Pseudomonas aeruginosa en dermatologie

Morand, A.; Morand, J.-J.

doi:10.1016/j.annder.2017.06.015

Cited by 24 publications

(22 citation statements)

References 24 publications

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“…seudomonas aeruginosa is a Gram-negative bacterium that causes infectious diseases including urinary and gastrointestinal tract infections, dermatitis, and bacteremia [1][2][3] . Lung infections by P. aeruginosa is very common in hospitals and is life threatening to patients with complicated conditions at a very high mortality 4 .…”

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confidence: 99%

Co-delivery of resolvin D1 and antibiotics with nanovesicles to lungs resolves inflammation and clears bacteria in mice

et al. 2020

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Resolution is an active process that protects the host damage from inflammation responses induced by infections. Simultaneously resolving inflammation and eliminating pathogens may be effective to treat infectious diseases, but it is required to deliver therapeutics to infectious sites. Here, we proposed a strategy to incorporate RvD1 and an antibiotic (ceftazidime) in human neutrophil-membrane derived nanovesicles that can specifically target inflamed vasculature for treatment of lung infection caused by P. aeruginosa. Using the nitrogen cavitation method, we generated liposome-like nanovesicles from human neutrophil membrane. The results showed that nanovesicles loaded with RvD1 decreased cytokine levels and neutrophil lung infiltration, thus shortening the resolution intervals of lung inflammation. When RvD1 and ceftazidime were co-loaded in nanovesicles, they alleviated both inflammation and bacterial growth in the mouse lung. The studies reveal a new strategy to treat infectious diseases by designing nanoparticles to simultanesouly target host inflammatory pathways and pathogens.

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confidence: 99%

Co-delivery of resolvin D1 and antibiotics with nanovesicles to lungs resolves inflammation and clears bacteria in mice

et al. 2020

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“…aeruginosa infection is ecthyma gangrenosum 20 . This rare and fulminant infection associated with pseudomonal sepsis is characterized by round erythematous macules and patches that develop into central pustules with surrounding erythema, then haemorrhagic vesicles and eventually a gangrenous ulcer with a black eschar 9 . It is very rare in the DFI and usually occurs in the extremities of immune‐suppressed patients, 20 including in children 9 …”

Section: Discussionmentioning

confidence: 99%

“…Only HCWs with at least 1 year of 100% daily experience on the DFI team were allowed to participate. HCWs could use their own subjective definition of visual clues (eg greenish colour 8 ) (Figure 1) or olfactory clues (eg grape juice–like smell 9 ). Importantly, to ensure that HCW only expressed their own opinion, we solicited their responses individually.…”

Section: Methodsmentioning

confidence: 99%

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How good are clinicians in predicting the presence ofPseudomonasspp. in diabetic foot infections? A prospective clinical evaluation

Uçkay

Holy

Schöni

et al. 2021

Endocrino Diabet & Metabol

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Introduction The most frequently prescribed empirical antibiotic agents for mild and moderate diabetic foot infections (DFIs) are amino‐penicillins and second‐generation cephalosporins that do not cover Pseudomonas spp. Many clinicians believe they can predict the involvement of Pseudomonas in a DFI by visual and/or olfactory clues, but no data support this assertion. Methods In this prospective observational study, we separately asked 13 experienced (median 11 years) healthcare workers whether they thought the Pseudomonas spp. would be implicated in the DFI. Their predictions were compared with the results of cultures of deep/intraoperative specimens and/or the clinical remission of DFI achieved with antibiotic agents that did not cover Pseudomonas. Results Among 221 DFI episodes in 88 individual patients, intraoperative tissue cultures grew Pseudomonas in 22 cases (10%, including six bone samples). The presence of Pseudomonas was correctly predicted with a sensitivity of 0.32, specificity of 0.84, positive predictive value of 0.18 and negative predictive value 0.92. Despite two feedbacks of the interim results and a 2‐year period, the clinicians' predictive performance did not improve. Conclusion The combined visual and olfactory performance of experienced clinicians in predicting the presence of Pseudomonas in a DFI was moderate, with better specificity than sensitivity, and did not improve over time. Further investigations are needed to determine whether clinicians should use a negative prediction of the presence of Pseudomonas in a DFI, especially in settings with a high prevalence of pseudomonal DFIs.

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“…Pseudomonas Aeruginosa can cause toe web infection, usually complicating other skin conditions such as Allergic contact dermatitis, primary or secondary hyperhidrosis, or superimpose fungal infections such as Tinea Pedis. Ecthyma gangrenosum is a serious sequela of untreated infection and can even lead to fatal consequences (Morand & Morand, ). Pseudomonas Aeruginosa has a unique mechanism of action and virulence factors helping it resist antibiotic treatment.…”

Section: Discussionmentioning

confidence: 99%

Acetic acid treatment for toe web infection caused by Pseudomonas Aeruginosa combined with fungal infection: A case series of ten patients

Rozenblat

Last

Fisher

et al. 2019

Dermatologic Therapy

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Gram‐negative bacterial toe web infection (GNBTWI) caused by Pseudomonas Aeruginosa combined with fungal infection has variety of treatments. However, these treatments have been poorly described in the literature. Our retrospective study describes patients that had been treated in our medical center with acetic acid combined with local antifungal treatment, to evaluate evidences for the appropriateness of this treatment. Ten patients with evidence of GNBTWI caused by Pseudomonas Aeruginosa combined with local fungal infection which have been treated with acetic acid in Emek Medical Center were identified. Eight patients (80%) had a complete response while two patients (20%) showed only a partial response. Side effects were minimal and included temporary stinging sensation. Acetic acid is a relatively cheap ingredient with minimal side effect profile and highly effective outcomes as a treatment for GNBTWI caused by Pseudomonas Aeruginosa and should be considered as an adjuvant treatment.

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Pseudomonas aeruginosa en dermatologie

Cited by 24 publications

References 24 publications

Co-delivery of resolvin D1 and antibiotics with nanovesicles to lungs resolves inflammation and clears bacteria in mice

Co-delivery of resolvin D1 and antibiotics with nanovesicles to lungs resolves inflammation and clears bacteria in mice

How good are clinicians in predicting the presence ofPseudomonasspp. in diabetic foot infections? A prospective clinical evaluation

Acetic acid treatment for toe web infection caused by Pseudomonas Aeruginosa combined with fungal infection: A case series of ten patients

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