Pseudomonas aeruginosa infections in a neonatal intensive care unit

Zafar, Abdul B.; Sylvester, Linda K; Beidas, Sary

doi:10.1067/mic.2002.121153

Cited by 19 publications

(11 citation statements)

References 41 publications

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“…[12][13][14][15] These measures frequently involve cohort isolation, meticulous hand hygiene 6 and barrier protection of the care team and parents by use of gloves and gowns. Pharmacologic agents have been used with some success, particularly with intranasal mupirocin for methicillin resistant Staphylococcus aureus.…”

Section: Discussionmentioning

confidence: 99%

Sustained reductions in neonatal nosocomial infection rates following a comprehensive infection control intervention

et al. 2005

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Objective: Nosocomial infections (NI) are a frequent and important cause of morbidity and mortality in newborn infants who receive intensive care. We sought to determine if comprehensive infection control (CIC) measures decrease rates in a large neonatal intensive care nursery.Methods: Single center interventional study. The CIC intervention consisted of increasing nursing and physician education and awareness of infection rates, establishing common improvement goals, training in hand and environment care, and implementing a specialty nursing team for central venous and arterial catheter care. Demographic and microbiology information for all infants admitted to the NICU from Results: Baseline infection rate was 8.5 per 1000 hospital days. The NI rate fell 26% (P ¼ 0.002) from baseline in the first year and 29% (P<0.001) in the second and third years after the CIC intervention. The reduction in total NI was due mostly to a 46% fall in coagulase-negative Staphylococcus infection rate (P<0.001); however, rates of all other organisms also fell by 21% (P ¼ 0.05).Conclusions: CIC measures can reduce bacterial and fungal NI rates. This effect has been sustained for 3 years following the intervention.

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Section: Discussionmentioning

confidence: 99%

Sustained reductions in neonatal nosocomial infection rates following a comprehensive infection control intervention

et al. 2005

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“…Pseudomonas aeruginosa is one of the main organisms responsible for drug-resistant health care-associated infections [1][2][3] . Its ability to survive and replicate in hospital in a wide range of ecological niches, sometimes hostile to other microorganisms, may create tenacious environmental reservoirs, such as faucets, tap water, sinks, respiratory-therapy equipment and even detergents and disinfectants [4,5] .…”

Section: Introductionmentioning

confidence: 99%

“…Well known as a multiresistant organism, it is posing new therapeutic and public health challenges because of the emergence and widespread dissemination of strains producing metallo-β-lactamases (MBL). Indeed, these enzymes can confer resistance to all β-lactams except monobactams and are not susceptible to the clinically available β-lactamase inhibitors [3,6] . Several types of these enzymes have been detected; namely, IMP, VIM, SPM, GIM and SIM, mostly in P aeruginosa and other Gram-negative nonfermenters [7] .…”

Section: Introductionmentioning

confidence: 99%

Nosocomial colonization due to imipenem-resistant Pseudomonas aeruginosa epidemiologically linked to breast milk feeding in a neonatal intensive care unit

et al. 2008

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Aim: We describe a one-year investigation of colonization by imipenemresistant, metallo-β-lactamase (MBL) producing Pseudomonas aeruginosa in a neonatal intensive care unit (NICU) of the University Hospital of Palermo, Italy. Methods: A prospective epidemiological investigation was conducted in the period 2003 January to 2004 January. Rectal swabs were collected twice a week from all neonates throughout their NICU stay. MBL production by imipenem-resistant strains of P aeruginosa was detected by phenotypic and molecular methods. Pulsed field gel electrophoresis (PFGE) was carried out on all isolates of P aeruginosa. The association between risk factors and colonization by imipenem-resistant, imipenem-susceptible P aeruginosa isolates and other multidrug-resistant Gram negative (MDRGN) organisms was analyzed for variables present at admission and during the NICU stay. Data analysis was carried out by the Cox proportional hazards regression model. Results: Twentytwo of 210 neonates were colonized with imipenem-resistant, MBL-producing P aeruginosa isolates and 14 by imipenem-susceptible P aeruginosa isolates. A single pulsotype, named A, was shared by all imipenem-resistant isolates. Colonization by P aeruginosa of pulsotype A was positively correlated with breast milk feeding and administration of ampicillin-sulbactam, and inversely correlated with exclusive feeding by formula. In the Cox proportional hazards regression model, birthweight of more than 2500 g and breast milk feeding were independently associated with an increased risk of colonization by MBLproducing P aeruginosa. Conclusion: The results strongly support an association between colonization by a well-defined imipenem-resistant, MBL producing P aeruginosa strain and breast milk feeding. Such a study may highlight the need for implementation of strategies to prevent expressed breast milk from becoming a vehicle of health care-associated infections. Key wordsneonatal intensive care unit; Pseudomonas aeruginosa; metallo-β-lactamase; breast milk 4 Correspondence to Dr Caterina MAMMINA, MD. Phn +39-091-655-3623.

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“…Some strains can produce biofi lm containing a mucoid polysaccharide called alginate which makes them less suscep ble to an microbials. Furthermore, Exotoxin A and Exoenzyme S are the products produced by pseudomonas which are responsible for the development of sepsis syndrome by the organism 9 . The organism also produce plasmid associated beta lactamases which render the organism mul drug resistant.…”

Section: Discussionmentioning

confidence: 99%

Neonatal Empyema Thoracis

Mazumdar

Sen

2014

J. Nepal Paedtr. Soc.

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Empyema thoracis, is a rare cause of respiratory distress in neonates. Only a few cases of neonatal empyema thoracis are described in medical literature. Empyema thoracis is not a well known entity in the neonates. It is fulminant with rapid progression with a high mortality. Compounding the problem is its uncertain etiopathogenesis and lack of definite treatment guidelines. We shall describe one case of neonatal empyema in a newborn aged five days caused by Pseudomonas aeruginosa. The neonate died subsequently.

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Pseudomonas aeruginosa infections in a neonatal intensive care unit

Cited by 19 publications

References 41 publications

Sustained reductions in neonatal nosocomial infection rates following a comprehensive infection control intervention

Sustained reductions in neonatal nosocomial infection rates following a comprehensive infection control intervention

Nosocomial colonization due to imipenem-resistant Pseudomonas aeruginosa epidemiologically linked to breast milk feeding in a neonatal intensive care unit

Neonatal Empyema Thoracis

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