and therefore, additional means of disinfecting wounds are clearly needed. Furthermore, P. aeruginosa and S. epidermidis can cause deep infections in many tissue sites, including joints, 10,55 lung, heart, 56 liver, 57 and implants. 10 To address these problems, we recently proposed to use non-thermal, high-voltage PEF technology, previously found to be effective for wounds and surgical mesh disinfection.…”

Section: Clinical Relevancementioning

confidence: 99%

Selective Inactivation ofPseudomonas aeruginosaandStaphylococcus epidermidiswith Pulsed Electric Fields and Antibiotics

Rubin

Usta

Schloss

et al. 2019

Advances in Wound Care

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Increasing numbers of multidrug-resistant bacteria make many antibiotics ineffective; therefore, new approaches to combat microbial infections are needed. In addition, antibiotics are not selective-they kill pathogenic organisms as well as organisms that could positively contribute to wound healing (bio flora). Approach: Here we report on selective inactivation of Pseudomonas aeruginosa and Staphylococcus epidermidis, potential pathogens involved in wound infections with pulsed electric fields (PEFs) and antibiotics (mix of penicillin, streptomycin, and nystatin). Results: Using a Taguchi experimental design in vitro, we found that, under similar electric field strengths, the pulse duration is the most important parameter for P. aeruginosa inactivation, followed by the number of pulses and pulse frequency. P. aeruginosa, a potential severe pathogen, is more sensitive than the less pathogenic S. epidermidis to PEF (alone or in combination with antibiotics). Applying 200 pulses with a duration of 60 ls at 2.8 Hz, the minimum electric fields of 308.8-28.3 and 378.4-12.9 V/mm were required to inactive P. aeruginosa and S. epidermidis, respectively. Addition of antibiotics reduced the threshold for minimum electric fields required to inactivate the bacteria. Innovation: This study provides essential information, such as critical electric field parameters for bacteria inactivation, required for developing in vivo treatment and clinical protocols for using PEF for wound healing. Conclusion: A combination of PEFs with antibiotics reduces the electric field threshold required for bacteria disinfection. Such an approach simplifies devices required to disinfect large areas of infected wounds.

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“…P. aeruginosa is also known to cause a wide variety of other infections, encompassing all organs of the human body, including soft tissue infection in burns, open wounds and postsurgery; urinary tract infection associated with the use of urinary catheter; foot infection in diabetics and individuals with impaired microvascular circulation; ear infection, especially otitis externa and chronic suppurative otitis media associated with tissue injury and water blockage; and keratitis associated with extended contact lens wear and contaminated contact lens [ 8 ]. Other rarer but serious infections include endocarditis occurring in patients with or without injection drug use [ 9 , 10 ]; and meningitis associated with penetrating trauma to the head, placement of a CNS shunt (such as a ventriculoperitoneal (VP) shunt), or post-neurosurgical procedures [ 10 , 11 ]. Poor antibiotic stewardship in the past few decades has led to emergence and spread of multidrug-resistant strains.…”

Section: Introductionmentioning

confidence: 99%

An Organ System-Based Synopsis ofPseudomonas aeruginosaVirulence

et al. 2021

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Driven in part by its metabolic versatility, high intrinsic antibiotic resistance, and a large repertoire of virulence factors, Pseudomonas aeruginosa is expertly adapted to thrive in a wide variety of environments, and in the process, making it a notorious opportunistic pathogen. Apart from the extensively studied chronic infection in the lungs of people with cystic fibrosis (CF), P. aeruginosa also causes multiple serious infections encompassing essentially all organs of the human body, among others, lung infection in patients with chronic obstructive pulmonary disease, primary ciliary dyskinesia and ventilator-associated pneumonia; bacteremia and sepsis; soft tissue infection in burns, open wounds and postsurgery patients; urinary tract infection; diabetic foot ulcers; chronic suppurative otitis media and otitis externa; and keratitis associated with extended contact lens use. Although well characterized in the context of CF, pathogenic processes mediated by various P. aeruginosa virulence factors in other organ systems remain poorly understood. In this review, we use an organ system-based approach to provide a synopsis of disease mechanisms exerted by P. aeruginosa virulence determinants that contribute to its success as a versatile pathogen.

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Pseudomonas aeruginosa infective endocarditis in patients who do not use intravenous drugs: Analysis of risk factors and treatment outcomes

Abstract: P. aeruginosa endocarditis has substantial morbidity and mortality. It is characterized by easy relapse and is highly associated with prosthetic devices.

Cited by 37 publications

References 31 publications

Clinical – microbiological characterization and risk factors of mortality in infective endocarditis from a tertiary care academic hospital in Southern India

Clinical – microbiological characterization and risk factors of mortality in infective endocarditis from a tertiary care academic hospital in Southern India

Selective Inactivation ofPseudomonas aeruginosaandStaphylococcus epidermidiswith Pulsed Electric Fields and Antibiotics

An Organ System-Based Synopsis ofPseudomonas aeruginosaVirulence

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