Pseudomonadota in the oral cavity: a glimpse into the environment-human nexus

Abstract

The phylum Pseudomonadota is amongst the most represented in the environment, with a comparatively lower prevalence in the human oral cavity. The ubiquity of Pseudomonadota and the fact that the oral cavity is the most likely entry portal of bacteria from external sources underlie the need to better understand its occurrence in the interface environment-humans. Yet, the relevance oral Pseudomonadota is largely underexplored in the scientific literature, a gap that this review aims at addressing by making, for the first time, an overview of the diversity and ecology of Pseudomonadota in the oral cavity. The screening of scientific literature and human microbiome databases unveiled 1328 reports of Pseudomonadota in the oral cavity. Most of these belonged to the classes Beta- and Gammaproteobacteria, mainly to the families Neisseriaceae, Campylobacteriaceae, and Pasteurelaceae. Others also regularly reported include genera such as Enterobacter, Klebsiella, Acinetobacter, Escherichia, Burkholderia, or Citrobacter, whose members have high potential to acquire virulence and antibiotic resistance genes. This review provides evidence that clinically relevant environmental Pseudomonadota may colonize humans via oral cavity. The need for further investigation about Pseudomonadota at the environment-oral cavity interface and their role as vectors potentially involved in virulence and antibiotic resistance transmission is demonstrated. Key points • Neisseriaceae, Campylobacteriaceae, and Pasteurelaceae are part of the core oral microbiome • Enterobacteriaceae, Acinetobacter, or Burkholderia are frequent in the oral microbiome • Gut dysbiosis may be associated with colonization by ubiquitous oral Pseudomonadota Graphical abstract

Effective disinfecting of negative pressure pipelines of DCUs reduces the risk of cross infection in dental care

“…Pseudomonads are ubiquitous in pipelines, metals, and water. However, they can also be found in oral cavities, as clarified in the study [ 22 ].…”

Longitudinal analysis of microbiome composition in Ghanaians living with HIV-1

“…Furthermore, some upregulated pathways are possessed by groups of bacteria known as pathogenic and opportunistic. Catechol degradation II, L-histidine degradation II, and nicotinate degradation I are pathways possessed by the phylum Pseudomonadota , whose members include the families Neisseriaceae, Campylobacteriaceae, Enterobacteriaceae, Klebsiella, Escherichia, Burkholderiaceae, and Pseudomonadaceae ( Leão et al, 2023 ).…”

“…Comparison between baseline_control and follow-up_case to baseline_case reveals that samples from baseline_case likely have enrichment of pathways related to bacteria, some even exclusive to the phylum Pseudomonadota. The members of this phylum are known to be pathogens of the respiratory tract ( Achromobacter, Klebsiella, Pseudomonas, Sternotrophomonas ), gastrointestinal tract ( Aeromonas, Campylobacter, Escherichia, Helicobacter ), and blood ( Brevundimonas, Neisseria, Serratia, Stenotrophomonas ), among other conditions ( Citrobacter, Enterobacter, Haemophilus, Proteus ) ( Leão et al, 2023 ). This implies that the activity of pathogenic bacteria was high in the baseline case.…”

Impacts of sulfamethoxazole stress on vegetable growth and rhizosphere bacteria and the corresponding mitigation mechanism

“…At the phylum level, Pseudomonadota was identified as the dominant phylum for all samples, followed by Actinomycetota . Pseudomonadota , better known as proteobacteria, is the most prevalent bacterial phylum in the environment ( Leão et al, 2023 ; Selmani et al, 2023 ). This phylum includes many rhizobacteria associated with plant growth promoting activities, including nitrogen fixation, phosphorus uptake, and antifungal effect ( Ramakrishna et al, 2019 ; Gómez-Godínez et al, 2023 ).…”