Pseudomonas aeruginosa

Pier, Gerald B.; Ramphal, Reuben

doi:10.1016/b978-0-443-06839-3.00219-8

Cited by 70 publications

(92 citation statements)

References 274 publications

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“…It also harbours in damaged bronchi of bronchiectasis patients leading to acute exacerbations. 4 Among the β-lactam antibiotics tested, carbapenems and piperacillin-tazobactam showed least resistance rates. These antibiotics have broader spectrum of activity than most β-lactam antibiotics, therefore were most effective against treating P. aeruginosa infections.…”

Section: Discussionmentioning

confidence: 99%

“…It not only limits therapeutic options but also affects clinical outcome by increasing morbidity and mortality. 4 Therefore, a study was conducted to determine the current antibiotic sensitivity and resistance rates which would help in laying down current recommendations for empirical antibiotic regimens for treating P. aeruginosa infections and also to minimize progression of MDR.…”

mentioning

confidence: 99%

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A prospective study to analyse antibiotic susceptibility pattern of Pseudomonas aeruginosa in a tertiary care hospital

Ameen¹,

Bairy

Imran

et al. 2016

Int J Basic Clin Pharmacol

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

A prospective study to analyse antibiotic susceptibility pattern of Pseudomonas aeruginosa in a tertiary care hospital

Ameen¹,

Bairy

Imran

et al. 2016

Int J Basic Clin Pharmacol

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“…P. aeruginosa stands out as a unique and threating organism as it is capable of causing severe invasive disease and of evading immune defenses causing persisting infections that are nearly impossible to eradicate (Pier & Ramphal, 2005). The subsequent tissue damage, invasion, and dissemination of P. aeruginosa are likely attributed to the many virulence factors it produces.…”

Section: Pathogenesis and Major Virulence Factorsmentioning

confidence: 99%

“…The main distinguishing feature of P. aeruginosa sepsis is the presence of ecthyma gangrenous, and these infarcted skin lesions occur only in markedly neutropenic patients (Pier & Ramphal, 2005). When P. aeruginosa disseminates from a site of local infection, it gains access to the bloodstream by breaking down epithelial and endothelial tissue barriers (Kurahashi et al, 1999).…”

Section: Bacteremiamentioning

confidence: 99%

Pseudomonas aeruginosa – Pathogenesis and Pathogenic Mechanisms

Alhazmi

2015

IJB

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Pseudomonas aeruginosa is a common bacterium, Gram-negative opportunistic pathogen capable of infecting humans with compromised natural defenses and causing severe pulmonary disease. It is one of the leading pathogen associated with nosocomial infections. It has a vast arsenal of pathogenicity factors that are used to interfere with host defenses. Pathogenesis in P. aeruginosa facilitates adhesion, modulate or disrupt host cell pathways, and target the extracellular matrix. The propensity of P. aeruginosa to form biofilms further protects it from antibiotics and the host immune system. P. aeruginosa is intrinsically resistant to a large number of antibiotics and can be acquired resistance to many others, making treatment difficult. P. aeruginosa provokes a potent inflammatory response during the infectious process. The majority of mortalities in immunocompromised patients; cystic fibrosis, can be attributed to the progressive decline of lung function resulting from chronic infection by pathogens such as P. aeruginosa. Antibiotic treatment of chronic P. aeruginosa infections may temporarily suppress symptoms; however, they do not eradicate the pathogen. Lung diseases caused by P. aeruginosa are a leading cause of death in immunocompromised individuals as well as in children. Although immunocytes recruitment is critical to augment the host defense, excessive neutrophil accumulation results in life-threatening diseases, such as acute lung injury, as well as acute respiratory distress syndrome. Several virulence factors have been studied for their roles as potential vaccine candidate, although there is currently no clinically accepted vaccine. Understanding host-pathogen interaction is critical for the development of effective therapeutic strategies to control the damage in the lung.

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“…The majority of hospitalized patients have an underlying medical condition or a risk factor for P. aeruginosa infection. The typical patient presenting with nosocomial P. aeruginosa infection is mechanically ventilated, has slowly progressive lung infiltrates, and has been colonized with P. aeruginosa for days (2). Although rare, there have been some reports of community-acquired P. aeruginosa pneumonia in previously healthy individuals (3)(4)(5)(6), for example, among individuals who have inhaled contaminated hot tub steam (5,6), and P. aeruginosa community-acquired pneumonia (CAP) presents as a rapidly progressive, sometimes fatal disease (3)(4)(5)(6).…”

Section: Introductionmentioning

confidence: 99%

Successful Treatment of Fulminant Community-Acquired <i>Pseudomonas aeruginosa</i> Necrotizing Pneumonia in a Previously Healthy Young Man

et al. 2012

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This report presents a case of fulminant community-acquired Pseudomonas aeruginosa necrotizing pneumonia in a previously healthy young man, including an analysis of the virulence of the P. aeruginosa isolated from the patient. The patient was successfully treated with intensive care and antibiotic treatment. This study analyzed the pathogenicity of the isolated strain both in vivo (using a mouse pneumonia model) and in vitro (using biofilm production), but could not explain how an otherwise healthy young man developed such severe community-acquired P. aeruginosa pneumonia. Although rare in community-acquired pneumonia, P. aeruginosa infection should be considered in patients with severe rapidly progressive pneumonia.

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Pseudomonas aeruginosa

Cited by 70 publications

References 274 publications

A prospective study to analyse antibiotic susceptibility pattern of Pseudomonas aeruginosa in a tertiary care hospital

A prospective study to analyse antibiotic susceptibility pattern of Pseudomonas aeruginosa in a tertiary care hospital

Pseudomonas aeruginosa – Pathogenesis and Pathogenic Mechanisms

Successful Treatment of Fulminant Community-Acquired <i>Pseudomonas aeruginosa</i> Necrotizing Pneumonia in a Previously Healthy Young Man

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