Pseudomonas aeruginosa and Bronchiectasis

Soyza, Anthony De; Winstanley, Craig

doi:10.1007/978-3-319-61452-6_12

Cited by 2 publications

(2 citation statements)

References 154 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…After the identification of P. aeruginosa growing as biofilms in the lungs of these patients, this chronic lung infection turned into the icon of biofilm-associated infections and P. aeruginosa became the model species for biofilm infection studies [52]. P. aeruginosa also causes persistent infections in non-cystic fibrosis respiratory diseases, such as bronchiectasis and chronic obstructive pulmonary disease [53,54], and in chronic rhinosinusitis [55]. The role of P. aeruginosa in urinary tract infections is minor compared to the diseases described above.…”

Section: Introductionmentioning

confidence: 99%

Current Status of In Vitro Models and Assays for Susceptibility Testing for Wound Biofilm Infections

Bahamondez-Canas

Heersema

2019

Biomedicines

View full text Add to dashboard Cite

Biofilm infections have gained recognition as an important therapeutic challenge in the last several decades due to their relationship with the chronicity of infectious diseases. Studies of novel therapeutic treatments targeting infections require the development and use of models to mimic the formation and characteristics of biofilms within host tissues. Due to the diversity of reported in vitro models and lack of consensus, this review aims to provide a summary of in vitro models currently used in research. In particular, we review the various reported in vitro models of Pseudomonas aeruginosa biofilms due to its high clinical impact in chronic wounds and in other chronic infections. We assess advances in in vitro models that incorporate relevant multispecies biofilms found in infected wounds, such as P. aeruginosa with Staphylococcus aureus, and additional elements such as mammalian cells, simulating fluids, and tissue explants in an attempt to better represent the physiological conditions found at an infection site. It is hoped this review will aid researchers in the field to make appropriate choices in their proposed studies with regards to in vitro models and methods.

show abstract

Section: Introductionmentioning

confidence: 99%

Current Status of In Vitro Models and Assays for Susceptibility Testing for Wound Biofilm Infections

Bahamondez-Canas

Heersema

2019

Biomedicines

View full text Add to dashboard Cite

show abstract

“…Pseudomonasa eruginosa infections occur in the respiratory tract [4,5], eyes [6], ears, skin wounds [7], bloodstream [1], or surgical site infections [8]. Pseudomonas aeruginosa can colonize human intestines and skin, and it can take advantage of any host's immunodeficiency to produce acute or chronic systemic infections [4,9]. Moreover, it is argued that P. aeruginosa infections are acquired from the bacterial population that colonizes the proximal environment of the host [10].…”

Section: Introductionmentioning

confidence: 99%

Pseudomonas aeruginosa transition from environmental generalist to human pathogen

Vasco¹,

Trueba²

2021

Av. Cienc. Ing. (Quito)

View full text Add to dashboard Cite

Opportunistic bacteria Pseudomonas aeruginosa is one of the major concerns as an etiological agent of nosocomial infections in humans. Many virulence factors used to colonize the human body are the same as those used by P. aeruginosa to thrive in the environment such as membrane transport, biofilm formation, oxidation/reduction reaction, among others. P. aeruginosa origin is mainly from the environment, the adaptation to mammalian tissues may follow a source-sink evolution model; the environment is the source of many lineages, some of them capable of adaptation to the human body. Some lineages may adapt to humans and go through reductive evolution in which some genes are lost. The understanding of this process may be critical to implement better methods to control outbreaks in hospitals.

show abstract

Pseudomonas aeruginosa and Bronchiectasis

Cited by 2 publications

References 154 publications

Current Status of In Vitro Models and Assays for Susceptibility Testing for Wound Biofilm Infections

Current Status of In Vitro Models and Assays for Susceptibility Testing for Wound Biofilm Infections

Pseudomonas aeruginosa transition from environmental generalist to human pathogen

Contact Info

Product

Resources

About