Pseudomonas aeruginosa cross-infection among patients with cystic fibrosis during a winter camp

Ojeniyi, B.; Frederiksen, Birgitte; Høiby, Niels

doi:10.1002/(sici)1099-0496(200003)29:3<177::aid-ppul4>3.0.co;2-u

Cited by 98 publications

(74 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This indicates that the biological conditions in the CF respiratory tract allow P. aeruginosa strains from a wide range of ecological origins to be pathogenic. Thus, as previously suggested, CF patients should be isolated when they are hospitalized, and meetings of CF patients, for example in cure centres or holiday camps, may not be advisable (Kosorok et al, 1998;Ojeniyi et al, 2000;Tummler et al, 1991).…”

Section: Discussionmentioning

confidence: 99%

“…The emergence of the RAPD group RC may have resulted from a combination of many factors. Although the CF patients included in this study were from 19 different centres, cross-colonization by strains of this RAPD group cannot be excluded, because some of them may have previously been hospitalized together (Hoogkamp-Korstanje et al, 1995;Kosorok et al, 1998;Ojeniyi et al, 2000). However, RAPD group RC, which contained 38 % of all CF isolates, also contained 30 % of the isolates from plants (Table 2).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Genetic features of Pseudomonas aeruginosa isolates from cystic fibrosis patients compared with those of isolates from other origins

Lanotte¹,

Watt²,

Mereghetti³

et al. 2004

Journal of Medical Microbiology

125

View full text Add to dashboard Cite

In order to improve our understanding of the colonization of the pulmonary tract of cystic fibrosis (CF) patients by Pseudomonas aeruginosa, 162 isolates from five different ecological origins were studied. The genetic features of each isolate were determined by random amplification of polymorphic DNA (RAPD) and by searching for eight virulence genes (six known virulence genes, algD, lasB, toxA, plcH, plcN and exoS, and two genes encoding putative neuraminidases, nan1 and nan2). Five RAPD groups were identified. Most of the CF isolates were distributed equally in three of these groups (RA, RB and RC). The CF isolates in RB were related to isolates from a wide variety of origins. The CF isolates in RA were related to a population composed of 65 % of the non-CF isolates from pulmonary tract infections. RC was mainly composed of CF isolates that were related to 30 % of isolates from plants. All genes except exoS and nan1 were present in all isolates. The exoS and nan1 virulence factor genes were most prevalent in CF isolates. exoS, which encodes exoenzyme S, was present in 94 % of CF isolates but also in 80 % of non-CF isolates from pulmonary tract infections. nan1, which encodes a putative neuraminidase, was found in 82 . 5 % of the isolates from group RC, which was composed largely of CF isolates. In conclusion, three major genogroups of P. aeruginosa isolates, each of which exhibits peculiar genetic features, are able to colonize CF patients. This may have different consequences on the outcome of pulmonary disease.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Genetic features of Pseudomonas aeruginosa isolates from cystic fibrosis patients compared with those of isolates from other origins

Lanotte¹,

Watt²,

Mereghetti³

et al. 2004

Journal of Medical Microbiology

125

View full text Add to dashboard Cite

show abstract

“…Given the strong evidence of person-to-person spread of CF pathogens in CF camps and educational retreats, people with CF should not participate in these settings with others with CF. 151,[455][456][457] However, people with CF are encouraged to attend camps and retreats with individuals without CF.…”

Section: Ivi1 Camps and Educational Retreatsmentioning

confidence: 99%

Infection Prevention and Control Guideline for Cystic Fibrosis: 2013 Update

Saiman

Siegel

LiPuma

et al. 2014

Infect. Control Hosp. Epidemiol.

