Pseudomonal airway colonisation: risk factor for bronchiolitis obliterans syndrome after lung transplantation?

Vos, Robin; Vanaudenaerde, Bart M.; Geudens, Nele; Dupont, L J; Raemdonck, Dirk Van; Verleden, Geert M.

doi:10.1183/09031936.00128607

Cited by 153 publications

(152 citation statements)

References 58 publications

(62 reference statements)

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“…Other factors from the environment associated with lung transplantation can also play a role in EMT of BO patients. Bacterial infection with Pseudomonas aeruginosa has been shown to significantly increase inflammation in lung transplant recipients [167]. BORTHWICK et al [168] have shown that bacteria are able to induce EMT in the presence of TGF-b.…”

Section: Emt and Bo Following Lung Transplantationmentioning

confidence: 99%

Tissue remodelling in chronic bronchial diseases: from the epithelial to mesenchymal phenotype

Pain

Bermúdez

Lacoste

et al. 2014

European Respiratory Review

169

128

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Airway remodelling is a critical feature of chronic bronchial diseases, characterised by aberrant repair of the epithelium and accumulation of fibroblasts, which contribute to extracellular matrix (ECM) deposition resulting in fixed bronchial obstruction. Recently, epithelial-mesenchymal transition (EMT) has been identified as a new source of fibroblasts that could contribute to the remodelling of the airways. This phenomenon consists of the loss of the epithelial phenotype by bronchial epithelial cells and the acquisition of a mesenchymal phenotype. These cells are then able to migrate and secrete ECM molecules. Herein, we review the different types of EMT. We will then focus on the signalling pathways that are involved, such as transforming growth factor-b and Wnt, as well as the more recently described Sonic Hedgehog pathway. Finally, we will highlight the implication of EMT in airway remodelling in specific chronic bronchial pathologies, such as asthma, chronic obstructive pulmonary disease and bronchiolitis obliterans following lung transplantation. Despite the limitations of in vitro models, future studies of EMT in vivo are warranted to shed new light on the pathomechanisms of bronchial obstruction. @ERSpublications Epithelial-mesenchymal transition in chronic bronchial remodelling diseases

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Section: Emt and Bo Following Lung Transplantationmentioning

confidence: 99%

Tissue remodelling in chronic bronchial diseases: from the epithelial to mesenchymal phenotype

Pain

Bermúdez

Lacoste

et al. 2014

European Respiratory Review

169

128

View full text Add to dashboard Cite

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“…Secondly, and perhaps more importantly, these epithelial abnormalities may increase the risk of allograft colonisation by pathogenic organisms. Indeed, bacteria such as Pseudomonas have been shown to adhere preferentially to injured, disrupted and regenerating areas of airway epithelium [30] and colonise the allograft in both CF [2,31,32] and non-CF [31,32] lung transplant recipients. A growing body of evidence points towards the potential role of allograft colonisation with microbes such as Pseudomonas [2,31,32] and Aspergillus [5] in the development of BOS.…”

Section: Discussionmentioning

confidence: 99%

Persistent disruption of ciliated epithelium following paediatric lung transplantation

et al. 2012

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It is unclear whether ciliary function following lung transplantation is normal or not. Our aim was to study the ciliary function and ultrastructure of epithelium above and below the airway anastomosis and the peripheral airway of children following lung transplantation.We studied the ciliary beat frequency (CBF) and beat pattern, using high speed digital video imaging and ultrastructure by transmission electron microscopy, of bronchial epithelium from above and below the airway anastomosis and the peripheral airway of 10 cystic fibrosis (CF) and 10 non-suppurative lung disease (NSLD) paediatric lung transplant recipients.Compared to epithelium below the anastomosis, the epithelium above the anastomosis in the CF group showed reduced CBF (median (interquartile range): 10.5 (9.0-11.4) Hz versus 7.4 (6.4-9.2) Hz; p,0.01) and increased dyskinesia (median (IQR): 16.5 (12.9-28.2)% versus 42.2 (32.6-56.4)%; p,0.01). In both CF and NSLD groups, compared with epithelium above the anastomosis, the epithelium below the anastomosis showed marked ultrastructural abnormalities (median duration post-transplant 7-12 months).Ciliary dysfunction is a feature of native airway epithelium in paediatric CF lung transplant recipients. The epithelium below the airway anastomosis shows profound ultrastructural abnormalities in both CF and NSLD lung transplant recipients, many months after transplantation.

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“…The role of lung allograft colonization by P aeruginosa as a risk factor for the development of BOS has not been fully determined (11,165).…”

Section: Bacterial Respiratory Tract Infectionmentioning

confidence: 99%

The Impact of Infection on Chronic Allograft Dysfunction and Allograft Survival After Solid Organ Transplantation

Martín-Gandul

Mueller

Pascual

et al. 2015

American Journal of Transplantation

130

103

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Infectious diseases after solid organ transplantation (SOT) are a significant cause of morbidity and reduced allograft and patient survival; however, the influence of infection on the development of chronic allograft dysfunction has not been completely delineated. Some viral infections appear to affect allograft function by both inducing direct tissue damage and immunologically related injury, including acute rejection. In particular, this has been observed for cytomegalovirus (CMV) infection in all SOT recipients and for BK virus infection in kidney transplant recipients, for community-acquired respiratory viruses in lung transplant recipients, and for hepatitis C virus in liver transplant recipients. The impact of bacterial and fungal infections is less clear, but bacterial urinary tract infections and respiratory tract colonization by Pseudomonas aeruginosa and Aspergillus spp appear to be correlated with higher rates of chronic allograft dysfunction in kidney and lung transplant recipients, respectively. Evidence supports the beneficial effects of the use of antiviral prophylaxis for CMV in improving allograft function and survival in SOT recipients. Nevertheless, there is still a need for prospective interventional trials assessing the potential effects of preventive and therapeutic strategies against bacterial and fungal infection for reducing or delaying the development of chronic allograft dysfunction.

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Pseudomonal airway colonisation: risk factor for bronchiolitis obliterans syndrome after lung transplantation?

Cited by 153 publications

References 58 publications

Tissue remodelling in chronic bronchial diseases: from the epithelial to mesenchymal phenotype

Tissue remodelling in chronic bronchial diseases: from the epithelial to mesenchymal phenotype

Persistent disruption of ciliated epithelium following paediatric lung transplantation

The Impact of Infection on Chronic Allograft Dysfunction and Allograft Survival After Solid Organ Transplantation

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