Pseudomelanosis duodeni: a clinicopathologic entity

Yamase, Harold; Norris, Mary; Gillies, Concettina

doi:10.1016/s0016-5107(85)72001-9

Cited by 24 publications

(14 citation statements)

References 5 publications

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“…1 The classic endoscopic appearance of pseudomelanosis is black or brown peppered pigmentation of the gastric, duodenal, and jejunal mucosa. 13,16 The exact etiology and pathogenesis for this aberrant pigment deposition is still unclear. 2 The black, brown, or gray pigment of pseudomelanosis was originally hypothesized to be composed of melanin.…”

Section: Discussionmentioning

confidence: 99%

Pseudomelanosis of Stomach, Duodenum, and Jejunum

Rustagi

Mansoor²,

Gibson³

et al. 2015

Journal of Clinical Gastroenterology

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Pseudomelanosis is a rare finding during upper gastrointestinal endoscopy, and is most commonly seen in the duodenum. Involvement of other organs in the upper gastrointestinal tract is extremely rare, with only 1 reported case involving the stomach, duodenum, and jejunum. We present a case of a 60-year-old woman with mild anemia and hematemesis, who was found to have characteristic speckled pattern of gray-black pigmentation on endoscopic examination. To the best of our knowledge, this is the second reported case of pseudomelanosis involving the stomach, duodenum, and jejunum.

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Section: Discussionmentioning

confidence: 99%

Pseudomelanosis of Stomach, Duodenum, and Jejunum

Rustagi

Mansoor²,

Gibson³

et al. 2015

Journal of Clinical Gastroenterology

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“…The pigment accumulation contains iron, sulfur, or melanin‐like substances, such as hemosiderin, lipomelanin, and lipofuscin, and the pigment color represents various degrees of auto‐oxidation of ferrous sulfide [7,8]. The exact pathogenesis remains unclear.…”

Section: Discussionmentioning

confidence: 99%

“…The biopsy specimens were positive for Perls' Prussian blue stain but not reactive for Masson–Fontana stain. Although Perls' Prussian blue stain is commonly used to reveal iron in tissues, a false‐negative reaction is possible if an iron oxide compound is present rather than iron sulfide [8].…”

Section: Discussionmentioning

confidence: 99%

Pseudomelanosis duodeni in a female adult with chronic renal failure

Sun

Tsay

Lai

et al. 2014

Adv in Digestive Medicine

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Pseudomelanosis duodeni is a rare endoscopic finding that manifests as dark speckled spots in the duodenum. It is considered a benign condition and is associated with certain diseases and the use of certain medications. This study reports a case of a 74-yearold woman, with end-stage renal disease under maintenance hemodialysis, hypertension under regular medical control, iron deficiency anemia under oral iron supplement, and progressive anemia with suspicious occult gastrointestinal bleeding. Upper gastrointestinal endoscopy revealed multiple tiny brownish-black pigmentation throughout the proximal second portion of the duodenum. The histopathological examination showed pigment-laden macrophages with positive iron stain and negative melanin stain in the lamina propria of the mucosal villi.

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“…3,4 Contrary to association of melanosis coli with anthraquinone laxatives, PMD has no such reported links. PMD has been associated with several medical conditions, including end-stage renal disease, hypertension, chronic heart failure, diabetes mellitus, gastrointestinal hemorrhage, and medications including anti-hypertensives and iron supplementation.…”

mentioning

confidence: 99%

“…3 While melanosis coli is secondary to accumulation of lipofuscin in the macrophages of the lamina propria, the predominant pigments deposited in PMD are iron sulfide and hemosiderin ( Figure 3). 3,4 Contrary to association of melanosis coli with anthraquinone laxatives, PMD has no such reported links. PMD has been associated with several medical conditions, including end-stage renal disease, hypertension, chronic heart failure, diabetes mellitus, gastrointestinal hemorrhage, and medications including anti-hypertensives and iron supplementation.…”

mentioning

confidence: 99%

Pseudomelanosis Duodeni

&NA;

1988

Journal of Clinical Gastroenterology

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A 55-year-old male with history of coronary artery disease, chronic kidney disease stage 4, diabetes mellitus, uncontrolled hypertension (on multiple antihypertensive medications), and iron deficiency anemia was referred for esophagogastroduodenoscopy (EGD) for evaluation of intractable nausea and vomiting. EGD showed black speckled pigmentation of the duodenal mucosa ( Figure 1). Duodenal biopsy revealed hemosiderin deposition in the lamina propria of the duodenum, consistent with a diagnosis of pseudomelanosis duodeni (PMD; Figure 2). PMD is the rare endoscopic appearance of black speckled pigmentation of the duodenum commonly seen in females in the sixth and seventh decades of life.1,2 The most common extracolonic site for pseudomelanosis of the gastrointestinal tract is the duodenum.3 While melanosis coli is secondary to accumulation of lipofuscin in the macrophages of the lamina propria, the predominant pigments deposited in PMD are iron sulfide and hemosiderin (Figure 3). 3,4 Contrary to association of melanosis coli with anthraquinone laxatives, PMD has no such reported links. PMD has been associated with several medical conditions, including end-stage renal disease, hypertension, chronic heart failure, diabetes mellitus, gastrointestinal hemorrhage, and medications including anti-hypertensives and iron supplementation.

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Pseudomelanosis duodeni: a clinicopathologic entity

Cited by 24 publications

References 5 publications

Pseudomelanosis of Stomach, Duodenum, and Jejunum

Pseudomelanosis of Stomach, Duodenum, and Jejunum

Pseudomelanosis duodeni in a female adult with chronic renal failure

Pseudomelanosis Duodeni

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