344

382

View full text Add to dashboard Cite

The 2013 Infection Prevention and Control (IP&C) Guideline for Cystic Fibrosis (CF) was commissioned by the CF Foundation as an update of the 2003 Infection Control Guideline for CF. During the past decade, new knowledge and new challenges provided the following rationale to develop updated IP&C strategies for this unique population:1. The need to integrate relevant recommendations from evidence-based guidelines published since 2003 into IP&C practices for CF. These included guidelines from the Centers for Disease Control and Prevention (CDC)/Healthcare Infection Control Practices Advisory Committee (HICPAC), the World Health Organization (WHO), and key professional societies, including the Infectious Diseases Society of America (IDSA) and the Society for Healthcare Epidemiology of America (SHEA). During the past decade, new evidence has led to a renewed emphasis on source containment of potential pathogens and the role played by the contaminated healthcare environment in the transmission of infectious agents. Furthermore, an increased understanding of the importance of the application of implementation science, monitoring adherence, and feedback principles has been shown to increase the effectiveness of IP&C guideline recommendations.2. Experience with emerging pathogens in the non-CF population has expanded our understanding of droplet transmission of respiratory pathogens and can inform IP&C strategies for CF. These pathogens include severe acute respiratory syndrome coronavirus and the 2009 influenza A H1N1. Lessons learned about preventing transmission of methicillin-resistant Staphylococcus aureus (MRSA) and multidrug-resistant gram-negative pathogens in non-CF patient populations also can inform IP&C strategies for CF.

show abstract

“…Although we believe that it is the responsibility of the rehabilitation site to demonstrate lack of transmission, we have recently started to also closely monitor our patients before and after rehabilitation, but in the future evaluation of respiratory pathogens by clonality is required to really assess the cross-infection risk. In the so called summer camps, where patients were encouraged to have close psychosocial contacts and where no structural measures for hygiene were implemented or controlled [3][4][5][6], but also in rehabilitation programs when the appropriate measures were not undertaken to prevent clonal spread of cystic fibrosis bacteria [19,20], person to person transmission of bacteria have been demonstrated. Therefore unequivocally the rehabilitation sites have to demonstrate that they are safe from a hygiene aspect.…”

Section: Discussionmentioning

confidence: 99%

“…These were holiday-like rehabilitation efforts for cystic fibrosis patients, which were not infection controlled and cohorted considering pulmonary pathogens. In these camps a significant risk of microbial cross infection between patients was demonstrated [2][3][4][5][6][7][8]. Nevertheless, rehabilitation programs in cystic fibrosis have a long standing tradition in some European countries [9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Rehabilitation Programs for Cystic Fibrosis - View from a CF Center

Griese¹,

Busch²,

Caroli³

et al. 2010

TORMJ

View full text Add to dashboard Cite

Abstract:Background: Rehabilitation programs are comprehensive interventions which effectively improve the health status and reduce costs in chronic respiratory illnesses. Because patients with cystic fibrosis have been discouraged to participate for concerns of microbial cross infection, the efficacy of systematic rehabilitation is unknown for this group. Methods:We retrospectively studied 142 cystic fibrosis patients aged 2-46 years who participated in rehabilitation programs taking place in Germany/Switzerland and in Israel, focusing on changes in lung function and weight.Results: During 172 stays in 97 patients in Israel and 68 stays in 45 patients rehabilitating in Germany/Switzerland, overall lung function and weight improved. Outcome did not differ between Israel and German/Swiss sites. Interestingly, lung function improved during the initial phase of the stay, whereas weight gain was sustained throughout. The study uncovered gaps in reporting sufficient individual outcome information back to the admitting centre.Conclusions: Rehabilitation programs specified for cystic fibrosis patients need to be assessed prospectively to optimize treatment of this life limiting condition.

show abstract

Pseudomonas aeruginosa cross-infection among patients with cystic fibrosis during a winter camp

Cited by 98 publications

References 20 publications

Genetic features of Pseudomonas aeruginosa isolates from cystic fibrosis patients compared with those of isolates from other origins

Genetic features of Pseudomonas aeruginosa isolates from cystic fibrosis patients compared with those of isolates from other origins

Infection Prevention and Control Guideline for Cystic Fibrosis: 2013 Update

Rehabilitation Programs for Cystic Fibrosis - View from a CF Center

Contact Info

Product

Resources

About